Výsledky vyhledávání - "Harris Goldstein"

Akademický článek

Interventions during Early Infection: Opening a Window for an HIV Cure?

Autor: Christopher R. Hiner, April L. Mueller, Hang Su, Harris Goldstein

Publikováno v: Viruses, Vol 16, Iss 10, p 1588 (2024)

Although combination antiretroviral therapy (ART) has been a landmark achievement for the treatment of human immunodeficiency virus (HIV), an HIV cure has remained elusive. Elimination of latent HIV reservoirs that persist throughout HIV infection is

Externí odkaz: https://doaj.org/article/de68b5a0fb304d55bc9aea030444186b

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Akademický článek

In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells

Publikováno v: JCI Insight, Vol 7, Iss 21 (2022)

HIV-specific chimeric antigen receptor–T cell (CAR T cell) therapies are candidates to functionally cure HIV infection in people with HIV (PWH) by eliminating reactivated HIV-infected cells derived from latently infected cells within the HIV reserv

Externí odkaz: https://doaj.org/article/07c21215b58f4bf69b7d186bb38fd62e

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Akademický článek

HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

The intact proviral DNA assay quantifies the genomically intact HIV reservoir, but assay failure due to HIV-1 polymorphism has been observed. Here, the authors report a 28% failure rate in a cohort of people with HIV-1, and note within-host HIV-1 div

Externí odkaz: https://doaj.org/article/2f1b4a3b13f745078fbaecf15223c1ef

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Akademický článek

Engineered Antigen-Specific T Cells Secreting Broadly Neutralizing Antibodies: Combining Innate and Adaptive Immune Response against HIV

Autor: Allison B. Powell, Yanqin Ren, Maria Korom, Devin Saunders, Patrick J. Hanley, Harris Goldstein, Douglas F. Nixon, Catherine M. Bollard, Rebecca M. Lynch, R. Brad Jones, Conrad Russell Y. Cruz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 78-88 (2020)

While antiretroviral therapy (ART) can completely suppress viremia, it is not a cure for HIV. HIV persists as a latent reservoir of infected cells, able to evade host immunity and re-seed infection following cessation of ART. Two promising immunother

Externí odkaz: https://doaj.org/article/f8e6ea291a00474abdba97036edada0b

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Self-Reported Use of HIV Preexposure Prophylaxis Is Highly Accurate Among Sexual Health Clinic Patients in New York City

Autor: Saba Qasmieh, Denis Nash, Monica Gandhi, Elliot Rozen, Hideaki Okochi, Harris Goldstein, Betsy C. Herold, Kelly Jamison, Preeti Pathela

Publikováno v: Sexually transmitted diseases. 49(11)

In New York City, 91% of sexually transmitted infection clinic patients reported preexposure prophylaxis (PrEP) use that matched the detection of PrEP in their serum. Self-report had 80% sensitivity and 96% specificity ( κ = 0.79) compared with meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a428fb47b509456a53c9b05bcd89d77a
https://pubmed.ncbi.nlm.nih.gov/35312670

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