Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Harrison Brody, A."'
Autor:
A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-33 (2022)
Abstract Background Genetic variation at the PTK2B locus encoding the protein Pyk2 influences Alzheimer’s disease risk. Neurons express Pyk2 and the protein is required for Amyloid-β (Aβ) peptide driven deficits of synaptic function and memory in
Externí odkaz:
https://doaj.org/article/07d99d58976b4e01996ddce1ebeeb842
Akademický článek
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Autor:
A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/fd6012a0abde4da9beedc5fce7239a6d
Publikováno v:
Journal of Burn Care & Research; Mar/Apr2024, Vol. 45 Issue 2, p528-532, 5p
Autor:
Veronica Musante, Lu Li, Jean Kanyo, Tukiet T Lam, Christopher M Colangelo, Shuk Kei Cheng, A Harrison Brody, Paul Greengard, Nicolas Le Novère, Angus C Nairn
Publikováno v:
eLife, Vol 6 (2017)
ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A
Externí odkaz:
https://doaj.org/article/1c6cbe02d5e743ca833ba86d9c17d590
Autor:
Harrison Brody, A., Chou, Eunice, Gray, Janet M., Pokyrwka, Nancy J., Raley-Susman, Kathleen M.
Publikováno v:
In Neurotoxicology January 2013 34:74-81
Autor:
Joshua Spurrier, LaShae Nicholson, Xiaotian T. Fang, Austin J. Stoner, Takuya Toyonaga, Daniel Holden, Timothy R. Siegert, William Laird, Mary Alice Allnutt, Marius Chiasseu, A. Harrison Brody, Hideyuki Takahashi, Sarah Helena Nies, Azucena Pérez Cañamás, Pragalath Sadasivam, Supum Lee, Songye Li, Le Zhang, Yiyun H. Huang, Richard E. Carson, Zhengxin Cai, Stephen M. Strittmatter
Publikováno v:
Sci Transl Med
Microglia-mediated synaptic loss contributes to the development of cognitive impairments in Alzheimer’s disease (AD). However, the basis for this immune-mediated attack on synapses remains to be elucidated. Treatment with the metabotropic glutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ef758dfb90c7e993eb62d295758a33
https://doi.org/10.1126/scitranslmed.abi8593
https://doi.org/10.1126/scitranslmed.abi8593
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9ecc0a69c8efc75748625b5ccdaa20
https://doi.org/10.1002/alz.036625
https://doi.org/10.1002/alz.036625
Autor:
A. Harrison Brody, Suho Lee, Annabel S. Chyung, Santiago V. Salazar, Timothy O. Cox, Laura T. Haas, Stephen M. Strittmatter
Publikováno v:
The Journal of Neuroscience. 39:758-772
Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons. Here, we show that the risk factor Pyk2 (PTK2B) localizes specifically to neurons in adult brain. Absence of Pyk2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81909e93e1c817c8e63a4dea3c51b89
https://doi.org/10.1523/jneurosci.1873-18.2018
https://doi.org/10.1523/jneurosci.1873-18.2018
Autor:
Timothy O, Cox, Erik C, Gunther, A Harrison, Brody, Marius T, Chiasseu, Austin, Stoner, Levi M, Smith, Laura T, Haas, Jayne, Hammersley, Gareth, Rees, Bhupinder, Dosanjh, Maria, Groves, Matthew, Gardener, Claire, Dobson, Tristan, Vaughan, Iain, Chessell, Andrew, Billinton, Stephen M, Strittmatter
Publikováno v:
Annals of Clinical and Translational Neurology
Objective Amyloid‐beta oligomers (Aßo) trigger the development of Alzheimer's disease (AD) pathophysiology. Cellular prion protein (PrPC) initiates synaptic damage as a high affinity receptor for Aßo. Here, we evaluated the preclinical therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d36f7f5c180265d45d862a4329636ad4
https://pubmed.ncbi.nlm.nih.gov/30911579
https://pubmed.ncbi.nlm.nih.gov/30911579