Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Harry G. Klip"'
1
Akademický článek
Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer
Autor: Tushar Tomar, Nicolette G. Alkema, Leroy Schreuder, Gert Jan Meersma, Tim de Meyer, Wim van Criekinge, Harry G. Klip, Heidi Fiegl, Els van Nieuwenhuysen, Ignace Vergote, Martin Widschwendter, Ed Schuuring, Ate G. J. van der Zee, Steven de Jong, G. Bea A. Wisman
Publikováno v: BMC Medicine, Vol 15, Iss 1, Pp 1-16 (2017)
Abstract Background Despite an early response to platinum-based chemotherapy in advanced stage high-grade serous ovarian cancer (HGSOC), the majority of patients will relapse with drug-resistant disease. Aberrant epigenetic alterations like DNA methy
Externí odkaz: https://doaj.org/article/a06eb7d5a96d40b0ba2f31f1bb438006
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2
Akademický článek
Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways
Autor: Tushar Tomar, Steven de Jong, Nicolette G. Alkema, Rieks L. Hoekman, Gert Jan Meersma, Harry G. Klip, Ate GJ van der Zee, G. Bea A. Wisman
Publikováno v: Genome Medicine, Vol 8, Iss 1, Pp 1-15 (2016)
Abstract Background In high-grade serous ovarian cancer (HGSOC), intrinsic and/or acquired resistance against platinum-containing chemotherapy is a major obstacle for successful treatment. A low frequency of somatic mutations but frequent epigenetic
Externí odkaz: https://doaj.org/article/16fccca0c13749d5b29ece75b24e301f
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