Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Harriet Andersén"'
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Effects of genetic deletion of soluble 5′-nucleotidases NT5C1A and NT5C2 on AMPK activation and nucleotide levels in contracting mouse skeletal muscles
Autor: Mohammad Bohlooly-Y, Samanta Kviklyte, Mark H. Rider, Xiufeng Xu, Philippe Gailly, Jan Oscarsson, Harriet Andersén, Didier Vertommen, Xavier Yerna
Publikováno v: Amerian Journal of Physiology : Endocrinology and Metabolism (Online), Vol. 313, no. 1, p. E48-E62 (2017)
AMP-activated protein kinase (AMPK) plays a key role in energy homeostasis and is activated in response to contraction-induced ATP depletion in skeletal muscle via a rise in intracellular AMP/ADP concentrations. AMP can be deaminated by AMP-deaminase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc3f654bbb917e2a335630513e15578
https://doi.org/10.1152/ajpendo.00304.2016
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3
Genetic deletion of soluble 5'-nucleotidase II reduces body weight gain and insulin resistance induced by a high-fat diet
Autor: Manuel Johanns, Harriet Andersén, Olivier Schakman, Samanta Kviklyte, Caroline Bouzin, Katrien Corbeels, Mohammad Bohlooly-Y, Mark H. Rider, Didier Vertommen, Patrice D. Cani, Thibaut Duparc, Sheng-Ju Chuang, Roxane Jacobs, Bart Van der Schueren, Gaëtan Herinckx, Jan Oscarsson
Publikováno v: Molecular genetics and metabolism. 126(4)
We previously investigated whether inhibition of AMP-metabolizing enzymes could enhance AMP-activated protein kinase (AMPK) activation in skeletal muscle for the treatment of type 2 diabetes. Soluble 5'-nucleotidase II (NT5C2) hydrolyzes IMP and its
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af8836d3efa1419bf7ea836431ea18d
https://pubmed.ncbi.nlm.nih.gov/30803894
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4
Effects of Pharmacological AMP Deaminase Inhibition and Ampd1 Deletion on Nucleotide Levels and AMPK Activation in Contracting Skeletal Muscle
Autor: Louis Hue, Nadège Zanou, Mark H. Rider, Samanta Kviklyte, Lars Löfgren, Catheline Plaideau, Philippe Gailly, Yu-Chiang Lai, Didier Vertommen, Mohammad Bohlooly-Y, Harriet Andersén, Stefan Hallén
Publikováno v: Chemistry & Biology. 21(11):1497-1510
SummaryAMP-activated protein kinase (AMPK) plays a central role in regulating metabolism and energy homeostasis. It achieves its function by sensing fluctuations in the AMP:ATP ratio. AMP deaminase (AMPD) converts AMP into IMP, and the AMPD1 isoenzym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a57a51cbab6a1b1909862bc4c69a736
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6
Over-expression of Adamts1 in mice alters bone mineral density
Autor: Kenneth B. Jonsson, Harriet Andersén, Lijuan Hu, Thomas Lind, Håkan Melhus, Anne Edenro, Mohammad Bohlooly-Y
Publikováno v: Journal of Bone and Mineral Metabolism. 30:304-311
ADAMTS1, a secreted multifunctional metalloproteinase with disintegrin and thrombospondin motifs, is an early response gene of parathyroid hormone (PTH) in osteoblasts. Mice engineered to lack Adamts1 are smaller compared to wild-type (WT) mice and A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1ad08572c1f49557ad8ec6376d1bc2
https://doi.org/10.1007/s00774-011-0322-4
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7
Osteoporosis in MCHR1-deficient mice
Autor: Stephan Hjorth, Jan Törnell, Lennart Svensson, Michael Snaith, Annika Åstrand, Margit Mahlapuu, David G.A. Morgan, Harriet Andersén, Mohammad Bohlooly-Y, Claes Ohlsson
Publikováno v: Biochemical and Biophysical Research Communications. 318:964-969
It is well recognized that the hypothalamus is of central importance in the regulation of food intake and fat mass. Recent studies indicate that it also plays an important role in the regulation of bone mass. Melanin concentrating hormone (MCH) is hi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6a712d66b8a6f297434676e3bb7c37
https://doi.org/10.1016/j.bbrc.2004.04.122
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8
LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux
Autor: Sander Kersten, Xiufeng Xu, G. H. Thoresen, Arild Chr. Rustan, Nina Pettersen Hessvik, M. A. Baltzersen, Harriet Andersén, Mark V. Boekschoten
Publikováno v: American Journal of Physiology. Endocrinology and Metabolism, 298, E602-E613
American Journal of Physiology. Endocrinology and Metabolism 298 (2010)
Liver X receptors (LXRs) are important regulators of cholesterol, lipid, and glucose metabolism and have been extensively studied in liver, macrophages, and adipose tissue. However, their role in skeletal muscle is poorly studied and the functional r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c92a30c6f64f6a7d0adcb5541d79671
https://pubmed.ncbi.nlm.nih.gov/19996385
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9
Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity
Autor: Sara Larsdotter, David G.A. Morgan, Harriet Andersén, Annika Åstrand, Margit Mahlapuu, Claes Ohlsson, Mohammad Bohlooly-Y, Mike Snaith, Jan Törnell
Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology. 287(4)
Melanin-concentrating hormone (MCH) plays an important role in energy balance. The current studies were carried out on a new line of mice lacking the rodent MCH receptor (MCHR1−/− mice). These mice confirmed the previously reported lean phenotype
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea3d9b7f7bd1c73daece8ae2aaeeb08
https://pubmed.ncbi.nlm.nih.gov/15130877
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