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Akademický článek
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Akademický článek
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Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis.
Autor:
Zhou Y; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: zhou.yuebiao@gene.com., Aliagas I; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wang S; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Li CS; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Liu Z; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Bowman CM; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Burdick DJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Clark KR; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Dening TJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Flygare J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Ganti A; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Girgis HS; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hanan EJ; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Harris SF; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hu C; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Kapadia SB; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Koehler MFT; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Lai T; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Liang J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Liu X; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Ma F; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Mao J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Nicolai J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Sims J; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Unhayaker S; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wai J; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Wang X; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wu P; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Xu Y; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Yen CW; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Zhang R; Wuxi Apptec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, PR China., Elfert TF; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Tan MW; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Kofoed EM; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Crawford TD; Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: terry@gene.com.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 11, pp. 130026. Date of Electronic Publication: 2024 Nov 11.
Autor:
Peng Y; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA., Moffat JG; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., DuPai C; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Kofoed EM; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA., Skippington E; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Modrusan Z; Department of Proteomic and Genomic Technologies, Genentech Inc., South San Francisco, California, USA., Gloor SL; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Clark K; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Xu Y; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Li S; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Chen L; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Liu X; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Wu P; Department of Structural Biology, Genentech Inc., South San Francisco, California, USA., Harris SF; Department of Structural Biology, Genentech Inc., South San Francisco, California, USA., Wang S; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Crawford TD; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Li CS; WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China., Liu Z; WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China., Wai J; WuXi AppTec Co., Ltd., Waigaoqiao Free Trade Zone, Shanghai, China., Tan M-W; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.
Publikováno v:
Journal of bacteriology [J Bacteriol] 2024 Oct 24; Vol. 206 (10), pp. e0010224. Date of Electronic Publication: 2024 Sep 05.
Autor:
Kofoed EM; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA., Aliagas I; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Crawford T; Department of Medicinal Chemistry, Genentech Inc., South San Francisco, California, USA., Mao J; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Harris SF; Department of Structural Biology, Genentech Inc., South San Francisco, California, USA., Xu M; Department of Translational Immunology, Genentech Inc., South San Francisco, California, USA., Wang S; Department of Medicinal Chemistry, Genentech Inc., South San Francisco, California, USA., Wu P; Department of Structural Biology, Genentech Inc., South San Francisco, California, USA., Ma F; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Clark K; Department of Biochemistry and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Sims J; Department of Developmental Sciences Safety Assessment, Genentech Inc., South San Francisco, California, USA., Xu Y; Department of Biochemistry and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Peng Y; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA., Skippington E; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Yang Y; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Reeder J; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Ubhayakar S; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Baumgardner M; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Yan Z; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Chen J; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Park S; Department of Translational Immunology, Genentech Inc., South San Francisco, California, USA., Zhang H; Department of Translational Immunology, Genentech Inc., South San Francisco, California, USA., Yen C-W; Department of Small Molecule Pharmaceutical Science, Genentech Inc., South San Francisco, California, USA., Lorenzo M; Department of Protein Chemistry, Genentech Inc., South San Francisco, California, USA., Skelton N; Department of Discovery Chemistry, Genentech Inc., South San Francisco, California, USA., Liang X; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Chen L; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Hoag B; Department of Biochemistry and Cellular Pharmacology, Genentech Inc., South San Francisco, California, USA., Li CS; WuXi AppTec Co., Ltd., Shanghai, China., Liu Z; WuXi AppTec Co., Ltd., Shanghai, China., Wai J; WuXi AppTec Co., Ltd., Shanghai, China., Liu X; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California, USA., Liang J; Department of Medicinal Chemistry, Genentech Inc., South San Francisco, California, USA., Tan MW; Department of Infectious Diseases, Genentech Inc., South San Francisco, California, USA.
Publikováno v:
MBio [mBio] 2024 Oct 16; Vol. 15 (10), pp. e0089724. Date of Electronic Publication: 2024 Aug 29.
Autor:
Steinbach TJ; Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA., Tokarz DA; Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA., Co CA; Social & Scientific Systems, Inc., Durham, North Carolina, USA., Harris SF; Social & Scientific Systems, Inc., Durham, North Carolina, USA., McBride SJ; Social & Scientific Systems, Inc., Durham, North Carolina, USA., Shockley KR; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA., Lokhande A; AIRA Matrix, Mumbai, India., Srivastava G; AIRA Matrix, Mumbai, India., Ugalmugle R; AIRA Matrix, Mumbai, India., Kazi A; AIRA Matrix, Mumbai, India., Singletary E; Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA., Cesta MF; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA., Thomas HC; Aclairo Pharmaceutical Development Group, Vienna, Virginia, USA., Chen VS; Charles River Laboratories, Durham, North Carolina, USA.; Biogen, Cambridge, Massachusetts, USA., Hobbie K; Inotiv, Research Triangle Park, North Carolina, USA., Crabbs TA; Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA.
Publikováno v:
Toxicologic pathology [Toxicol Pathol] 2024 Jul; Vol. 52 (5), pp. 258-265. Date of Electronic Publication: 2024 Jun 22.
Autor:
Kschonsak YT; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: kschonsy@gene.com., Gao X; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: gaox7@gene.com., Miller SE; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA., Hwang S; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA., Marei H; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA., Wu P; Department of Structural Biology, Genentech Inc, South San Francisco, CA 94080, USA., Li Y; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA., Ruiz K; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA., Dorighi K; Department of Molecular Biology, Genentech Inc, South San Francisco, CA 94080, USA., Holokai L; Department of Biomarker Discovery, Genentech Inc, South San Francisco, CA 94080, USA., Perampalam P; ProCogia Inc. under contract to Hoffmann-La Roche Limited, Toronto, Ontario M5J2P1, Canada., Tsai WK; Department of Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA., Kee YS; Department of Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA., Agard NJ; Department of Antibody Engineering, Genentech Inc, South San Francisco, CA 94080, USA., Harris SF; Department of Structural Biology, Genentech Inc, South San Francisco, CA 94080, USA., Hannoush RN; Department of Early Discovery Biochemistry and Peptide Therapeutics, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: ramihannoush@gmail.com., de Sousa E Melo F; Department of Discovery Oncology, Genentech Inc, South San Francisco, CA 94080, USA. Electronic address: desousaf@gene.com.
Publikováno v:
Cell chemical biology [Cell Chem Biol] 2024 Jun 20; Vol. 31 (6), pp. 1176-1187.e10. Date of Electronic Publication: 2023 Dec 05.
Autor:
Gitlin AD; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address: gitlina@mskcc.org., Maltzman A; Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Kanno Y; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Heger K; Cancer Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Reja R; Oncology Bioinformatics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Schubert AF; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Wierciszewski LJ; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Pantua H; Infectious Diseases, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Kapadia SB; Infectious Diseases, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Harris SF; Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Webster JD; Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Newton K; Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: knewton@gene.com., Dixit VM; Physiological Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: dixit@gene.com.
Publikováno v:
Immunity [Immunity] 2024 May 14; Vol. 57 (5), pp. 973-986.e7. Date of Electronic Publication: 2024 May 01.
Autor:
Smith-Roe SL; Division of Translational Toxicology, NIEHS, Research Triangle Park, Durham, North Carolina, USA., Swartz CD; Integrated Laboratory Systems, LLC (an Inotiv company), Research Triangle Park, Durham, North Carolina, USA., Rashid A; Integrated Laboratory Systems, LLC (an Inotiv company), Research Triangle Park, Durham, North Carolina, USA., Christy NC; Integrated Laboratory Systems, LLC (an Inotiv company), Research Triangle Park, Durham, North Carolina, USA., Sly JE; Integrated Laboratory Systems, LLC (an Inotiv company), Research Triangle Park, Durham, North Carolina, USA., Chang X; Integrated Laboratory Systems, LLC (an Inotiv company), Research Triangle Park, Durham, North Carolina, USA., Sipes NS; Division of Translational Toxicology, NIEHS, Research Triangle Park, Durham, North Carolina, USA., Shockley KR; Biostatistics and Computational Biology Branch, NIEHS, Research Triangle Park, Durham, North Carolina, USA., Harris SF; Social & Scientific Systems, Inc, Durham, North Carolina, USA., McBride SJ; Social & Scientific Systems, Inc, Durham, North Carolina, USA., Larson GJ; Social & Scientific Systems, Inc, Durham, North Carolina, USA., Collins BJ; Division of Translational Toxicology, NIEHS, Research Triangle Park, Durham, North Carolina, USA., Mutlu E; Division of Translational Toxicology, NIEHS, Research Triangle Park, Durham, North Carolina, USA., Witt KL; Division of Translational Toxicology, NIEHS, Research Triangle Park, Durham, North Carolina, USA.
Publikováno v:
Environmental and molecular mutagenesis [Environ Mol Mutagen] 2023 Apr; Vol. 64 (4), pp. 202-233. Date of Electronic Publication: 2023 Mar 07.