Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Harriet W. Hamilton"'
Autor:
Elizabeth A. Lunney, Frederick E. Boyer, J. V. N. Vara Prasad, Stephen J. Gracheck, Carolyn Nouhan, Edmund L. Ellsworth, Bradley Dean Tait, Donna Ferguson, Susan Elizabeth Hagen, Steven VanderRoest, Larry J. Markoski, James Saunders, Harriet W. Hamilton, B. A. Steinbaugh, Peter J. Tummino, John M. Domagala, Donald Hupe, Christopher Gajda
Publikováno v:
Journal of Medicinal Chemistry. 40:3707-3711
Autor:
John W. Erickson, Donald Hupe, Eric T. Baldwin, J. R. Rubin, and Sergei V. Gulnik, Christine Humblet, Susan Elizabeth Hagen, Christopher Gajda, Harriet W. Hamilton, Carolyn Nouhan, Beishan Liu, J. V. N. Vara Prasad, Neil Graham, Edmund L. Ellsworth, Peter J. Tummino, John M. Domagala, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney, T. N. Bhat, Bradley Dean Tait, Stephen J. Gracheck
Publikováno v:
Journal of Medicinal Chemistry. 40:3781-3792
The 4-hydroxy-5,6-dihydropyrone template was utilized as a flexible scaffolding from which to build potent active site inhibitors of HIV protease. Dihydropyrone 1c (5,6-dihydro-4-hydroxy-6-phenyl-3-[(2-phenylethyl)thio]-2H-pyran-2-one) was modeled in
Autor:
Peter J. Tummino, Donna Ferguson, B. A. Steinbaugh, Kimberly Suzanne Para, Harriet W. Hamilton, J. V. N. Vara Prasad, Elizabeth A. Lunney, C. John Blankley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1099-1104
In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of
Autor:
Christopher Gajda, Bradley Dean Tait, Peter J. Tummino, Harriet W. Hamilton, Susan Elizabeth Hagen, Alexander Pavlovsky, Donna Ferguson, Elizabeth A. Lunney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:719-724
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones1 as HIV protease inhibitors. The current work examines the analogous 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the us
Autor:
Elizabeth A. Lunney, A M Doherty, B. A. Steinbaugh, James Stanley Kaltenbronn, Aurash Shahripour, Mark Stephen Plummer, James Marino Hamby, Tomi K. Sawyer, Christine Humblet, Harriet W. Hamilton
Publikováno v:
Journal of Medicinal Chemistry. 38:2893-2905
A series of renin inhibitors were designed to examine the topography of the contiguous binding pocket of renin that is normally occupied by the P1 and P3 side chains. Molecular modeling suggested that extending the P1 hydrophobic side chain into the
Autor:
E L Reyner, Harriet W. Hamilton, H L Schmid, M. D. Taylor, B. A. Steinbaugh, R H Lu, O H Chan, Barbra H. Stewart
Publikováno v:
Pharmaceutical Research. 12:693-699
In vitro and in situ experimental models that are descriptive of drug absorption in vivo are valuable tools in the discovery of new chemical entities that are bioavailable after oral administration. The specific objective of the study was to compare
Autor:
Takeshi Nakamura, Wataru Watanabe, Hidetsura Cho, Eric C Nordby, Peter Craig Weber, Harriet W. Hamilton, Susan Elizabeth Hagen, Stefanie L Boulware, Gisele Nishiguchi, Stephen J. Gracheck, John D Domagala, Satoru Ikeda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2981-2983
A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the
Autor:
B. A. Steinbaugh, Barbra H. Stewart, M. D. Taylor, J. Blankley, O H Chan, R. Schroeder, J. Cook, C. Stewart, Harriet W. Hamilton, Stephen T. Rapundalo, Michael J. Ryan, A. Bernabei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:813-818
Three structurally similar peptidomimetic analogs with varying logP's and molecular weights were evaluated in the in situ rat gut perfusion assay and isolated perfused rat liver to analyze their absorption and clearance characteristics.
Autor:
James A. Bristol, S. A. Johnson, W. J. Kramer, Bharat K. Trivedi, Michael J. Ryan, William C. Patt, Harriet W. Hamilton, D. M. Cohen, C. J. Blankley, Robert F. Bruns
Publikováno v:
ChemInform. 22
Adenosine is known to exert a wide range of pharmacological effects including hypotension. This effect of adenosine suggested that modified analogues of adenosine might provide useful antihypertensive agents. Thus, we prepared a series of novel N6-be
Autor:
D. G. Jun. Taylor, M. D. Taylor, C. A. Painchaud, Brian L. Batley, Michael J. Ryan, Stephen T. Rapundalo, Connolly Cleo, Harriet W. Hamilton, William C. Patt
Publikováno v:
ChemInform. 23