Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Harry, Costello"'
Publikováno v:
Cognitive Neuropsychiatry. :1-10
Publikováno v:
Psychological Medicine. 53:654-667
Depression in dementia is common, disabling and causes significant distress to patients and carers. Despite widespread use of antidepressants for depression in dementia, there is no evidence of therapeutic efficacy, and their use is potentially harmf
Publikováno v:
BJPsych Open, Vol 6 (2020)
To date, there have been no detailed reports of patients developing persistent psychotic symptoms following Coronavirus disease 2019 (COVID-19) infection. There have been reports of patients developing transient delirium (with and without hypoxia) af
Externí odkaz:
https://doaj.org/article/31677f4e8c7e4cce88b6d03dfe30d89b
Apathy is a disabling syndrome associated with poor functional outcomes that is common across a broad range of neurological and psychiatric conditions. Currently there are no established therapies specifically for apathy, and safe and effective treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86bd5e33925cbdbd46275863a8436487
https://doi.org/10.31234/osf.io/m3vjy
https://doi.org/10.31234/osf.io/m3vjy
Publikováno v:
Biological Psychiatry. 93:S246-S247
Autor:
Rimona Weil, Jonathan Roiser, Eileen Joyce, Robert Howard, Alex Berry, Harry Costello, Suzanne Reeves
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 93:555-562
BackgroundNeuropsychiatric symptoms are common in Parkinson’s disease (PD) and predict poorer outcomes. Reward processing dysfunction is a candidate mechanism for the development of psychiatric symptoms including depression and impulse control diso
Autor:
Jonathan Roiser, Robert Howard, Anette Schrag, Harry Costello, Suzanne Reeves, Yumeya Yamamori
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. :jnnp-2022
SummaryBackgroundMotivational symptoms such as apathy and anhedonia are common in Parkinson’s disease, respond poorly to treatment, and have been hypothesised to share underlying neural mechanisms. Striatal dopaminergic dysfunction is considered ce
Autor:
Suzanne Reeves, Harry Costello, Kathy Y. Liu, Robert Howard, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
J Alzheimers Dis
Background: Agitation in Alzheimer’s disease (AD) has been hypothesized to be an expression of anxiety, but whether anxiety early in the course of dementia could be a risk factor for developing later agitation is unknown. Objective: We used the Alz
Autor:
Sanjeev Rajakulendran, Robert D S Pitceathly, Jan-Willem Taanman, Harry Costello, Mary G Sweeney, Cathy E Woodward, Zane Jaunmuktane, Janice L Holton, Thomas S Jacques, Brian N Harding, Carl Fratter, Michael G Hanna, Shamima Rahman
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145500 (2016)
Mutations in the nuclear gene POLG (encoding the catalytic subunit of DNA polymerase gamma) are an important cause of mitochondrial disease. The most common POLG mutation, A467T, appears to exhibit considerable phenotypic heterogeneity. The mechanism
Externí odkaz:
https://doaj.org/article/ec6375b1818241cab0f1ce4c29b4eb0c
Publikováno v:
Age and Ageing
Background staff burnout and turnover lead to care home residents receiving poorer quality care. Burnout is thought to cause turnover, but this has never been investigated. We know little about which care home staffs are burnt out. Aims to explore bu