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HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy.

Autor: Lee GQ; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA. gul4001@med.cornell.edu., Khadka P; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA., Gowanlock SN; Department of Microbiology and Immunology, Western University, London, ON, Canada., Copertino DC Jr; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA., Duncan MC; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Omondi FH; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Kinloch NN; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Kasule J; Rakai Health Sciences Program, Kalisizo, Uganda., Kityamuweesi T; Rakai Health Sciences Program, Kalisizo, Uganda., Buule P; Rakai Health Sciences Program, Kalisizo, Uganda., Jamiru S; Rakai Health Sciences Program, Kalisizo, Uganda., Tomusange S; Rakai Health Sciences Program, Kalisizo, Uganda., Anok A; Rakai Health Sciences Program, Kalisizo, Uganda., Chen Z; Department of Population Health Sciences, Division of Biostatistics, Weill Cornell Medicine, New York, NY, USA., Jones RB; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA., Galiwango RM; Rakai Health Sciences Program, Kalisizo, Uganda., Reynolds SJ; Rakai Health Sciences Program, Kalisizo, Uganda.; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Quinn TC; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada., Redd AD; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Prodger JL; Department of Microbiology and Immunology, Western University, London, ON, Canada.; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 02; Vol. 15 (1), pp. 5480. Date of Electronic Publication: 2024 Jul 02.

T-Cell Responses to COVID-19 Vaccines and Breakthrough Infection in People Living with HIV Receiving Antiretroviral Therapy.

Autor: Datwani S; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada., Kalikawe R; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada., Waterworth R; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada., Mwimanzi FM; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada., Liang R; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Sang Y; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada., Lapointe HR; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Cheung PK; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Omondi FH; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Duncan MC; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Barad E; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Speckmaier S; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Moran-Garcia N; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., DeMarco ML; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Hedgcock M; Spectrum Health, Vancouver, BC V6Z 2T1, Canada., Costiniuk CT; Division of Infectious Diseases Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Hull M; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Harris M; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.; Department of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Romney MG; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, BC V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Montaner JSG; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.; Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada., Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC V6A 1S6, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC V6Z 1Y6, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V6A 1S6, Canada.

Publikováno v: Viruses [Viruses] 2024 Apr 24; Vol. 16 (5). Date of Electronic Publication: 2024 Apr 24.

People With Human Immunodeficiency Virus Receiving Suppressive Antiretroviral Therapy Show Typical Antibody Durability After Dual Coronavirus Disease 2019 Vaccination and Strong Third Dose Responses.

Autor: Lapointe HR; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Mwimanzi F; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Cheung PK; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Sang Y; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Yaseen F; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Umviligihozo G; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Kalikawe R; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Speckmaier S; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Moran-Garcia N; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Datwani S; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Duncan MC; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Agafitei O; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Ennis S; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Young L; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, British Columbia, Canada., Ali H; John Ruedy Clinic, St Paul's Hospital, Vancouver, British Columbia, Canada., Ganase B; AIDS Research Program, St Paul's Hospital, Vancouver, British Columbia, Canada., Omondi FH; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Dong W; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Toy J; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Sereda P; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada., Burns L; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada., Costiniuk CT; Division of Infectious Diseases and Chronic Viral Illness Service, McGill University Health Centre and Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Cooper C; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Anis AH; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.; CIHR Canadian HIV Trials Network, University of British Columbia, Vancouver, British Columbia, Canada.; Centre for Health Evaluation and Outcome Sciences, Vancouver, British Columbia, Canada., Leung V; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Holmes DT; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., DeMarco ML; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Simons J; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Hedgcock M; Spectrum Health, Vancouver, British Columbia, Canada., Prystajecky N; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada., Lowe CF; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Pantophlet R; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Romney MG; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Barrios R; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada., Guillemi S; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Department of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Montaner JSG; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Hull M; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Harris M; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Department of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Niikura M; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada., Brockman MA; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada., Brumme ZL; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2023 Apr 12; Vol. 227 (7), pp. 838-849.

Older Adults Mount Less Durable Humoral Responses to Two Doses of COVID-19 mRNA Vaccine but Strong Initial Responses to a Third Dose.

Autor: Mwimanzi F; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Lapointe HR; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Cheung PK; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Sang Y; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Yaseen F; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Umviligihozo G; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Kalikawe R; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Datwani S; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Omondi FH; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Burns L; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada., Young L; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada., Leung V; Department of Medicine, University of British Columbia, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Agafitei O; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Ennis S; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Dong W; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Basra S; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Lim LY; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Ng K; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Pantophlet R; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada., Montaner JSG; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada., Prystajecky N; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, Canada., Lowe CF; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., DeMarco ML; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Holmes DT; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Simons J; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Niikura M; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Romney MG; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2022 Sep 21; Vol. 226 (6), pp. 983-994.