Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harriet R. Ferguson"'
Autor:
Weronika E. Borek, Luis Nobre, S. Federico Pedicona, Amy E. Campbell, Josie A. Christopher, Nazrath Nawaz, David N. Perkins, Pedro Moreno-Cardoso, Janet Kelsall, Harriet R. Ferguson, Bela Patel, Paolo Gallipoli, Andrea Arruda, Alex J. Ambinder, Andrew Thompson, Andrew Williamson, Gabriel Ghiaur, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas, Arran D. Dokal
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105316- (2024)
Summary: Background: Acute myeloid leukaemia (AML) is a bone marrow malignancy with poor prognosis. One of several treatments for AML is midostaurin combined with intensive chemotherapy (MIC), currently approved for FLT3 mutation-positive (FLT3-MP) A
Externí odkaz:
https://doaj.org/article/c1ed1c39383540cb899802e9a5af0c25
Autor:
Joanne Watson, Harriet R. Ferguson, Rosie M. Brady, Jennifer Ferguson, Paul Fullwood, Hanyi Mo, Katherine H. Bexley, David Knight, Gareth Howell, Jean-Marc Schwartz, Michael P. Smith, Chiara Francavilla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Recruitment of Receptor Tyrosine Kinase signalling partners during endocytosis, specifically during recycling to the plasma membrane, is crucial to signal propagation and regulation. Here, the authors reveal FGFR signalling partners proximal to recyc
Externí odkaz:
https://doaj.org/article/7ca1d246354d484086dace8d1d9fc7b7
Autor:
Arran Dokal, Weronika E. Borek, Luis Nobre, Salvatore Federico Pedicona, Bela Wrench, Paolo Gallipoli, Andrea Arruda, Amy E. Campbell, Nazrath Nawaz, Harriet R. Ferguson, David N. Perkins, Pedro Moreno-Cardoso, Andrew Thompson, Andrew J.K. Williamson, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas
Publikováno v:
HemaSphere, Vol 7, p e3920765 (2023)
Externí odkaz:
https://doaj.org/article/9587d3fdbfdb464ab33fdd2f65eb362d
Publikováno v:
Cells, Vol 10, Iss 5, p 1201 (2021)
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor. The Fibroblast Growth Factor (FG
Externí odkaz:
https://doaj.org/article/d2cda442a4804ac0a8849a696332b2d3
Autor:
Joanne Watson, Harriet R. Ferguson, Rosie M. Brady, Jennifer Ferguson, Paul Fullwood, Hanyi Mo, Katherine H. Bexley, David Knight, Jean-Marc Schwartz, Michael P. Smith, Chiara Francavilla
SummaryReceptor Tyrosine Kinase (RTK) endocytosis-dependent signalling drives cell proliferation and motility during development and adult homeostasis, but is dysregulated in diseases, including cancer. The recruitment of RTK signalling partners duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1cf6881c69de1535d96a6846a857889
https://doi.org/10.1101/2021.12.04.471203
https://doi.org/10.1101/2021.12.04.471203
Publikováno v:
Cells, Vol 10, Iss 1201, p 1201 (2021)
Cells
Cells
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor. The Fibroblast Growth Factor (FG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86c43583cfdecb8785b43a232bcb1d5
https://www.mdpi.com/2073-4409/10/5/1201
https://www.mdpi.com/2073-4409/10/5/1201
Autor:
Christian Bates, Paul Fullwood, Chiara Francavilla, Joseph Parsons, Harriet R. Ferguson, Thomas Kedward, David Knight, Stacey Warwood, Robert Clarke, Michael P. Smith, Katarzyna M. Kowalczyk, Egor Zindy, Joanne Watson, Sarah Chandler, Jennifer Ferguson
Publikováno v:
Smith, M, Ferguson, H, Ferguson, J, Zindy, E, Kowalczyk, K, Kedward, T, Bates, C, Parsons, J, Watson, J, Chandler, S, Fullwood, P, Warwood, S, Clarke, R & Francavilla, C 2021, ' Reciprocal Priming between Receptor Tyrosine Kinases at Recycling Endosomes Orchestrates Cellular Signalling Outputs ', EMBO Journal, vol. 40, no. 14, e107182, pp. e107182 . https://doi.org/10.15252/embj.2020107182
Integration of signalling downstream of individual receptor tyrosine kinases (RTKs) is crucial to fine-tune cellular homeostasis during development and in pathological conditions, including breast cancer. However, how signalling integration is regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1372f5394a70fc1a4186ac72e5fb4ce3
https://doi.org/10.15252/embj.2020107182
https://doi.org/10.15252/embj.2020107182
Autor:
Chiara Francavilla, Paul Fullwood, Harriet R. Ferguson, Thomas Kedward, Joseph Parsons, Katarzyna M. Kowalczyk, Michael P. Smith, Robert Clarke, Sarah Chandler, Christian Bates, Jennifer Ferguson, David Knight, Egor Zindy, Stacey Warwood, Joanne Watson
SUMMARYIntegration of signalling downstream of individual receptor tyrosine kinases (RTKs) is crucial to fine tune cellular homeostasis during development and in pathological conditions, including breast cancer. However, how signalling integration is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c3bc06365576ff9264e93ceb7145f11
https://doi.org/10.1101/2021.01.04.425243
https://doi.org/10.1101/2021.01.04.425243
Autor:
Helen J. Cooper, Katie Brookes, Andrew J. Creese, Harriet R. Ferguson, Hongyan Zhao, John K. Heath, Katherine P. B. Larkins, Anna A. Marusiak, Debbie L. Cunningham, Adil R. Sarhan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Fibroblast Growth Factor (FGF) dependent signalling is frequently activated in cancer by a variety of different mechanisms. However, the downstream signal transduction pathways involved are poorly characterised. Here a quantitative differential phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747c65f57140163ab2b08b9b528cd3d0
https://pubmed.ncbi.nlm.nih.gov/32409632
https://pubmed.ncbi.nlm.nih.gov/32409632