Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Harri Santa"'
Autor:
Ulf-Håkan Stenman, Miikka Pakkala, Ale Närvänen, Mikael Peräkylä, Harri Santa, Jouko Vepsäläinen, Anu Jylhäsalmi, Ping Wu, Jari Leinonen
Publikováno v:
Journal of Peptide Science. 10:439-447
Prostate-specific antigen (PSA), a member of the kallikrein sub-group of the trypsin serine protease family, is a widely used marker for prostate cancer. Several sequences with specific binding to PSA have been identified by using phage display pepti
Autor:
Reino Laatikainen, Hilkka Lankinen, Pentti Kuusela, Ale Närvänen, Jari Ratilainen, Timo Korjamo, Harri Santa, Helena Hujakka
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1601-1607
Dimeric derivative of antimicrobial peptide amide Temporin A (TA) was synthesized by using a new branching unit 3-N,N-di(3-aminopropyl)amino propanoic acid (DAPPA), which allows building of the parallelly symmetric alpha-helical structures. Antimicro
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 16:1033-1041
Folding of the hexapeptide MSALNT and the octapeptide NMSALNTL were investigated using 2.8 ns molecular dynamics (MD) simulations in aqueous solution. In the simulation, the central sequence SALN of the hexapeptide folded rapidly within 200 ps into a
Autor:
Rauno Mäntyjärvi, Harri Santa, Janne T. A. Saarela, Tuomas Virtanen, Jaakko Rautianen, Marja Rytkönen, Reino Laatikainen
Publikováno v:
Journal of Protein Chemistry. 17:657-662
The most important allergenic protein in cow dander and urine is Bos d 2. It is proposed to belong to the family of lipocalins, which are proteins capable of binding small hydrophobic molecules. The allergenic properties of Bos d 2 indicate an intera
Publikováno v:
European Journal of Biochemistry. 250:19-29
Flagellin proteins lacking the N- or C-terminus form polymers of reduced filament stability and straight morphology, in contrast to the coiled native flagella. In the present study, the N-terminal amino acid sequence of flagellins of the anaerobic be
Publikováno v:
Journal of the American Chemical Society. 117:11006-11010
Autor:
Matti Leisola, Ossi Pastinen, Tarja Parkkinen, Ossi Turunen, Juha Rouvinen, Harri Santa, Johanna Karimäki
Publikováno v:
Protein engineering, designselection : PEDS. 17(12)
Xylose isomerase (XI) catalyzes the isomerization and epimerization of hexoses, pentoses and tetroses. In order to clarify the reasons for the low reaction efficiency of a pentose sugar, L-arabinose, we determined the crystal structure of Streptomyce
Autor:
Johanna Karimäki, Juha Kammonen, Olli Lehtonen, Matti Leisola, Ossi Pastinen, Ossi Turunen, Harri Santa
Publikováno v:
Biochimica et biophysica acta. 1749(1)
We used molecular dynamics simulations to study how a non-natural substrate, L-ribose, interacts with the active site of Actinoplanes missouriensis xylose isomerase. The simulations showed that L-ribose does not stay liganded in the active site in th
Publikováno v:
Protein engineering. 15(8)
Free energies of the alpha(r)beta and betabeta conformations of 14 tetrapeptides, based on the sequence SALN and protein X-ray structures, were calculated using molecular dynamics simulations and MM-PBSA calculations. The alphaalpha conformations of
Autor:
Mogens S. Lehmann, Edward Darzynkiewicz, Harri Lönnberg, Harri Santa, Tadashi Tokii, Mourits Nielsen, Marjo Lahti
Publikováno v:
Acta Chemica Scandinavica. 44:636-638