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Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection.

Autor: Swart AL; Institute of Medical Microbiology, Medical Faculty, University of Zurich, Zurich, Switzerland., Harrison CF; Max von Pettenkofer Institute, Medical Faculty, Ludwig-Maximilians University Munich, Munich, Germany., Eichinger L; Institute for Biochemistry I, Medical Faculty, University Hospital Cologne, Cologne, Germany., Steinert M; Department of Life Sciences, Institute of Microbiology, Technical University of Braunschweig, Braunschweig, Germany., Hilbi H; Institute of Medical Microbiology, Medical Faculty, University of Zurich, Zurich, Switzerland.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2018 Mar 02; Vol. 8, pp. 61. Date of Electronic Publication: 2018 Mar 02 (Print Publication: 2018).

In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA.

Autor: Slepikas L; School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.; Faculty of Pharmacy, Lithuanian University of Health Sciences , LT 44307 Kaunas, Lithuania., Chiriano G; School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Perozzo R; School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Tardy S; School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Kranjc A; School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Patthey-Vuadens O; School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Ouertatani-Sakouhi H; Department of Cell Physiology and Metabolism, CMU , Rue Michel-Servet 1 CH-1211 Geneva, Switzerland., Kicka S; Department of Biochemistry, University of Geneva , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Harrison CF; Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich , 80336 Munich, Germany., Scrignari T; Microbiology Unit, Department of Botany and Plant Biology, University of Geneva , CH-1211 Geneva, Switzerland., Perron K; Microbiology Unit, Department of Botany and Plant Biology, University of Geneva , CH-1211 Geneva, Switzerland., Hilbi H; Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich , 80336 Munich, Germany.; Institute of Medical Microbiology, Department of Medicine, University of Zürich , Gloriastrasse 30/32, CH-8006 Zürich, Switzerland., Soldati T; Department of Biochemistry, University of Geneva , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Cosson P; Department of Cell Physiology and Metabolism, CMU , Rue Michel-Servet 1 CH-1211 Geneva, Switzerland., Tarasevicius E; Faculty of Pharmacy, Lithuanian University of Health Sciences , LT 44307 Kaunas, Lithuania., Scapozza L; School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne , 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Dec 22; Vol. 59 (24), pp. 10917-10928. Date of Electronic Publication: 2016 Dec 09.

Adrenergic antagonists restrict replication of Legionella.

Autor: Harrison CF; 1​Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich, 80336 Munich, Germany., Kicka S; 2​Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland., Kranjc A; 3​School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne, 1211 Geneva, Switzerland., Finsel I; 1​Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich, 80336 Munich, Germany., Chiriano G; 3​School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne, 1211 Geneva, Switzerland., Ouertatani-Sakouhi H; 4​Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland., Soldati T; 2​Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland., Scapozza L; 3​School of Pharmaceutical Sciences, Department of Pharmaceutical Biochemistry, University of Geneva and University of Lausanne, 1211 Geneva, Switzerland., Hilbi H; 1​Max von Pettenkofer Institute, Department of Medicine, Ludwig-Maximilians University Munich, 80336 Munich, Germany 5​Institute of Medical Microbiology, Department of Medicine, University of Zurich, Gloriastrasse 30/32, 8006 Zurich, Switzerland.

Publikováno v: Microbiology (Reading, England) [Microbiology (Reading)] 2015 Jul; Vol. 161 (7), pp. 1392-406. Date of Electronic Publication: 2015 Apr 14.

Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.

Autor: Hilbi H; a Max von Pettenkofer Institute; Department of Medicine ; Ludwig-Maximilians University Munich ; Munich , Germany., Rothmeier E, Hoffmann C, Harrison CF

Publikováno v: Small GTPases [Small GTPases] 2014; Vol. 5 (3), pp. 1-6.