Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Harry A T Pritchard"'
Autor:
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Barry W McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B Lawrence, Cheryl Hawkes, Chrysia-Maria Pegasiou-Davies, Claire Gibson, Colin L Crawford, Colin Smith, Denis Vivien, Fiona H McLean, Frances Wiseman, Gaia Brezzo, Giovanna Lalli, Harry A T Pritchard, Hugh S Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S Stringer, MLJ Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H Hainsworth, Joanna M Wardlaw
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 5, Iss , Pp 100189- (2023)
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which e
Externí odkaz:
https://doaj.org/article/9ffe49ccbd5b476183d732a9dab4e59d
Autor:
Viktoria Csato, Sharifah Z. S. A. Kadir, Kaivan Khavandi, Hayley Bennett, Sarah Sugden, Alison M. Gurney, Harry A. T. Pritchard, David Hill‐Eubanks, Philip Eaton, Mark T. Nelson, Adam S. Greenstein
Publikováno v:
Physiological Reports, Vol 7, Iss 22, Pp n/a-n/a (2019)
Abstract We investigated the biomechanical relationship between intraluminal pressure within small mesenteric resistance arteries, oxidant activation of PKG, Ca2+ sparks, and BK channel vasoregulation. Mesenteric resistance arteries from wild type (W
Externí odkaz:
https://doaj.org/article/8785c9dfa9f3404c9c302b284da289f5
Autor:
Jade L Taylor, Lowri E Evans, Harry A. T. Pritchard, Adam Greenstein, Craig J. Smith, Stuart M. Allan
Publikováno v:
Cardiovascular Research.
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and affects all levels of the brain’s vasculature. Features include diverse structural and functional changes affecting small arteries and capillaries th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3de8488782fd33dc326ce7d418fe2b
https://doi.org/10.1093/cvr/cvab284
https://doi.org/10.1093/cvr/cvab284
Autor:
Harry A. T. Pritchard, Pratish Thakore, Caoimhin S. Griffin, Scott Earley, Conor Lane, Adam Greenstein, Evan Yamasaki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Pritchard, H A T, Griffin, C S, Yamasaki, E, Thakore, P, Lane, C, Greenstein, A S & Earley, S 2019, ' Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 43, pp. 21874-21881 . https://doi.org/10.1073/pnas.1911304116
Pritchard, H A T, Griffin, C S, Yamasaki, E, Thakore, P, Lane, C, Greenstein, A S & Earley, S 2019, ' Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 43, pp. 21874-21881 . https://doi.org/10.1073/pnas.1911304116
Significance The junctophilins are a family of structural proteins that organize intracellular membrane junctions, such as coupling between the endoplasmic/sarcoplasmic reticulum and plasma membrane. The junctophilins are critically important for car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40baf60a7196d9b30773d05a7216436
http://europepmc.org/articles/PMC6815135
http://europepmc.org/articles/PMC6815135
Autor:
Alexander E. P. Heazell, Stephanie Worton, Adam Greenstein, Susan L. Greenwood, Jenny Myers, Mariam Alakrawi, Harry A. T. Pritchard, Mark Wareing
Publikováno v:
Worton, S A, Pritchard, H A, Greenwood, S L, Alakrawi, M, Heazell, A E, Wareing, M, Greenstein, A S & Myers, J E 2021, ' Kynurenine Relaxes Arteries of Normotensive Women and Those with Preeclampsia ', Circulation research . https://doi.org/10.1161/CIRCRESAHA.120.317612
Circulation Research
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: Activation of the kynurenine pathway of tryptophan catabolism by infection and inflammation contributes to the development of systemic hypotension. Commercially-available kynureni
Rationale: Activation of the kynurenine pathway of tryptophan catabolism by infection and inflammation contributes to the development of systemic hypotension. Commercially-available kynureni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782bf8f82f4ab13eb5c6e74791a29a19
https://www.research.manchester.ac.uk/portal/en/publications/kynurenine-relaxes-arteries-of-normotensive-women-and-those-with-preeclampsia(46c57903-715e-483e-9502-a717185b9b5f).html
https://www.research.manchester.ac.uk/portal/en/publications/kynurenine-relaxes-arteries-of-normotensive-women-and-those-with-preeclampsia(46c57903-715e-483e-9502-a717185b9b5f).html
Autor:
Cam Ha T. Tran, Paulo W. Pires, Brant E. Isakson, Sher Ali, Scott Earley, Evan Yamasaki, Harry A. T. Pritchard, Michael G. Alvarado, Pratish Thakore, Amreen Mughal
Blood flow regulation in the brain is dynamically regulated to meet the metabolic demands of active neuronal populations. Recent evidence has demonstrated that capillary endothelial cells are essential mediators of neurovascular coupling that sense n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f1f9db53bbf7ffefea8169b9bd45c41
https://doi.org/10.1101/2020.09.14.295600
https://doi.org/10.1101/2020.09.14.295600
Autor:
Paulo W. Pires, Sher Ali, Cam Ha T. Tran, Harry A. T. Pritchard, Amreen Mughal, Michael G. Alvarado, Brant E. Isakson, Evan Yamasaki, Pratish Thakore, Scott Earley
Publikováno v:
Cell Calcium
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
eLife
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1319237c6394100b70b68531d064f61b
https://pubmed.ncbi.nlm.nih.gov/33848732
https://pubmed.ncbi.nlm.nih.gov/33848732
Autor:
Pratish, Thakore, Harry A T, Pritchard, Caoimhin S, Griffin, Evan, Yamasaki, Bernard T, Drumm, Conor, Lane, Kenton M, Sanders, Yumei, Feng Earley, Scott, Earley
Publikováno v:
Sci Signal
In this issue of Science Signaling, Thakore et al. report that the Ca(2+) permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca(2+) sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8adc4abcbf753ee63a02289dd5a9b6d
https://pubmed.ncbi.nlm.nih.gov/32576679
https://pubmed.ncbi.nlm.nih.gov/32576679
Autor:
Evan Yamasaki, Kenton M. Sanders, Bernard T. Drumm, Conor Lane, Harry A. T. Pritchard, Caoimhin S. Griffin, Scott Earley, Yumei Feng Earley, Pratish Thakore
Publikováno v:
Science Signaling. 13
TRPML1 (transient receptor potential mucolipin 1) is a Ca2+-permeable, nonselective cation channel localized to the membranes of endosomes and lysosomes and is not present or functional on the plasma membrane. Ca2+ released from endosomes and lysosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e99720f01c4d23a833712da2dcc3fd
https://doi.org/10.1126/scisignal.aba1015
https://doi.org/10.1126/scisignal.aba1015
Autor:
Scott Earley, Paulo W. Pires, Evan Yamasaki, Eun-A. Ko, Harry A. T. Pritchard, Michael Rudokas
Publikováno v:
The Journal of Physiology. 595:4735-4753
KEY POINTS The angiotensin II receptor type 1b (AT1 Rb ) is the primary sensor of intraluminal pressure in cerebral arteries. Pressure or membrane-stretch induced stimulation of AT1 Rb activates the TRPM4 channel and results in inward transient catio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1e4ec3bfeedcf9345b8e8edd72431f
https://doi.org/10.1113/jp274310
https://doi.org/10.1113/jp274310