Výsledky vyhledávání - "Harrison R. Troche"

Akademický článek

Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading

Autor: Meagan E. Ita, Sagar Singh, Harrison R. Troche, Rachel L. Welch, Beth A. Winkelstein

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Chronic joint pain is a major healthcare challenge with a staggering socioeconomic burden. Pain from synovial joints is mediated by the innervated collagenous capsular ligament that surrounds the joint and encodes nociceptive signals. The interstitia

Externí odkaz: https://doaj.org/article/bfdb78821310484ba39d035dc45bafd4

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Akademický článek

Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction

Autor: Meagan E. Ita, Prabesh Ghimire, Rachel L. Welch, Harrison R. Troche, Beth A. Winkelstein

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)

Abstract Degeneration is a hallmark of painful joint disease and is mediated by many proteases that degrade joint tissues, including collagenases. We hypothesized that purified bacterial collagenase would initiate nociceptive cascades in the joint by

Externí odkaz: https://doaj.org/article/344c81ec75a94e67b683c5bfb1e94eab

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Repeated High Rate Facet Capsular Stretch at Strains That are Below the Pain Threshold Induces Pain and Spinal Inflammation With Decreased Ligament Strength in the Rat

Autor: Ben A. Bulka, Sonia Kartha, Harrison R. Troche, Nicholas S. Stiansen, Beth A. Winkelstein

Publikováno v: Journal of biomechanical engineering. 140(8)

Repeated loading of ligamentous tissues during repetitive occupational and physical tasks even within physiological ranges of motion has been implicated in the development of pain and joint instability. The pathophysiological mechanisms of pain after

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6b13c630baed2cd7d5f1aa88baf3d8
https://pubmed.ncbi.nlm.nih.gov/30003250

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