Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Harry Begthel"'
Autor:
Sangho Lim, Gijs J. F. van Son, Ni Luh Wisma Eka Yanti, Amanda Andersson-Rolf, Sam Willemsen, Jeroen Korving, Hong-Gyun Lee, Harry Begthel, Hans Clevers
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114019- (2024)
Summary: Thymic epithelial cells (TECs) orchestrate T cell development by imposing positive and negative selection on thymocytes. Current studies on TEC biology are hampered by the absence of long-term ex vivo culture platforms, while the cells drivi
Externí odkaz:
https://doaj.org/article/4e939fc710f34c5baa9c4a569aa45c17
Tubuloid differentiation to model the human distal nephron and collecting duct in health and disease
Autor:
Fjodor A. Yousef Yengej, Carla Pou Casellas, Carola M.E. Ammerlaan, Charlotte J.A. Olde Hanhof, Emre Dilmen, Joep Beumer, Harry Begthel, Elise M.G. Meeder, Joost G. Hoenderop, Maarten B. Rookmaaker, Marianne C. Verhaar, Hans Clevers
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113614- (2024)
Summary: Organoid technology is rapidly gaining ground for studies on organ (patho)physiology. Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The progenitor state of expanding tubuloids comes at the expense of di
Externí odkaz:
https://doaj.org/article/0b0f29d1d0104197b48e1e0d9de49d2d
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids
Autor:
Maarten H. Geurts, Shashank Gandhi, Matteo G. Boretto, Ninouk Akkerman, Lucca L. M. Derks, Gijs van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M. Chuva de Sousa Lopes, Johan H. van Es, Ruben van Boxtel, Hans Clevers
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Optimization of CRISPR/Cas9-mediated genome engineering has resulted in base editors that hold promise for mutation repair and disease modeling. Here, we demonstrate the application of base editors for the generation of complex tumor models
Externí odkaz:
https://doaj.org/article/118466422c7b4a548268957a251cfb11
Autor:
Sander Mertens, Maarten A. Huismans, Carla S. Verissimo, Bas Ponsioen, Rene Overmeer, Natalie Proost, Olaf van Tellingen, Marieke van de Ven, Harry Begthel, Sylvia F. Boj, Hans Clevers, Jeanine M.L. Roodhart, Johannes L. Bos, Hugo J.G. Snippert
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112324- (2023)
Summary: Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify hidden vulnerabilities with
Externí odkaz:
https://doaj.org/article/90d447bcda174d4aba2b71aaf83d4fbd
Autor:
Kadi Lõhmussaar, Oded Kopper, Jeroen Korving, Harry Begthel, Celien P. H. Vreuls, Johan H. van Es, Hans Clevers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The relative contribution of fallopian tube (FT) or ovarian surface epithelium (OSE) to high-grade serous ovarian cancer (HG-SOC) development is unclear. Here, the authors establish organoid models from murine oviductal and OSE tissues that allow can
Externí odkaz:
https://doaj.org/article/b561dc387d334f75b89e8a94ccc8b593
Autor:
Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L. van Ineveld, Sepide Derakhshan, Sanne de Haan, Emmy Dolman, Philip Lijnzaad, Lars Custers, Harry Begthel, Hindrik H. D. Kerstens, Lindy L. Visser, Maarten Rookmaaker, Marianne Verhaar, Godelieve A. M. Tytgat, Patrick Kemmeren, Ronald R. de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Marcel Kool, Anne C. Rios, Marry M. van den Heuvel-Eibrink, Jan J. Molenaar, Ruben van Boxtel, Frank C. P. Holstege, Hans Clevers, Jarno Drost
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different
Externí odkaz:
https://doaj.org/article/06e35408aaed4de9ae4266eeecb8d988
Autor:
Georg A. Busslinger, Bas L.A. Weusten, Auke Bogte, Harry Begthel, Lodewijk A.A. Brosens, Hans Clevers
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108819- (2021)
Summary: The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum, controls food transport, digestion, nutrient uptake, and hormone production. By single-cell analysis of healthy epithelia of these human organs, we molecul
Externí odkaz:
https://doaj.org/article/b77a2edf428f44928a5f69caf4aacd8d
Patient-derived pancreatic tumour organoids identify therapeutic responses to oncolytic adenoviruses
Autor:
Giulia Raimondi, Ana Mato-Berciano, Silvia Pascual-Sabater, Maria Rovira-Rigau, Miriam Cuatrecasas, Constantino Fondevila, Santiago Sánchez-Cabús, Harry Begthel, Sylvia F. Boj, Hans Clevers, Cristina Fillat
Publikováno v:
EBioMedicine, Vol 56, Iss , Pp 102786- (2020)
Background: Pancreatic patient–derived organoids (PDOs) are a well-established model for studying pancreatic ductal adenocarcinoma (PDAC) carcinogenesis and are potential predictors of clinical responses to chemotherapy. Oncolytic virotherapy is en
Externí odkaz:
https://doaj.org/article/54b0579e90bc4533acf9a74474c5a28f
Autor:
Nesrin Tüysüz, Louis van Bloois, Stieneke van den Brink, Harry Begthel, Monique M. A. Verstegen, Luis J. Cruz, Lijian Hui, Luc J. W. van der Laan, Jeroen de Jonge, Robert Vries, Eric Braakman, Enrico Mastrobattista, Jan J. Cornelissen, Hans Clevers, Derk ten Berge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
There are two technical impediments for using purified Wnt proteins in serum-free stem cell cultures: rapid loss of activity and toxicity of detergents to stem cell self-renewal. Here, the authors show that lipid-stabilized Wnt3a can establish long-t
Externí odkaz:
https://doaj.org/article/c1491917e9fe4c3fa3f5944fd3318bf1
Autor:
Tokameh Mahmoudi, Sylvia F Boj, Pantelis Hatzis, Vivian S W Li, Nadia Taouatas, Robert G J Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J R Heck, Hans Clevers
Publikováno v:
PLoS Biology, Vol 15, Iss 2, p e1002596 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.1000539.].
Externí odkaz:
https://doaj.org/article/62c1db93ed6448449dcd4f427ae3ddea