Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Autor: Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

IL-10 production by B cells is integral to regulation and resolution of inflammation. Here the authors show that cholesterol metabolism can control B cell IL-10 production via a geranylgeranyl pyrophosphate-dependent mechanism.

Externí odkaz: https://doaj.org/article/a13c8e4f4fa14c78ae7364c2bdf52f9c

Dendritic cells, T cells and their interaction in rheumatoid arthritis

Autor: Pascale Wehr, Soi Cheng Law, Harriet A. Purvis, Ranjeny Thomas

Publikováno v: Clinical & Experimental Immunology

Summary Dendritic cells (DCs) are the key professional antigen-presenting cells which bridge innate and adaptive immune responses, inducing the priming and differentiation of naive to effector CD4+ T cells, the cross-priming of CD8+ T cells and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d1966709b541fff61c07155d5a240c
https://doi.org/10.1111/cei.13256

Cholesterol metabolism drives regulatory B cell function

Autor: Klaus Okkenhaug, Michael Wood, Anita Chandra, Esperanza Perucha, Jack A. Bibby, Helen J. Lachmann, Thomas Hayday, Claudia Kemper, Andrew P. Cope, Harriet A. Purvis

SummaryRegulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of a regulatory program in human B cells is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d28610c3ab7a31074520f822a6059d

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

Autor: Fiona Clarke, Georgina H. Cornish, David Depoil, Harriet A. Purvis, Stephen J. Thompson, Cristina Sanchez-Blanco, Michael L. Dustin, Xuezhi Dai, David J. Rawlings, Andrew P. Cope, Rose Zamoyska

Publikováno v: Sanchez-Blanco, C, Clarke, F, Cornish, G H, Depoil, D, Thompson, S J, Dai, X, Rawlings, D J, Dustin, M L, Zamoyska, R, Cope, A P & Purvis, H A 2018, ' Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses ', Journal of autoimmunity, vol. 94, pp. 45-55 . https://doi.org/10.1016/j.jaut.2018.07.008
Sanchez-blanco, C, Clarke, F, Cornish, G H, Depoil, D, Thompson, S J, Dai, X, Rawlings, D J, Dustin, M L, Zamoyska, R, Cope, A P & Purvis, H A 2018, ' Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses ', Journal of Autoimmunity . https://doi.org/10.1016/j.jaut.2018.07.008
Journal of Autoimmunity

A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e4f5c7f5be3be4eb3afd9a11476f9b
http://ora.ox.ac.uk/objects/uuid:

Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity

Autor: Juliette Griffié, Garth L. Burn, Dylan M. Owen, Katarzyna Potrzebowska, Rebecca J. Brownlie, Malin Samuelsson, Nicolas Pernodet, Georgina H. Cornish, Sophie Minoughan, Mark Yates, George W. Ashdown, Cristina Sanchez-Blanco, Harriet A. Purvis, Timothy J. Vyse, Lena Svensson, Vicky L. Morrison, Fiona Clarke, Andrew P. Cope, Rose Zamoyska

Publikováno v: Burn, G L, Cornish, G H, Potrzebowska, K, Samuelsson, M, Griffié, J, Minoughan, S, Yates, M, Ashdown, G, Pernodet, N, Morrison, V L, Sanchez-Blanco, C, Purvis, H, Clarke, F, Brownlie, R J, Vyse, T J, Zamoyska, R, Owen, D M, Svensson, L M & Cope, A P 2016, ' Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity ', Science Signaling, vol. 9, no. 448, ra99 . https://doi.org/10.1126/scisignal.aaf2195

Integrins are heterodimeric transmembrane proteins that play a fundamental role in the migration of leukocytes to sites of infection or injury. We found that protein tyrosine phosphatase nonreceptor type 22 (PTPN22) inhibits signaling by the integrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d374e90d4dc9aa7d57e4df9a168dae6
https://eprints.gla.ac.uk/132213/1/132213.pdf