Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Harry Ford"'
Autor:
Esther Manor, Livnat Zalah, Alexander Konson, Victor E. Marquez, Harry Ford, Riad Agbaria, Mahmoud Huleihel, David G. Johns
Publikováno v:
Antiviral Research. 55:63-75
N -Methanocarbathymidine (( N )-MCT), a thymidine analog incorporating a pseudosugar with a fixed Northern conformation, exhibits potent antiherpetic activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). This study contrasts the metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcb77acb18f1712b5ec2a7c9bfbd28a
https://doi.org/10.1016/s0166-3542(02)00010-4
https://doi.org/10.1016/s0166-3542(02)00010-4
Autor:
Harry Ford, R. Michael Blaese, David A. Cooney, Riad Agbaria, James A. Kelley, Zhang Hao, David G. Johns, Fabio Candotti
Publikováno v:
Biochemical and Biophysical Research Communications. 289:525-530
A method is described for the preparation of ganciclovir triphosphate (GCV-TP) using murine colon cancer cells (MC38) transduced with the herpes simplex virus-thymidine kinase (MC38/HSV-tk). Murine cells transduced with viral-tk contain required vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0279dcc51e606d25f2b75256318e8d45
https://doi.org/10.1006/bbrc.2001.6011
https://doi.org/10.1006/bbrc.2001.6011
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 25:285-297
High sensitivity (10(-7) to 10(-9) M) reversed-phase high-performance liquid chromatography (HPLC) analysis of adenine nucleosides and nucleotides, especially in a biological matrix, is difficult using only ultraviolet detection. Derivatization coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488a0df95f1daeaa483417a7bc02c37d
https://doi.org/10.1016/s0731-7085(00)00496-9
https://doi.org/10.1016/s0731-7085(00)00496-9
Autor:
James A. Kelley, Mark F. Kavlick, Fang Dai, Lauri Welles, Heping Zhang, Nancy Malinowski, Harry Ford, Jill Lietzau, Robert Yarchoan
Publikováno v:
Analytical Biochemistry. 288:52-61
A sensitive precolumn derivatization method has been developed to measure the 5'-triphosphate of 2'-beta-fluoro-2',3'-dideoxyadenosine (F-ddA, lodenosine), a new anti-HIV drug, in human lymphocytes by HPLC using fluorescence detection. Reaction of ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904e1fbc1e2a771507090755490dcc32
https://doi.org/10.1006/abio.2000.4862
https://doi.org/10.1006/abio.2000.4862
Autor:
Marc C. Nicklaus, Maqbool A. Siddiqui, Victor E. Marquez, Joseph J. Barchi, Fang Dai, Lan Mu, Harry Ford, Lynne Anderson
Publikováno v:
Biochemistry. 39:2581-2592
Several recent X-ray crystal structures of adenosine deaminase (ADA) in complex with various adenosine surrogates have illustrated the preferred mode of substrate binding for this enzyme. To define more specific structural details of substrate prefer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd20ebb791e775bdb25e94b284116ae9
https://doi.org/10.1021/bi992112c
https://doi.org/10.1021/bi992112c
Autor:
Victor E. Marquez, Marc C. Nicklaus, R. Alonso, Fang Dai, Clifford George, Maqbool A. Siddiqui, Harry Ford, Susana Hernandez, Russ Pamela L
Publikováno v:
Helvetica Chimica Acta. 82:2119-2129
Conformationally restricted carbocyclic nucleosides with either a northern(N)-type conformation, i.e., N-type 2′-deoxy-methanocarba-adenosine 8 ((N)MCdAdo), or a southern(S)-type conformation, i.e.S-type 2′-deoxy-methanocarba-adenosine 9, ((S)MCd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ef1d9f31aad8fdcf324dfa0296d7322
https://doi.org/10.1002/(sici)1522-2675(19991215)82:12<2119::aid-hlca2119>3.0.co
https://doi.org/10.1002/(sici)1522-2675(19991215)82:12<2119::aid-hlca2119>3.0.co
Publikováno v:
Tetrahedron. 55:2865-2874
4-(Carboxymethyl)phenylalanine ( 2 ) and its α,α-difluoro homologue 4-(carboxydifluoromethyl)phenylalanine ( 3 ) have been described as phosphotyrosyl mimetics. Herein we report the synthesis of N-Fmoc 4-( O -tert-butyl carboxymethyl)phenylalanine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1d3062716e29ae6bbbb072d55349b8f
https://doi.org/10.1016/s0040-4020(99)00076-9
https://doi.org/10.1016/s0040-4020(99)00076-9
Autor:
Janice R. Sufrin, Estela Alvarez, Canio J. Marasco, Victor E. Marquez, Xiaodong Cheng, Adam S. Brank, Margaret O'Gara, Harry Ford, Judith K. Christman, Amanda J. Goddard, Gholamreza Sheikhnejad
Publikováno v:
Journal of Molecular Biology. 285:2021-2034
A key step in the predicted mechanism of enzymatic transfer of methyl groups from S-adenosyl- l -methionine (AdoMet) to cytosine residues in DNA is the transient formation of a dihydrocytosine intermediate covalently linked to cysteine in the active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4829e75f565ddb91ce3ae3f0c2544cb5
https://doi.org/10.1006/jmbi.1998.2426
https://doi.org/10.1006/jmbi.1998.2426
Autor:
Clifford George, Joseph J. Barchi, Victor E. Marquez, Maqbool A. Siddiqui, Ron J. Feldman, Pamela Russ, Abdallah Ezzitouni, Hiroaki Mitsuya, Harry Ford
Publikováno v:
Nucleosides and Nucleotides. 17:1881-1884
Two conformationally locked carba-AZT nucleoside 5′-triphosphates built on a rigid bicyclo[3.1.0]hexane template showed exclusive Northern (2E) and Southern (3E) conformations, respectively. Inhibition of reverse transcriptase (RT) occurred selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a1ef6f36a165d7c20cf581b8feffc10
https://doi.org/10.1080/07328319808004726
https://doi.org/10.1080/07328319808004726