Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Harriet Kruszyna"'
Publikováno v:
Inorganic Chemistry. 44:2964-2972
Colorimetric (near-UV absorption spectroscopy) and calorimetric (isothermal titration calorimetry) methods have been used to quantify the equilibrium and thermodynamics of arsenite and monomethylarsenite (MMA) coordinating to glutathione (GSH) and th
Autor:
Gary M. Joffe, Kirk P. Conrad, Roger P. Smith, Monique D. Mosher, Harriet Kruszyna, Lori G. Rochelle, Jose E. Chavez, Robert Kruszyna
Publikováno v:
The FASEB Journal. 7:566-571
We reported previously that plasma levels, urinary excretion, and metabolic production of cyclic guanosine 3',5'-monophosphate (cGMP) are increased in gravid rats, and postulated that endogenous nitric oxide (NO), a potent vasodilator and immune modu
Publikováno v:
Fundamental and Applied Toxicology. 17:120-127
Sodium azide is a chemical of rapidly growing commercial importance with a high acute toxicity and an unknown mechanism of action. Although it has some chemical properties and biological effects in common with cyanide, its lethality does not appear t
Autor:
Joyce A. DeLeo, Roger P. Smith, Dean E. Wilcox, Qizhi Wang, Judith M. Jacobs, Robert Kruszyna, Harriet Kruszyna
Publikováno v:
Life Sciences. 49:PL55-PL60
Mice given ip bacterial endotoxin (LPS) at 10 mg/kg showed a statistically significant decrease in plasma glucose and an increase in hematocrit at 2 h after injection. Glucose was still decreased at 4 h, but the hematocrit had returned to control val
Publikováno v:
Toxicological Sciences. 17:120-127
Autor:
Roger P. Smith, Vergil H. Ferm, Dean E. Wilcox, Harriet Kruszyna, Theodore R. Sana, Robert Kruszyna
Publikováno v:
Fundamental and Applied Toxicology. 15:754-759
Pairs of osmotic minipumps containing 400 mg/ml (6.15 m ) sodium azide in distilled water were subcutaneously implanted in timed pregnancy Syrian golden hamsters. The total delivered dose was calculated as 6 × 10 −2 mmol kg −1 hr −1 at the max
Autor:
THEODORE R. SANA, VERGIL H. FERM, ROGER P. SMITH, ROBERT KRUSZYNA, HARRIET KRUSZYNA, DEAN E. WILCOX
Publikováno v:
Toxicological Sciences. 15:754-759
Autor:
Roger P. Smith, Harriet Kruszyna, Lori G. Rochelle, Aaron Barchowsky, Robert Kruszyna, Dean E. Wilcox
Publikováno v:
Toxicology and applied pharmacology. 128(1)
Sodium nitroprusside (Na 2 [(CN) 5 FeNO], SNP), which is stable, diamagnetic, and not detectable by electron paramagnetic resonance (EPR) spectroscopy, can be activated by one-electron reduction. The initial product, which retains the five cyanides a
Publikováno v:
Toxicology. 88(1-3)
N-Morpholino-N-nitrosoaminoacetonitrile (SIN-1), a nitrovasodilator metabolite of the drug, molsidomine, is widely used in studies on the pharmacology and toxicology of nitric oxide (NO) because solutions of SIN-1 'spontaneously' release NO in a path