Investigating the mechanisms and elements responsible for regulatory domain formation during gene regulation

Autor: Harrold, CL

The genome is a highly organised and complex structure; it is separated into distinct chromatin domains whose structures influence transcriptional regulation. Regulatory domains contain the promoters of active genes and their cis-regulatory elements,

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https://ora.ox.ac.uk/objects/uuid:71fdc5ce-0898-413e-ab26-2c7014b813ac

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.

Autor: Oudelaar AM; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Harrold CL; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hanssen LLP; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Telenius JM; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Higgs DR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hughes JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. jim.hughes@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2019 Nov 27; Vol. 10 (1), pp. 5412. Date of Electronic Publication: 2019 Nov 27.

Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.

Autor: Kurioka A; Nuffield Department of Medicine, University of Oxford, Oxford., van Wilgenburg B; Nuffield Department of Medicine, University of Oxford, Oxford., Javan RR; Nuffield Department of Medicine, University of Oxford, Oxford., Hoyle R; Nuffield Department of Medicine, University of Oxford, Oxford., van Tonder AJ; Nuffield Department of Medicine, University of Oxford, Oxford., Harrold CL; Nuffield Department of Medicine, University of Oxford, Oxford., Leng T; Nuffield Department of Medicine, University of Oxford, Oxford., Howson LJ; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford., Shepherd D; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford., Cerundolo V; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford., Brueggemann AB; Nuffield Department of Medicine, University of Oxford, Oxford.; Department of Medicine, Imperial College London, London, United Kingdom., Klenerman P; Nuffield Department of Medicine, University of Oxford, Oxford.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2018 Mar 05; Vol. 217 (6), pp. 988-999.

MAIT cells in bacterial infectious diseases: heroes, villains, or both?

Autor: Wu, Sihong¹ (AUTHOR), Yang, Xi¹ (AUTHOR), Lou, Yongliang¹ (AUTHOR) lyl@wmu.edu.cn, Xiao, Xingxing¹ (AUTHOR) xiaoxingxing@wmu.edu.cn

Publikováno v: Clinical & Experimental Immunology. Nov2023, Vol. 214 Issue 2, p144-153. 10p.

Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA.

Autor: Kwun, Min Jung¹ (AUTHOR), Ion, Alexandru V.¹ (AUTHOR), Cheng, Hsueh-Chien² (AUTHOR), D'Aeth, Joshua C.¹ (AUTHOR), Dougan, Sam² (AUTHOR), Oggioni, Marco R.^3,4 (AUTHOR), Goulding, David A.² (AUTHOR), Bentley, Stephen D.² (AUTHOR), Croucher, Nicholas J.¹ (AUTHOR) n.croucher@imperial.ac.uk

Publikováno v: Genome Medicine. 12/20/2022, Vol. 14 Issue 1, p1-23. 23p.