Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Harry E. Hynes"'
Autor:
Nicholas J. Robert, Gregory A. Parker, Harry E. Hynes, William A. Ferri, David M. Loesch, Lina Asmar, Vikki A. Canfield, Peter G. Ellis
Publikováno v:
Breast Cancer Research and Treatment. 77:115-123
This phase II multicenter trial evaluated the efficacy and toxicity of weekly paclitaxel, 5-fluorouracil, and leucovorin administered as first-line therapy for metastatic breast cancer.The study enrolled 155 women with pathologically confirmed and me
Autor:
Robert T. Dorr, James H. Doroshow, Muhammad Shurafa, Frederick R. Appelbaum, Kenneth J. Kopecky, Chatchada Karanes, Alan F. List, Marilyn L. Slovak, Cheryl L. Willman, David R. Head, Harry E. Hynes, Diane L. Persons
Publikováno v:
Blood. 98:3212-3220
Cyclosporine A (CsA) inhibits P-glycoprotein (Pgp)–mediated cellular export of anthracyclines at clinically achievable concentrations. This randomized controlled trial was performed to test the benefit of CsA addition to treatment with cytarabine a
Autor:
M. R. Grever, Kenneth J. Kopecky, Eric H. Kraut, David R. Head, Frederick R. Appelbaum, Alan E. Lichtin, Harry E. Hynes, Wolfram E. Samlowski, Chatchada Karanes, Richard H. Vial, Sucha Nand
Publikováno v:
Leukemia Research. 23:787-794
The aim of this study is to determine whether the addition of mitoxantrone to high dose cytarabine improves the outcome of treatment in patients with relapsed or refractory acute myeloid leukemia (AML). One hundred and sixty-two eligible patients, 14
Autor:
Joseph A. Roscoe, Jeffrey J. Kirshner, Gary R. Morrow, M.P.H. Jane T. Hickok M.D., Harry E. Hynes, Bo Yang, Robert M. Stern, Richard J. Rosenbluth, Patrick J. Flynn
Publikováno v:
Cancer. 86:64-71
BACKGROUND Although 5-HT3 receptor antagonists are clinically more effective in controlling emesis, particularly that caused by high dose cisplatin, than previously available agents, they appear to be less effective against nausea. This report focuse
Autor:
Stanley P. Balcerzak, David R. Head, Harry E. Hynes, Cheryl L. Willman, Catherine P. Leith, Frederick R. Appelbaum, Kenneth J. Kopecky, John E. Godwin
Publikováno v:
Blood. 91:3607-3615
Older age is a poor prognosis factor in acute myeloid leukemia (AML). This double-blind trial was designed to test the hypothesis that granulocyte colony-stimulating factor (G-CSF) used as supportive care could improve the treatment of elderly AML pa
Autor:
Joseph A. Roscoe, Gary R. Morrow, Thomas G. Burish, Harry E. Hynes, Patrick J. Flynn, H I Pierce
Publikováno v:
Supportive Care in Cancer. 6:46-50
Chemotherapy-related nausea and vomiting (NV) in 300 consecutive patients treated in community practices prior to the availability of 5-HT3 antiemetics (9/87 to 1/91) were compared with NV in a second sample of 300 patients treated after their commer
Autor:
Harry E. Hynes, Stanley P. Balcerzak, Kenneth J. Kopecky, Frank L. Meyskens, Frederick R. Appelbaum, Wolfram E. Samlowski
Publikováno v:
Leukemia Research. 19:605-612
A national cooperative group trial was conducted in 153 patients with chronic myelogenous leukemia (CML) in chronic phase treated with oral pulse busulfan to determine if oral vitamin A can increase the time to blast crisis and enhance survival of pa
Autor:
Harry E. Hynes, Conrad H. Gumbart, Robert W. Veith, Donna H. Ryan, Richard H. Vial, David R. Head, Kenneth J. Kopecky, David A. Lipschitz, Michael R. Grever, Stephen M. Shiaer
Publikováno v:
American Journal of Clinical Oncology. 15:69-75
Fourteen participating centers registered 33 patients on a Southwest Oncology Group Study of adults with acute non-lymphocytic leukemia (ANLL). Induction consisted of cytosine arabinoside 70 mg/m2 days 1-7 by continuous intravenous (i.v.) infusion, V
Autor:
Georgiana K. Ellis, Charles A. Coltman, Robert B. Livingston, Saul E. Rivkin, Susan Schulman, Harry E. Hynes, Stephanie Green
Publikováno v:
Cancer. 68:934-939
Twenty-seven women with metastatic breast cancer were treated with doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH) every other week, alternating with 5-fluorouracil (5FU) and high-dose calcium leucovorin, for a 12-week induction regimen, f
Autor:
Patrick J. Flynn, Tarit K. Banerjee, Richard F. Raubertas, Harry E. Hynes, Jeffrey J. Kirshner, David K. King, Joseph A. Roscoe, Gary R. Morrow, Jane T. Hickok, Paul L.R. Andrews
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 21(24)
Purpose: Fatigue and depression typically occur together in cancer patients, suggesting a common etiology, perhaps based on serotonin. This randomized clinical trial tested whether paroxetine, a selective serotonin reuptake inhibitor antidepressant k