Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harriet Bennett-Lenane"'
Autor:
Eman Mohamed Elmokadem, Azza A. Mahmoud, Harriet Bennett-Lenane, Kevin D. Murphy, Noha Khalil
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-9 (2024)
Abstract Objective This study examined the impact of a short-term study abroad program, focusing on program evaluation, attendee satisfaction, and acquired knowledge and skills. A questionnaire survey was conducted covering various aspects including
Externí odkaz:
https://doaj.org/article/9c0db5213afd47aa8ed18dedbc8b8041
Autor:
Harriet Bennett-Lenane, Joseph P. O’Shea, Jack D. Murray, Alexandra-Roxana Ilie, René Holm, Martin Kuentz, Brendan T. Griffin
Publikováno v:
Pharmaceutics, Vol 13, Iss 9, p 1398 (2021)
In response to the increasing application of machine learning (ML) across many facets of pharmaceutical development, this pilot study investigated if ML, using artificial neural networks (ANNs), could predict the apparent degree of supersaturation (a
Externí odkaz:
https://doaj.org/article/7b06bc13a1894a9ba8b0eaab5f9147a4
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 168
Despite countless advances in recent decades across various in vitro, in vivo and in silico tools, anticipation of whether a drug will show a human food effect (FE) remains challenging. One means to predict potential FE involves probing any dependenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03112d2c6ad36e2e288b38ea8af0f01a
https://pubmed.ncbi.nlm.nih.gov/34563654
https://pubmed.ncbi.nlm.nih.gov/34563654
Autor:
Martin Kuentz, Niklas J. Koehl, Daniel J. Price, René Holm, Laura J. Henze, Harriet Bennett-Lenane, Waleed Faisal, Brendan T. Griffin
Publikováno v:
Koehl, N J, Henze, L J, Bennett-Lenane, H, Faisal, W, Price, D J, Holm, R, Kuentz, M & Griffin, B T 2021, ' In Silico, in Vitro, and in Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax ', Molecular Pharmaceutics, vol. 18, no. 6, pp. 2174-2188 . https://doi.org/10.1021/acs.molpharmaceut.0c00645
Molecular Pharmaceutics
Molecular Pharmaceutics
The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in silico-in vitro-in vivo approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2776c425b60b01e7e53c4192e741d5b
https://findresearcher.sdu.dk:8443/ws/files/183357915/acs.molpharmaceut.0c00645.pdf
https://findresearcher.sdu.dk:8443/ws/files/183357915/acs.molpharmaceut.0c00645.pdf
Autor:
Laura J. Henze, Joseph P. O'Shea, Jacob Rune Jørgensen, Niklas J. Koehl, Harriet Bennett-Lenane, Anette Müllertz, Brendan T. Griffin
Publikováno v:
Bennett-Lenane, H, Jørgensen, J R, Koehl, N J, Henze, L J, O'Shea, J P, Müllertz, A & Griffin, B T 2021, ' Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates : Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools ', European Journal of Pharmaceutical Sciences, vol. 161, 105778 . https://doi.org/10.1016/j.ejps.2021.105778
Validation and characterisation of in vitro and pre-clinical animal models to support bio-enabling formulation development is of paramount importance. In this work, post-mortem gastric and small intestinal fluids were collected in the fasted, fed sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fb52694411d08daffa803bad79c3bc
https://curis.ku.dk/ws/files/263034089/1_s2.0_S0928098721000804_main.pdf
https://curis.ku.dk/ws/files/263034089/1_s2.0_S0928098721000804_main.pdf
Autor:
Laura J. Henze, René Holm, Harriet Bennett-Lenane, Brendan T. Griffin, Werner Weitschies, Felix Schneider, Mirko Koziolek, Niklas J. Koehl, Michael Grimm
Publikováno v:
European Journal of Pharmaceutical Sciences
Within preclinical research, the pig has become an important model in regulatory toxicology and pharmacokinetics, to assess oral dosage forms and to compare different formulation strategies. In addition, there are emerging application of the pig mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6482651290bdf7248d4f9ab842919c46
https://hdl.handle.net/10468/11443
https://hdl.handle.net/10468/11443
Autor:
Patrick J, O'Dwyer, Karl J, Box, Niklas J, Koehl, Harriet, Bennett-Lenane, Christos, Reppas, Rene, Holm, Martin, Kuentz, Brendan T, Griffin
Publikováno v:
Molecular pharmaceutics. 17(9)
The absence of an intestinal absorption sink is a significant weakness of standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8453dee903d030d02f453f36e06421fd
https://pubmed.ncbi.nlm.nih.gov/32787274
https://pubmed.ncbi.nlm.nih.gov/32787274
Autor:
Joseph P. O'Shea, Niklas J. Koehl, Harriet Bennett-Lenane, Karl J. Box, Patrick J O'Dwyer, Brendan T. Griffin
Publikováno v:
Journal of pharmaceutical sciences. 110(1)
Computational approaches are increasingly utilised in development of bio-enabling formulations, including self-emulsifying drug delivery systems (SEDDS), facilitating early indicators of success. This study investigated if in silico predictions of dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d92dad9e59dd66159aabfa447241c8
https://pubmed.ncbi.nlm.nih.gov/33144233
https://pubmed.ncbi.nlm.nih.gov/33144233
Publikováno v:
Journal of pharmaceutical sciences. 109(11)
Increasing numbers of poorly water soluble drugs in development has intensified need for bio-enabling formulations including Lipid-Based Formulations (LBF) and Solid Dispersions (SD). Resultantly, a data-driven approach is required to increase formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefe5c6817789104437bf3c4506cd823
https://pubmed.ncbi.nlm.nih.gov/32822721
https://pubmed.ncbi.nlm.nih.gov/32822721