Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Harry E. Gwirtsman"'
Autor:
Eric M. Reiman, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz, Matthew J. Huentelman, Thomas G. Beach, Richard J. Caselli, Yinghua Chen, Yi Su, Amanda J. Myers, John Hardy, Jean Paul Vonsattel, Steven G. Younkin, David A. Bennett, Philip L. De Jager, Eric B. Larson, Paul K. Crane, C. Dirk Keene, M. Ilyas Kamboh, Julia K. Kofler, Linda Duque, John R. Gilbert, Harry E. Gwirtsman, Joseph D. Buxbaum, Dennis W. Dickson, Matthew P. Frosch, Bernardino F. Ghetti, Kathryn L. Lunetta, Li-San Wang, Bradley T. Hyman, Walter A. Kukull, Tatiana Foroud, Jonathan L. Haines, Richard P. Mayeux, Margaret A. Pericak-Vance, Julie A. Schneider, John Q. Trojanowski, Lindsay A. Farrer, Gerard D. Schellenberg, Gary W. Beecham, Thomas J. Montine, Gyungah R. Jun, The Alzheimer’s Disease Genetics Consortium
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE
Externí odkaz:
https://doaj.org/article/8db8cb1befa541b785dc4ef289037901
Autor:
Hakmook Kang, Suzanne L. Baker, Harry E. Gwirtsman, Paul A. Newhouse, Sepideh Shokouhi, Alzheimer’s Disease Neuroimaging Initiative, Kimberly Albert, Alexander C. Conley
Publikováno v:
Neurobiol Aging
We evaluated the associations of subjective (self-reported everyday cognition [ECog]) and objective cognitive measures with regional amyloid-β (Aβ) and tau accumulation in 86 clinically normal elderly subjects from the Alzheimer's Disease Neuroimag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f7c47f9d21504d7487c5b51439f7d7
https://doi.org/10.1016/j.neurobiolaging.2019.05.011
https://doi.org/10.1016/j.neurobiolaging.2019.05.011
Autor:
Adam C Naj, Gary W Beecham, Eden R Martin, Paul J Gallins, Eric H Powell, Ioanna Konidari, Patrice L Whitehead, Guiqing Cai, Vahram Haroutunian, William K Scott, Jeffery M Vance, Michael A Slifer, Harry E Gwirtsman, John R Gilbert, Jonathan L Haines, Joseph D Buxbaum, Margaret A Pericak-Vance
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001130 (2010)
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant ass
Externí odkaz:
https://doaj.org/article/9b4fe8db375a46b7866a7e7fdbbb10fc
Autor:
Bradley T. Hyman, Gerard D. Schellenberg, Jean Paul Vonsattel, Yinghua Chen, Matthew J. Huentelman, Thomas G. Beach, Julie A. Schneider, Walter A. Kukull, M. Ilyas Kamboh, Bernardino Ghetti, Richard J. Caselli, Kathryn L. Lunetta, Yi Su, John Q. Trojanowski, Eric B. Larson, Julia Kofler, John Hardy, John Gilbert, Amanda J. Myers, Margaret A. Pericak-Vance, Thomas J. Montine, Richard Mayeux, Paul K. Crane, Joseph D. Buxbaum, Yakeel T. Quiroz, Linda Duque, Steven G. Younkin, David A. Bennett, Matthew P. Frosch, Tatiana Foroud, Lindsay A. Farrer, Joseph F. Arboleda-Velasquez, Harry E. Gwirtsman, Philip L. De Jager, Jonathan L. Haines, C. Dirk Keene, Dennis W. Dickson, Eric M. Reiman, Gyungah Jun, Li-San Wang, Gary W. Beecham
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, such that APOE4 homozygotes have a particularly high risk. While the APOE2 allele is associated with a lower risk of Alzheimer’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f1adfe4f1914100e92fd87410ffa8b
https://doi.org/10.1101/19011015
https://doi.org/10.1101/19011015
Autor:
Eric M, Reiman, Joseph F, Arboleda-Velasquez, Yakeel T, Quiroz, Matthew J, Huentelman, Thomas G, Beach, Richard J, Caselli, Yinghua, Chen, Yi, Su, Amanda J, Myers, John, Hardy, Jean, Paul Vonsattel, Steven G, Younkin, David A, Bennett, Philip L, De Jager, Eric B, Larson, Paul K, Crane, C Dirk, Keene, M Ilyas, Kamboh, Julia K, Kofler, Linda, Duque, John R, Gilbert, Harry E, Gwirtsman, Joseph D, Buxbaum, Dennis W, Dickson, Matthew P, Frosch, Bernardino F, Ghetti, Kathryn L, Lunetta, Li-San, Wang, Bradley T, Hyman, Walter A, Kukull, Tatiana, Foroud, Jonathan L, Haines, Richard P, Mayeux, Margaret A, Pericak-Vance, Julie A, Schneider, John Q, Trojanowski, Lindsay A, Farrer, Gerard D, Schellenberg, Gary W, Beecham, Thomas J, Montine, Gyungah R, Jun, Yi, Zhao
Publikováno v:
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer’s dementia, while the APOE2 allele is associated with a lower risk of Alzheimer’s dementia, it is not yet known whether APOE2 homozygotes h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7342a79d4903dea612b69ce04a4cbb7e
https://pubmed.ncbi.nlm.nih.gov/32015339
https://pubmed.ncbi.nlm.nih.gov/32015339
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6600637652105ad924625bbcf1c56f
https://doi.org/10.1016/j.jalz.2018.06.127
https://doi.org/10.1016/j.jalz.2018.06.127
Publikováno v:
Alzheimer's & Dementia. 15:P899-P900
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::794818405f92e4daa67414fa66de5170
https://doi.org/10.1016/j.jalz.2019.06.4665
https://doi.org/10.1016/j.jalz.2019.06.4665
Publikováno v:
The American Journal of Geriatric Psychiatry. 27:S187-S188
Introduction Subjective cognitive decline (SCD) is increasingly recognized as the initial outward sign of preclinical Alzheimer's disease. The ability to explore associations between individual domains (memory, language, executive function, and visuo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7b3bea59646249042eaa2a18e76906
https://doi.org/10.1016/j.jagp.2019.01.101
https://doi.org/10.1016/j.jagp.2019.01.101
Recent Alzheimer's trials have recruited cognitively normal people at risk for Alzheimer's dementia. Due to the lack of clinical symptoms in normal population, conventional clinical outcome measures are not suitable for these early trials. While seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452573a9c4a4351e4bb5235f0ed60953
https://europepmc.org/articles/PMC5958602/
https://europepmc.org/articles/PMC5958602/
Autor:
Dennis E. Schmidt, John F Gouda, Benjamin W. Johnson, Richard Shiavi, Joseph Kwentus, John S. Kennedy, Ronald M. Salomon, Jennifer Urbano Blackford, Harry E. Gwirtsman
Publikováno v:
Neuropsychopharmacology. 30:2082-2091
Unipolar and bipolar depressions show abnormal behavioral manifestations of ultradian (less than 24 h) rhythms, but abnormal rhythms of the central neurotransmitters thought to be important for depression pathophysiology (eg dopamine (DA) and seroton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14a74c9770d551ace77097f08c9912a
https://doi.org/10.1038/sj.npp.1300746
https://doi.org/10.1038/sj.npp.1300746