Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Harry E. Boddé"'
Publikováno v:
Pharmaceutical Research. 18:1012-1017
Purpose. To study at the ultrastructural level which part of the skin is associated with percutaneous iodide transport by passive diffusion and iontophoresis.
Publikováno v:
Microscopy Research and Technique. 47:286-290
A single autoradiographical method for light and electron microscopy (LM and EM) is presented. Human skin, containing 3H-estradiol (3H-E2) after an in vitro permeation experiment, was processed via a non-extractive tissue preparation protocol, compri
Publikováno v:
Advanced Drug Delivery Reviews. 33:253-263
R-apomorphine is a mixed dopamine D1/D2 receptor agonist which is potentially useful in the management of Parkinson's disease. The delivery of R-apomorphine is complicated however by a number of pharmacokinetic and pharmacodynamic factors. This revie
Publikováno v:
Journal of Investigative Dermatology Symposium Proceedings. 3(2):180-184
HaCaT cell culture sheets were recently demonstrated to be a useful tool to study epidermal metabolism. Here we report on a mechanistic and quantitative correlation between the kinetics of aminopeptidase-based cleavage of L-Ala-4-methoxy-2-naphthylam
Publikováno v:
Skin Pharmacology and Physiology. 11:11-22
A study was made of the validity of freeze-drying to visualize the distribution of 3H-estradiol in human stratum corneum after topical application of a dry dose, a patch or a buffer solution. Each of these donor formulations was applied to human derm
Publikováno v:
Skin Pharmacology and Physiology. 11:87-97
The in vivo effects of fatty acids on skin barrier function were assessed by measuring: (i) transepidermal water loss (TEWL), (ii) diffusion lag times for hexyl nicotinate (HN), and (iii) irritant skin response using laser Doppler velocimetry (LDV) i
Publikováno v:
Toxicology in Vitro. 11:365-376
A human skin equivalent (HSE) consisting of reconstructed epidermis on a fibroblast-populated collagen gel was evaluated as a model for irritancy screening. The irritancy potential of a series of saturated and unsaturated fatty acids was investigated
Autor:
Christopher A. Squier, A. Janet Hoogstraate, William Abraham, Harry E. Boddé, Mike D Garrison, J. Coos Verhoef, Hans E. Junginger, Phil W Wertz, Anita Bos-van Geest
Publikováno v:
European Journal of Pharmaceutical Sciences. 5:189-198
The concentration dependence of the transport enhancing effect of sodium glycodeoxycholate (GDC) on the structural integrity of porcine buccal epithelium was studied in vitro. Lipid analysis of the buccal epithelium indicated that the epithelial lipi
Publikováno v:
Journal of Controlled Release. 47:31-39
The skin barrier function can be evaluated by measuring the rate of transepidermal water loss (TEWL). This technique can also be used to elucidate the effect of enhancers on the skin barrier. In this in vivo study the effect of oleic acid in propylen
Autor:
Gert S. Gooris, J. Coos Verhoef, Hans E. Junginger, Ine W.H.M. Craane-Van Hinsberg, F. Spies, Harry E. Boddé, Joke A. Bouwstra
Publikováno v:
Microscopy Research and Technique. 37:200-213
In transdermal iontophoresis, drugs can be driven across the skin by electrorepulsion, but their transport can also be enhanced by electrical perturbation of the skin barrier. Our objective was to study perturbing effects of electrical current on hum