Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer

Autor: C Qi, Dionisios Stavroulias, J L Derham, Michael Skwarski, E Belcher, Joshua A. Bull, P Ferencz, Chu K-Y., Fergus V. Gleeson, Daniel P. Bulte, Paula L. Croal, Francesca M. Buffa, Adrian L. Harris, O’Connor Jpb., Marcus Green, Harris Bhl., H Flight, Leticia Campo, D O’Reilly, J Chauhan, Jane Holmes, Mark McCole, Geoff S. Higgins, Gonzalo Rodriguez-Berriguete, F Di Chiara, W G McKenna, Eugene Teoh, Lisa K. Folkes, Ruth MacPherson, Daniel R. McGowan, Philip S. Macklin, Remko Prevo

Publikováno v: Clin Cancer Res

Purpose: Tumor hypoxia fuels an aggressive tumor phenotype and confers resistance to anticancer treatments. We conducted a clinical trial to determine whether the antimalarial drug atovaquone, a known mitochondrial inhibitor, reduces hypoxia in non�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacc9a0024cedfd7332836a2f33e4c90
https://pubmed.ncbi.nlm.nih.gov/33597271

Twelve tips for designing and implementing peer-led assessment writing schemes in health professions education.

Autor: Harris BHL; Department of Oncology, University of Oxford, Oxford, United Kingdom., Harris SRL; Department of Oncology, University of Oxford, Oxford, United Kingdom., Walsh JL; Department of Cardiology, Royal Brompton and Harefield Hospitals NHS Trust, London, United Kingdom.; Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Pereira C; Cutrale Perioperative and Ageing Group, Department of Bioengineering, Imperial College London, London, United Kingdom., Black SM; Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Allott VES; Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Handa A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom., Thampy H; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Publikováno v: Medical teacher [Med Teach] 2024 Aug; Vol. 46 (8), pp. 1027-1034. Date of Electronic Publication: 2024 Jan 26.

Diversity of thought: public perceptions of genetic testing across ethnic groups in the UK.

Autor: Harris BHL; Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.; St Anne's College, 56 Woodstock Rd, Oxford, OX2 6HS, UK., McCabe C; St Anne's College, 56 Woodstock Rd, Oxford, OX2 6HS, UK., Shafique H; Duke University School of Medicine, Durham, NC, 27710, USA., Lammy S; Department of Neurosurgery, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, G51 4TF, UK., Tookman L; Hammersmith Hospital, Imperial College Healthcare NHS trust, London, W12 0HS, UK., Flanagan J; Department of Surgery and Cancer, Imperial College London, Du Cane Road, London, W12 0HS, UK., Miron-Barroso S; Department of Surgery and Cancer, Imperial College London, Du Cane Road, London, W12 0HS, UK., Lythgoe M; Department of Surgery and Cancer, Imperial College London, Du Cane Road, London, W12 0HS, UK., Clark J; Department of Surgery and Cancer, Imperial College London, Du Cane Road, London, W12 0HS, UK., Walsh JL; Hammersmith Hospital, Imperial College Healthcare NHS trust, London, W12 0HS, UK., Di Giovannantonio M; Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Krell J; Department of Surgery and Cancer, Imperial College London, Du Cane Road, London, W12 0HS, UK. j.krell@imperial.ac.uk.

Publikováno v: Journal of human genetics [J Hum Genet] 2024 Jan; Vol. 69 (1), pp. 19-25. Date of Electronic Publication: 2023 Nov 01.

Obesity: a perfect storm for carcinogenesis.

Autor: Harris BHL; Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK. benjamin.harris@oncology.ox.ac.uk.; St Anne's College, 56 Woodstock Rd, Oxford, OX2 6HS, UK. benjamin.harris@oncology.ox.ac.uk., Macaulay VM; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, OX3 9DU, UK., Harris DA; St Anne's College, 56 Woodstock Rd, Oxford, OX2 6HS, UK., Klenerman P; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, OX1 3SY, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK., Lord SR; Early Phase Clinical Trials Unit, Churchill Hospital, Oxford, OX3 7LE, UK., Harris AL; Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Buffa FM; Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK. francesca.buffa@oncology.ox.ac.uk.

Publikováno v: Cancer metastasis reviews [Cancer Metastasis Rev] 2022 Sep; Vol. 41 (3), pp. 491-515. Date of Electronic Publication: 2022 Aug 30.

Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility.

Autor: Rosadas C; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Khan M; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Parker E; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Marchesin F; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Katsanovskaja K; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Sureda-Vives M; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Fernandez N; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Randell P; Department of Infection and Immunity, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, W6 8RF, UK., Harvey R; Worldwide Influenza Centre, Francis Crick Institute, London, NW1 1AT, UK., Lilley A; Worldwide Influenza Centre, Francis Crick Institute, London, NW1 1AT, UK., Harris BHL; The Wellington Hospital, Circus Road, St John's Wood, London, NW8 6PD, UK; Computational Biology and Integrative Genomics, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK., Zuhair M; The Wellington Hospital, Circus Road, St John's Wood, London, NW8 6PD, UK., Fertleman M; The Wellington Hospital, Circus Road, St John's Wood, London, NW8 6PD, UK., Ijaz S; Blood Borne Virus Unit, National Infection Service, Colindale Public Health England, London, NW9 5EQ, UK., Dicks S; Blood Borne Virus Unit, National Infection Service, Colindale Public Health England, London, NW9 5EQ, UK; Transfusion Microbiology, NHS Blood and Transplant, Lingard Avenue, London, NW9 5BG, UK., Short CE; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Quinlan R; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Taylor GP; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Hu K; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., McKay P; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Rosa A; Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, NW1 1AT, UK; Crick COVID19 Consortium, Francis Crick Institute, London, NW1 1AT, UK., Roustan C; Structural Biology Science Technology Platform, Francis Crick Institute, London, NW1 1AT, UK; Crick COVID19 Consortium, Francis Crick Institute, London, NW1 1AT, UK., Zuckerman M; Department of Virology, King's College Hospital, London, SE5 9RS, UK., El Bouzidi K; Department of Virology, King's College Hospital, London, SE5 9RS, UK., Cooke G; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Flower B; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Moshe M; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Spencer AJ; Jenner Institute, University of Oxford, ORCRB, Oxford, OX3 7DQ, UK., Lambe T; Jenner Institute, University of Oxford, ORCRB, Oxford, OX3 7DQ, UK., Gilbert SC; Jenner Institute, University of Oxford, ORCRB, Oxford, OX3 7DQ, UK., Kingston H; Department of Infection and Immunity, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, W6 8RF, UK., Baillie JK; Roslin Institute, University of Edinburgh, Midlothian, EH25 9RG, UK., Openshaw PJM; National Heart and Lung Institute, Imperial College London, Chelsea, London, SW3 6LY, UK., Semple MG; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7BE, UK., Cherepanov P; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK; Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, NW1 1AT, UK; Crick COVID19 Consortium, Francis Crick Institute, London, NW1 1AT, UK., McClure MO; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Tedder RS; Department of Infectious Disease, Imperial College London, St Mary's Campus, London, W2 1PG, UK. Electronic address: r.tedder@imperial.ac.uk.

Publikováno v: Journal of virological methods [J Virol Methods] 2022 Apr; Vol. 302, pp. 114475. Date of Electronic Publication: 2022 Jan 22.