Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.

Autor: Biswas S; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Tumor Immunology and Immunotherapy, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India., Mandal G; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Division of Cancer Biology, DBT-Institute of Life Sciences, Bhubaneswar 751023, India., Anadon CM; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Chaurio RA; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Lopez-Bailon LU; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Nagy MZ; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Mine JA; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Hänggi K; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Sprenger KB; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Innamarato P; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Harro CM; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Powers JJ; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Johnson J; Analytic Microscopy Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Fang B; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Eysha M; Department of Medicine, Duke School of Medicine, Durham, NC 27710, USA., Nan X; Department of Biomedical Engineering, Knight Cancer Institute, and OHSU Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR 97239, USA., Li R; Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Perez BA; Department of Radiation Therapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Curiel TJ; Departments of Medicine and Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, NH 03755, USA., Yu X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Integrated Immunobiology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA. Electronic address: jose.conejo-garcia@duke.edu.

Publikováno v: Immunity [Immunity] 2023 Nov 14; Vol. 56 (11), pp. 2570-2583.e6. Date of Electronic Publication: 2023 Oct 30.

Actionable spontaneous antibody responses antagonize malignant progression in ovarian carcinoma.

Autor: Handley KF; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address: Katelyn.handley@moffitt.org., Mehta S; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA., Martin AL; Department of Clinical Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; University of Tennessee Health Science Center/West Cancer Clinic, Memphis, TN 38138, USA., Biswas S; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai-410210, India., Maharaj K; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Nagy MZ; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Mine JA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Immunology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Cortina C; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Yu X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Sprenger K; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Mandal G; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Division of Cancer Biology, DBT-Institute of Life Sciences, Bhubaneswar- 751023, India., Innamarato P; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Powers JJ; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Harro CM; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Chaurio RA; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Immunology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Anadon CM; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Immunology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA., Shahzad MM; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA., Flores I; Departments of Basic Sciences and Obstetrics & Gynecology, Ponce Health Sciences University, Ponce, PR 00716, USA., Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; Department of Immunology, Duke School of Medicine, Durham, NC 27710, USA; Duke Cancer Institute, Duke School of Medicine, Durham, NC 27710, USA.

Publikováno v: Gynecologic oncology [Gynecol Oncol] 2023 Jun; Vol. 173, pp. 114-121. Date of Electronic Publication: 2023 Apr 28.

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.

Autor: Anadon CM; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Yu X; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Hänggi K; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Biswas S; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Chaurio RA; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Martin A; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Payne KK; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Mandal G; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Innamarato P; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Harro CM; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Mine JA; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Sprenger KB; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Cortina C; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Powers JJ; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Costich TL; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Perez BA; Department of Radiation Therapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Gatenbee CD; Department of Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Prabhakaran S; Department of Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Marchion D; Department of Tissue Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Heemskerk MHM; Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands., Curiel TJ; Department of Medicine, UT Health San Antonio, San Antonio, TX 78229, USA., Anderson AR; Department of Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Wenham RM; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA., Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA; Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: jose.conejo-garcia@moffitt.org.

Publikováno v: Cancer cell [Cancer Cell] 2022 May 09; Vol. 40 (5), pp. 545-557.e13. Date of Electronic Publication: 2022 Apr 14.

Two distinct mechanisms underlie estrogen-receptor-negative breast cancer susceptibility at the 2p23.2 locus.

Autor: Mendoza-Fandiño G; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Corporación Universitaria Remington, Medellin, Colombia., Lyra PCM Jr; Faculdade de Ensino e Meio Ambiente, Ariquemes, RO, Brazil., Nepomuceno TC; Instituto Nacional de Câncer, Programa de Pesquisa Clínica, Rio de Janeiro, 20231-050, Brazil., Harro CM; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, FL, USA.; Cancer Biology PhD Program, University of South Florida Tampa, Tampa, FL, 33612, USA., Woods NT; Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE, 68198, USA., Li X; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Rangel LB; Biotechnology/RENORBIO Program, Federal University of Espírito Santo, Vitória, ES, Brazil., Carvalho MA; Instituto Nacional de Câncer, Programa de Pesquisa Clínica, Rio de Janeiro, 20231-050, Brazil.; Instituto Federal do Rio de Janeiro - IFRJ, Rio de Janeiro, 20270-021, Brazil., Couch FJ; Mayo Clinic, Rochester, MN, 55905, USA., Monteiro ANA; Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. alvaro.monteiro@moffitt.org.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2022 Apr; Vol. 30 (4), pp. 465-473. Date of Electronic Publication: 2021 Nov 22.

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.

Autor: Chaurio RA; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Anadon CM; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Lee Costich T; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Payne KK; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Biswas S; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Harro CM; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Moran C; Departments of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Ortiz AC; Departments of Analytic Microscopy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Cortina C; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Rigolizzo KE; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Sprenger KB; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Mine JA; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Innamarato P; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Mandal G; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Powers JJ; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Martin A; Departments of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Wang Z; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Mehta S; Departments of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Perez BA; Departments of Radiation Therapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Li R; Departments of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Robinson J; Departments of Flow Cytometry Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Kroeger JL; Departments of Flow Cytometry Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Curiel TJ; Mays Cancer Center, University of Texas Health, San Antonio, TX 78229, USA., Yu X; Departments of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Rodriguez PC; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA., Conejo-Garcia JR; Departments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Departments of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Departments of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: jose.conejo-garcia@moffitt.org.

Publikováno v: Immunity [Immunity] 2022 Jan 11; Vol. 55 (1), pp. 115-128.e9.