Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Harry B. Gristick"'
Autor:
Kim-Marie A. Dam, Christopher O. Barnes, Harry B. Gristick, Till Schoofs, Priyanthi N. P. Gnanapragasam, Michel C. Nussenzweig, Pamela J. Bjorkman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
VRC01-class bNAbs against the CD4 binding site of HIV-1 Env are targets of vaccine design. Here, the authors structurally characterized germline versions of the VRC01-class bNAb, BG24, bound to Env. They reveal mechanisms of germline binding, informi
Externí odkaz:
https://doaj.org/article/84617c38677f4ed9a47137ef00a43a98
Autor:
Zhi Yang, Kim-Marie A. Dam, Michael D. Bridges, Magnus A. G. Hoffmann, Andrew T. DeLaitsch, Harry B. Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A. Martin, Michel C. Nussenzweig, Wayne L. Hubbell, Pamela J. Bjorkman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Neutralizing antibodies (bNAbs) against HIV-1 are exclusively directed against the viral envelope protein (Env) and mainly target Env in a closed, prefusion state. Here, Yang et al. structurally characterize two heterologously-neutralizing CD4-bindin
Externí odkaz:
https://doaj.org/article/a3f529a3512548c399bdcaadfab62202
Autor:
Morgan E. Abernathy, Harry B. Gristick, Jost Vielmetter, Jennifer R. Keeffe, Priyanthi N. P. Gnanapragasam, Yu E. Lee, Amelia Escolano, Rajeev Gautam, Michael S. Seaman, Malcolm A. Martin, Michel C. Nussenzweig, Pamela J. Bjorkman
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target ant
Externí odkaz:
https://doaj.org/article/dc207aad5e0148e593ea440eea90a943
Autor:
Christopher O. Barnes, Harry B. Gristick, Natalia T. Freund, Amelia Escolano, Artem Y. Lyubimov, Harald Hartweger, Anthony P. West, Aina E. Cohen, Michel C. Nussenzweig, Pamela J. Bjorkman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Structure determination of glycosylated HIV-1 envelope (Env) trimers complexed with broadly neutralizing antibodies (bNAbs) promotes a better understanding of bNAb epitopes. Here the authors present the structures of natively-glycosylated Env in comp
Externí odkaz:
https://doaj.org/article/7030291af4434b7f82b5c09a827a0481
Autor:
Zijun Wang, Christopher O Barnes, Rajeev Gautam, Julio C Cetrulo Lorenzi, Christian T Mayer, Thiago Y Oliveira, Victor Ramos, Melissa Cipolla, Kristie M Gordon, Harry B Gristick, Anthony P West, Yoshiaki Nishimura, Henna Raina, Michael S Seaman, Anna Gazumyan, Malcolm Martin, Pamela J Bjorkman, Michel C Nussenzweig, Amelia Escolano
Publikováno v:
eLife, Vol 9 (2020)
A small fraction of HIV-1- infected humans develop broadly neutralizing antibodies (bNAbs) against HIV-1 that protect macaques from simian immunodeficiency HIV chimeric virus (SHIV). Similarly, a small number of macaques infected with SHIVs develop b
Externí odkaz:
https://doaj.org/article/3f5503aa317c4cc98f201aea287fdd1f
Autor:
Harry B. Gristick, Harald Hartweger, Maximilian Loewe, Jelle van Schooten, Victor Ramos, Thiago Y. Oliveira, Yoshiaki Nishimura, Nicholas S. Koranda, Abigail Wall, Kai-Hui Yao, Daniel Poston, Anna Gazumyan, Marie Wiatr, Marcel Horning, Jennifer R. Keeffe, Magnus A. G. Hoffmann, Zhi Yang, Morgan E. Abernathy, Kim-Marie A. Dam, Han Gao, Priyanthi N. P. Gnanapragasam, Leesa M. Kakutani, Ana Jimena Pavlovitch-Bedzyk, Michael S. Seaman, Mark Howarth, Andrew T. McGuire, Leonidas Stamatatos, Malcolm A. Martin, Anthony P. West, Michel C. Nussenzweig, Pamela J. Bjorkman
Passive transfer of broadly neutralizing anti–HIV-1 antibodies (bNAbs) protects against infection, and therefore, eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. bNAbs that target the CD4 binding site (CD4bs) on HIV-1 Env a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdfea6435d8275600e0a5a354868641
Autor:
Jost Vielmetter, Michel C. Nussenzweig, Jennifer R. Keeffe, Priyanthi N. P. Gnanapragasam, Rajeev Gautam, Michael S. Seaman, Pamela J. Bjorkman, Amelia Escolano, Malcolm A. Martin, Morgan E. Abernathy, Yu E. Lee, Harry B. Gristick
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
NPJ Vaccines
NPJ Vaccines
HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target antibody aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b965d4decbe92e214e5d17e9fcd1aa8d
https://doaj.org/article/dc207aad5e0148e593ea440eea90a943
https://doaj.org/article/dc207aad5e0148e593ea440eea90a943
Autor:
Haoqing Wang, Harry B Gristick, Louise Scharf, Anthony P West Jr, Rachel P Galimidi, Michael S Seaman, Natalia T Freund, Michel C Nussenzweig, Pamela J Bjorkman
Publikováno v:
eLife, Vol 6 (2017)
The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplif
Externí odkaz:
https://doaj.org/article/ce79500b073a47d8b67674c7bca40338
Publikováno v:
Nature structural & molecular biology
The human immunodeficiency virus (HIV-1) envelope (Env) glycoprotein, a (gp120–gp41)3 trimer, mediates fusion of viral and host cell membranes after gp120 binding to host receptor CD4. Receptor binding triggers conformational changes allowing corec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e5c25bdf53e1f016a80b7e2bab7941
https://doi.org/10.1038/s41594-019-0344-5
https://doi.org/10.1038/s41594-019-0344-5
Autor:
Andrew T. DeLaitsch, Nicholas Koranda, Murillo Silva, Han Gao, Leesa M. Kakutani, Amelia Escolano, Morgan E. Abernathy, Melissa Cipolla, Priyanthi N. P. Gnanapragasam, Thiago Y. Oliveira, Zhi Yang, Christopher O. Barnes, Jennifer R. Keeffe, Malcolm A. Martin, Zijun Wang, Michel C. Nussenzweig, Michael S. Seaman, Ana Gazumyan, Henna Raina, Darrell J. Irvine, Rajeev Gautam, Haoqing Wang, Pamela J. Bjorkman, Victor A. Ramos, Magnus A.G. Hoffmann, Anthony P. West, Harry B. Gristick, Yoshiaki Nishimura
Publikováno v:
Sci Transl Med
Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and antibody co-evolution. Previous studies showed that sequential immunization with a V3-glycan-patch germline-targeting HIV-1 envelope trimer (Env) followed by vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccd03a11a1f95bb633c87e9a2975f7d
https://resolver.caltech.edu/CaltechAUTHORS:20211124-195820111
https://resolver.caltech.edu/CaltechAUTHORS:20211124-195820111