Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Harry G. Parkes"'
Autor:
Anne Christine Lf Wong Te Fong, James Mui, Roland A. Fleck, Lesley-Ann Martin, Gigin Lin, Louise Howell, Elham Shamsaei, Yuen-Li Chung, Gabriela Andrejeva, Florence I. Raynaud, Joanna Nikitorowicz-Buniak, Sharon Gowan, Yasmin Asad, Harry G. Parkes, Melanie Valenti, Vladimir Kirkin, Gema Vizcay-Barrena, Martin O. Leach
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Macroautophagy/autophagy can enable cancer cells to withstand cellular stress and maintain bioenergetic homeostasis by sequestering cellular components into newly formed double-membrane vesicles destined for lysosomal degradation, potentially affecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1b82f6d738466d1f0a8fc6e6b716b5
http://europepmc.org/articles/PMC7469489
http://europepmc.org/articles/PMC7469489
Autor:
Gigin Lin, Gabriela Andrejeva, Anne-Christine Wong Te Fong, Deborah K Hill, Matthew R Orton, Harry G Parkes, Dow-Mu Koh, Simon P Robinson, Martin O Leach, Thomas R Eykyn, Yuen-Li Chung
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92645 (2014)
Autophagy is a highly regulated, energy dependent cellular process where proteins, organelles and cytoplasm are sequestered in autophagosomes and digested to sustain cellular homeostasis. We hypothesized that during autophagy induced in cancer cells
Externí odkaz:
https://doaj.org/article/9175f8dc0853424ca4a36e28c152cc93
Autor:
E. Louise Thomas, James R.C. Parkinson, Gary Frost, Leigh Brody, Meliz Sahuri-Arisoylu, Harry G Parkes, Nabil Hajji, Jimmy D. Bell, Po-Wah So, Andrew D. Miller
Publikováno v:
International Journal of Nanomedicine
Leigh P Brody,1,* Meliz Sahuri-Arisoylu,1,* James R Parkinson,1 Harry G Parkes,2 Po Wah So,3 Nabil Hajji,4 E Louise Thomas,1 Gary S Frost,5 Andrew D Miller,6,* Jimmy D Bell1,* 1Department of Life Sciences, Faculty of Science and Technology, Universit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e05ec8d7638a7d92ba5723ce632d674
https://www.dovepress.com/cationic-lipid-based-nanoparticles-mediate-functional-delivery-of-acet-peer-reviewed-article-IJN
https://www.dovepress.com/cationic-lipid-based-nanoparticles-mediate-functional-delivery-of-acet-peer-reviewed-article-IJN
Autor:
Thomas R. Eykyn, Gabriela Andrejeva, Gigin Lin, Helen Troy, M Jafar, Jessica K.R. Boult, Harry G. Parkes, Deborah K. Hill, Y-L Chung, Matthew R. Orton, Simon P. Robinson, John R. Griffiths, D-M. Koh, Ian Judson, Rafal Panek, Martin O. Leach, A-C L F W T Fong
Publikováno v:
British Journal of Cancer
Background: Dichloroacetate (DCA) has been found to have antitumour properties. Methods: We investigated the cellular and metabolic responses to DCA treatment and recovery in human colorectal (HT29, HCT116 WT and HCT116 Bax-ko), prostate carcinoma ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdac081801cd23cc58e34be5da13514e
https://doi.org/10.1038/bjc.2014.281
https://doi.org/10.1038/bjc.2014.281
Publikováno v:
Journal of Molecular and Cellular Cardiology. 32:853-858
NMR spectroscopy is an invaluable technique in metabolic investigations of isolated, perfused hearts. Most studies employ global perfusion methods together with an NMR coil that surrounds the heart and thus detects signals from its entirety. The pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1b153c1dfa44b0d7b97bf1fe79d637
https://doi.org/10.1006/jmcc.2000.1112
https://doi.org/10.1006/jmcc.2000.1112
Autor:
Markella Koniordou, Martin O. Leach, Slawomir Wantuch, Thomas R. Eykyn, Paul D. Smith, Mounia Beloueche-Babari, Vaitha Arunan, Harry G. Parkes
Publikováno v:
Molecular Cancer Therapeutics. 14:C113-C113
Background: Monocarboxylate transporters (MCTs) are key modulators of lactate homeostasis and represent promising metabolic targets for molecular cancer therapeutics. The MCT1 inhibitor AZD3965 is now in clinical trial and understanding the impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a96466a3a1942cc646ec611e87999d
https://doi.org/10.1158/1535-7163.targ-15-c113
https://doi.org/10.1158/1535-7163.targ-15-c113
Autor:
James Mui, Yuen-Li Chung, Martin O. Leach, Gema Vizcay-Barrena, Gigin Lin, Anne-Christine Wong Te Fong, Roland A. Fleck, Gabriela Andrejeva, Harry G. Parkes
Publikováno v:
Cancer Research. 75:2897-2897
Autophagy is a cellular stress survival mechanism in which newly formed double-membrane vesicles target parts of the cytosol and organelles for lysosomal degradation to maintain cellular energy production. The source of the autophagosome membrane in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3eeed2ba274deebad5e4c07135edc3
https://doi.org/10.1158/1538-7445.am2015-2897
https://doi.org/10.1158/1538-7445.am2015-2897
Publikováno v:
Journal of the Neurological Sciences. 168:1-12
In the C57BL/Wld s (Wld) mouse strain, both PNS and CNS axonal disintegration during Wallerian degeneration is dramatically slowed, with isolated axons being able to conduct compound action potentials (CAPs) for several weeks post-transection. The ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52572c2de4e2aa352874802401c2175
https://doi.org/10.1016/s0022-510x(99)00161-6
https://doi.org/10.1016/s0022-510x(99)00161-6
Autor:
Lewis Spitz, Simon Eaton, Paisarn Vejchapipat, Harry G Parkes, Agostino Pierro, Koji Fukumoto
Publikováno v:
Nutrition (Burbank, Los Angeles County, Calif.). 18(4)
Objectives: The liver plays a central role during endotoxemia. We investigated the biochemical changes that occur in neonatal liver during early stages of endotoxemia. Methods: Twenty neonatal rats (10 to 15 d; n = 10/group) were studied. Endotoxemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adad5afd0d944286d05b0ae885b96c9
https://pubmed.ncbi.nlm.nih.gov/11934538
https://pubmed.ncbi.nlm.nih.gov/11934538
Autor:
Yuen-Li Chung, Thomas R. Eykyn, Anne-Christine Wong Te Fong, Deborah K. Hill, Gigin Lin, Matthew R. Orton, Dow-Mu Koh, Gabriela Andrejeva, Martin O. Leach, Simon P. Robinson, Harry G. Parkes
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92645 (2014)
PLoS ONE
PLoS ONE
Autophagy is a highly regulated, energy dependent cellular process where proteins, organelles and cytoplasm are sequestered in autophagosomes and digested to sustain cellular homeostasis. We hypothesized that during autophagy induced in cancer cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe735d78242a451af22825ebb98d18b
https://doi.org/10.1371/journal.pone.0092645
https://doi.org/10.1371/journal.pone.0092645