Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harry B. Marr"'
Autor:
Harry B. Marr, Kevin P. Madauss, Jonathan Y. Bass, Shawn P. Williams, Dan Todd, Paul Kenneth Spearing, Adwoa Akwabi-Ameyaw, Lihong Chen, Robert B. McFadyen, Justin A. Caravella, Derek J. Parks, Frank Navas, David N. Deaton, Katrina L. Creech, G. Bruce Wisely, Richard Dana Caldwell, Aaron B. Miller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4733-4739
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537fc0c9b0822e4038f1ffd07428e5e6
https://doi.org/10.1016/j.bmcl.2009.06.062
https://doi.org/10.1016/j.bmcl.2009.06.062
Autor:
Lihong Chen, Jonathan Y. Bass, David N. Deaton, Aaron B. Miller, Justin A. Caravella, Istvan Kaldor, Robert B. McFadyen, Stacey A. Jones, Dan Todd, Paul Kenneth Spearing, Kevin P. Madauss, Adwoa Akwabi-Ameyaw, Derek J. Parks, Richard Dana Caldwell, Frank Navas, Yaping Liu, Katrina L. Creech, G. Bruce Wisely, Harry B. Marr, Shawn P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4339-4343
Starting from the known FXR agonist GW 4064 1a, a series of stilbene replacements were prepared. The 6-substituted 1-naphthoic acid 1b was an equipotent FXR agonist with improved developability parameters relative to 1a. Analog 1b also reduced the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519480e527d445babf5d509d5d05a857
https://doi.org/10.1016/j.bmcl.2008.06.073
https://doi.org/10.1016/j.bmcl.2008.06.073
Autor:
Aaron B. Miller, Harry B. Marr, Katrina L. Creech, G. Bruce Wisely, Shawn P. Williams, Adwoa Akwabi-Ameyaw, Lihong Chen, David N. Deaton, Justin A. Caravella, Paul Kenneth Spearing, Kevin P. Madauss, Derek J. Parks, Frank Navas, Dan Todd
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(20)
To further explore the optimum placement of the acid moiety in conformationally constrained analogs of GW 4064 1a, a series of stilbene replacements were prepared. The benzothiophene 1f and the indole 1g display the optimal orientation of the carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f939259f5c374490a071b94fee47ab3
https://pubmed.ncbi.nlm.nih.gov/21890356
https://pubmed.ncbi.nlm.nih.gov/21890356
Autor:
Justin A. Caravella, Terrence L. Smalley, Jonathan Y. Bass, Kevin P. Madauss, Aaron B. Miller, Robert B. McFadyen, Katrina L. Creech, G. Bruce Wisely, Harry B. Marr, Lihong Chen, Dan Todd, Shawn P. Williams, David N. Deaton, Paul Kenneth Spearing, Derek J. Parks, Frank Navas, Wendy Y. Mills
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(4)
To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fde8626b56404560d9578dd0bfc42d
https://pubmed.ncbi.nlm.nih.gov/21256005
https://pubmed.ncbi.nlm.nih.gov/21256005
Autor:
Alshaimaa Hassan-Abdallah, Jennifer Poole Peckham, Yikang Wang, Harry B. Marr, Richard J. Hazen, Jan Balzarini, S Srinivasan, Huiqiang Zhou, Christopher McGuigan, Adam Siddiqui, Ed W. McLean, Kristjan Gudmundsson, Lynn D. Condreay, Lance C. Johnson, Susan Daluge, Thimysta C. Burnette
Publikováno v:
Journal of medicinal chemistry. 49(24)
We report the application of phosphoramidate pronucleotide (ProTide) technology to the antiviral agent carbocyclic L-d4A (L-Cd4A). The phenyl methyl alaninyl parent ProTide of L-Cd4A was prepared by Grignard-mediated phosphorochloridate reaction and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7824881a4d809b81a6bb35631e73c45
https://pubmed.ncbi.nlm.nih.gov/17125274
https://pubmed.ncbi.nlm.nih.gov/17125274
Autor:
Steven S. Good, Allen W. Mangel, Susan Mary Daluge, Gerald Wolberg, Brian E. Huber, Marie A. Iannone, Harry B. Marr, Jeffrey L. Selph, Nicholas W. Lerche, Jurgensen Cynthia Holder, Kay Washington
Publikováno v:
Gastroenterology. 118:A863
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d386bcc9997beea314c59ea50a14bf38
https://doi.org/10.1016/s0016-5085(00)85594-8
https://doi.org/10.1016/s0016-5085(00)85594-8
Autor:
Richard E. Hall, Harry B. Marr
Publikováno v:
Brain research. 93(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2384cfb431819aa183ec998d46b3babc
https://pubmed.ncbi.nlm.nih.gov/809103
https://pubmed.ncbi.nlm.nih.gov/809103
Publikováno v:
Steroids. 39(6)
We report an assay for testicular 17,20-lyase which depends on the use of [21-14C]progesterone as a substrate. The method is made possible by a simplified procedure for the synthesis of [21-14C]progesterone. A chromatographic separation of the unreac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7449bbfca5aa3f3ebdfb3d5a28839257
https://pubmed.ncbi.nlm.nih.gov/7157434
https://pubmed.ncbi.nlm.nih.gov/7157434
Publikováno v:
Pediatric research. 18(8)
A double-label, double-substrate incubation technique has been developed and used to study the conversion of progesterone to testosterone in testes extracts from incompletely virilized males. The procedure involves separation of the microsomes from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b0d30806ca01d01b74ffbb2c76fa41
https://pubmed.ncbi.nlm.nih.gov/6332300
https://pubmed.ncbi.nlm.nih.gov/6332300