Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Harriet M. Loovers"'
Autor:
Harold J. G. M. van Megen, Eibert R. Heerdink, Jan van der Weide, Toine C. G. Egberts, Jochem G. Gregoor, Harriet M. Loovers
Publikováno v:
Psychiatric Genetics. 20:311-316
Background Treatment with atypical antipsychotic agents is often complicated by dyslipidemia, which is a risk factor for cardiovascular disease. Objectives To determine whether the LEPR Q223R, the LEP -2548G/A, and the HTR2C -759C/T polymorphisms are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bddb0637b3bb8d6df5438ecf8b0389b
https://doi.org/10.1097/ypg.0b013e32833b6378
https://doi.org/10.1097/ypg.0b013e32833b6378
Publikováno v:
The Pharmacogenomics Journal. 11:359-367
Polymorphisms in genes coding for drug metabolizing enzymes, such as the cytochrome P450 enzymes CYP2C19 and CYP2D6, can lead to therapy failure and side effects. In earlier studies, the novel variant CYP2C19*17 increased metabolism of several CYP2C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c5c996aaba9ae3a1d4ed3d7ed8359a
https://doi.org/10.1038/tpj.2010.39
https://doi.org/10.1038/tpj.2010.39
Publikováno v:
European Journal of Clinical Pharmacology. 64:979-986
Genetic polymorphisms in cytochrome P450 (CYP) enzyme CYP2D6 have a substantial effect on the success of pharmacotherapy. Different models, including a predicted-phenotype model and a semi-quantitative gene dose (SGD) model, have been developed based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a1c741963c75c8cbdba019aca342b5
https://doi.org/10.1007/s00228-008-0509-3
https://doi.org/10.1007/s00228-008-0509-3
Autor:
K. van der Weide, T. van der Straaten, Kirsten M. Pondman, Jan P.A.M. Bogers, Jan N. M. Commandeur, J. van der Weide, Harriet M. Loovers, Dan Cohen, Ellen Langemeijer
Publikováno v:
Pharmacogenomics Journal, 17(5), 471-478
Pharmacogenomics Journal. Nature Publishing Group
Van der Weide, K, Loovers, H, Pondman, K, Bogers, J, van der Straaten, T, Langemeijer, E V, Cohen, D, Commandeur, J N M & van der Weide, J 2016, ' Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population. ', Pharmacogenomics Journal . https://doi.org/10.1038/tpj.2016.32
Pharmacogenomics Journal. Nature Publishing Group
Van der Weide, K, Loovers, H, Pondman, K, Bogers, J, van der Straaten, T, Langemeijer, E V, Cohen, D, Commandeur, J N M & van der Weide, J 2016, ' Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population. ', Pharmacogenomics Journal . https://doi.org/10.1038/tpj.2016.32
Prescription of clozapine is complicated by the occurrence of clozapine-induced reduction of neutrophils. The aim of this study was to identify genetic risk factors in a population of 310 Dutch patients treated with clozapine, including 38 patients d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd73a3d74ff8bd8df5702c632325dac
https://pubmed.ncbi.nlm.nih.gov/27168101
https://pubmed.ncbi.nlm.nih.gov/27168101
Autor:
Jochem G. Gregoor, Harriet M. Loovers, Jan van der Weide, Toine C. G. Egberts, Eibert R. Heerdink, Harold J. G. M. van Megen
Publikováno v:
Pharmacogenomics. 12(6)
Weight gain is a frequently occurring serious somatic adverse effect of atypical antipsychotic agents. Genetic factors influence the risk of an individual to gain weight. Objectives: To determine whether LEPR Q223R, LEP -2548G/A and HTR2C -759C/T pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9c503bcf90a3f8b8d232339b204751
https://pubmed.ncbi.nlm.nih.gov/21510767
https://pubmed.ncbi.nlm.nih.gov/21510767
Autor:
Jan van der Weide, Harriet M. Loovers
Publikováno v:
Expert opinion on drug metabolismtoxicology. 5(9)
Response to pharmacotherapy is subject to large inter-individual variation. Most medicine is metabolised by CYP450 enzymes, including CYP2D6. CYP2D6 activity is determined substantially by the genetic composition. Polymorphisms of CYP2D6 are associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216305feb16ebf990fffb9f9ff3b34e9
https://pubmed.ncbi.nlm.nih.gov/19572825
https://pubmed.ncbi.nlm.nih.gov/19572825