Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Harry H Matundan"'
Autor:
Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, Homayon Ghiasi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner. Since TH17 cells have been implicated in CNS pathology, in the present study, we
Externí odkaz:
https://doaj.org/article/6dec023a402c4ed3b35b88e5581101fd
Publikováno v:
mSphere, Vol 7, Iss 5 (2022)
ABSTRACT Over the past 70 years, multiple approaches to develop a prophylactic or therapeutic vaccine to control herpes simplex virus (HSV) infection have failed to protect against primary infection, reactivation, or reinfection. In contrast to many
Externí odkaz:
https://doaj.org/article/8ec1f841af3447e8ad8510eb9350fae4
Autor:
Ujjaldeep Jaggi, Harry H Matundan, Jack Yu, Satoshi Hirose, Mathias Mueller, Floyd L Wormley, Homayon Ghiasi
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009999 (2021)
Ocular HSV-1 infection is a major cause of eye disease and innate and adaptive immunity both play a role in protection and pathology associated with ocular infection. Previously we have shown that M1-type macrophages are the major and earliest infilt
Externí odkaz:
https://doaj.org/article/fc977b80a51a4b22958b32729e59586c
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT We previously reported that herpes simplex virus 1 (HSV-1) ICP22 binds to CD80 and suppresses CD80 expression in vitro and in vivo. Similar to ICP22, the cellular costimulatory molecules CD28, CTLA4, and PD-L1 also bind to CD80. In this stud
Externí odkaz:
https://doaj.org/article/9776df8d282c476986c1363b6893cbc8
Autor:
Ujjaldeep Jaggi, Mingjie Yang, Harry H Matundan, Satoshi Hirose, Prediman K Shah, Behrooz G Sharifi, Homayon Ghiasi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008971 (2020)
After HSV-1 infection, macrophages infiltrate early into the cornea, where they play an important role in HSV-1 infection. Macrophages are divided into M1 or M2 groups based on their activation. M1 macrophages are pro-inflammatory, while M2 macrophag
Externí odkaz:
https://doaj.org/article/c45410c76a094182a425b9337d97f4e9
Publikováno v:
J Virol
Macrophages are one of the first innate immune infiltrates in the cornea of mice following ocular infection with herpes simplex virus 1 (HSV-1). Using gamma interferon (IFN-γ) and interleukin-4 (IL-4) injections to polarize macrophages into M1 and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41635af8b4514af67a2e8186fafeb571
https://europepmc.org/articles/PMC9645210/
https://europepmc.org/articles/PMC9645210/
Autor:
Kati Tormanen, Harry H. Matundan, Shaohui Wang, Ujjaldeep Jaggi, Kevin R. Mott, Homayon Ghiasi
Publikováno v:
J Virol
The HSV-1 latency-associated transcript (LAT) locus contains two small noncoding RNA (sncRNA) sequences (sncRNA1 and sncRNA2) that are not microRNAs (miRNAs). We recently reported that sncRNA1 is more important for in vitro activation of the herpesvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7e50d885362f184420be61e14bf83f
https://europepmc.org/articles/PMC9006899/
https://europepmc.org/articles/PMC9006899/
Herpes Simplex Virus 1 Small Noncoding RNAs 1 and 2 Activate the Herpesvirus Entry Mediator Promoter
Publikováno v:
J Virol
Herpes simplex virus 1 (HSV-1) latency-associated transcript (LAT) plays a significant role in efficient establishment of latency and reactivation. LAT has antiapoptotic activity and downregulates expression of components of the type I interferon pat
Autor:
Mathias Mueller, Satoshi Hirose, Jack C. Yu, Ujjaldeep Jaggi, Harry H. Matundan, Homayon Ghiasi, Floyd L. Wormley
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 10, p e1009999 (2021)
PLoS Pathogens, Vol 17, Iss 10, p e1009999 (2021)
Ocular HSV-1 infection is a major cause of eye disease and innate and adaptive immunity both play a role in protection and pathology associated with ocular infection. Previously we have shown that M1-type macrophages are the major and earliest infilt
Publikováno v:
Journal of Virology. 95
Previously, we reported that herpes simplex virus type 1 (HSV-1) ICP22 binds to the CD80 promoter and suppresses its expression in vitro and in vivo. To better understand the impact of ICP22 binding to CD80 on HSV-1 infectivity and pathogenicity, we