Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Harper C. Vansteenhouse"'
Autor:
Christy L Trejo, Miloš Babić, Elliot Imler, Migdalia Gonzalez, Sergei I Bibikov, Peter J Shepard, Harper C VanSteenhouse, Joanne M Yeakley, Bruce E Seligmann
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212031 (2019)
We describe the use of a ligation-based targeted whole transcriptome expression profiling assay, TempO-Seq, to profile formalin-fixed paraffin-embedded (FFPE) tissue, including H&E stained FFPE tissue, by directly lysing tissue scraped from slides wi
Externí odkaz:
https://doaj.org/article/24977ed9ec084aca885a049108f285f0
Autor:
Joanne M Yeakley, Peter J Shepard, Diana E Goyena, Harper C VanSteenhouse, Joel D McComb, Bruce E Seligmann
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178302 (2017)
The use of gene expression signatures to classify compounds, identify efficacy or toxicity, and differentiate close analogs relies on the sensitivity of the method to identify modulated genes. We used a novel ligation-based targeted whole transcripto
Externí odkaz:
https://doaj.org/article/d403b6190c4a45f3b409e67cbb03ebb5
Autor:
Andrea Lees, D. Longley, Bruce Seligmann, Peter T. Gallagher, Philip D Dunne, Darragh G. McArt, Simon S. McDade, Mark Wappett, Wendy L. Allen, Gerard P. Quinn, Harper C. VanSteenhouse, Sarah Maguire, Tamas Sessler
Publikováno v:
Cancer Research. 80:3205-3205
Background: Transcriptional predictors are increasingly important for sub-typing cancer patients and understanding disease aetiology, predicting patient outcomes and response to treatment. Colorectal cancers (CRC) can be classified by transcriptional
Autor:
Sergei I. Bibikov, Harper C. VanSteenhouse, Elliot Imler, Milos Babic, Joanne M. Yeakley, Christy L. Trejo, Peter J. Shepard, Migdalia Gonzalez, Bruce Seligmann
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212031 (2019)
PLoS ONE
PLoS ONE
We describe the use of a ligation-based targeted whole transcriptome expression profiling assay, TempO-Seq™, to profile formalin-fixed paraffin-embedded (FFPE) tissue, including H&E stained FFPE tissue, by directly lysing tissue scraped from slides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d159a8cd5ce2c3a85149c38ca9ddff
Publikováno v:
Development Genes and Evolution. 220:77-87
The biological function of a cell-type-specific glycosylation of an adhesion molecule belonging to the L1CAM immunoglobulin superfamily was previously determined in the nervous system of the embryonic leech, Hirudo medicinalis. The Lan3-2 glycoepitop
Autor:
Xiangshu Jin, Harper C VanSteenhouse, Lawrence Shapiro, Shoshana Posy, Julia Brasch, Barbara Ranscht, Fabiana Bahna, Jeremie Vendome, Barry Honig, O.J. Harrison, Goran Ahlsen, Niccolò Zampieri, Phini S Katsamba, Carlo Ciatto, Thomas M. Jessell
Publikováno v:
Nature Structural & Molecular Biology. 17:339-347
Vertebrate genomes encode nineteen “classical” cadherins and about a hundred non-classical cadherins. Adhesion by classical cadherins depends on binding interactions in their amino terminal EC1 domains, which swap N-terminal β-strands between pa
Publikováno v:
Toxicology Letters. 280:S295
A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling
Autor:
Peter J. Shepard, Bruce Seligmann, Diana E. Goyena, Harper C. VanSteenhouse, Joel Mccomb, Joanne M. Yeakley
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0178302 (2017)
PLoS ONE, Vol 12, Iss 5, p e0178302 (2017)
The use of gene expression signatures to classify compounds, identify efficacy or toxicity, and differentiate close analogs relies on the sensitivity of the method to identify modulated genes. We used a novel ligation-based targeted whole transcripto
Autor:
Harper C. VanSteenhouse, Alex Merrick, R. Shah, Joanne M. Yeakley, Milos Babic, Scott S. Auerbach, D. Mav, B. Seligmann, Richard S. Paules, Peter J. Shepard
Publikováno v:
Toxicology Letters. 258:S279
Autor:
Harper C. VanSteenhouse, Anja Wilmes, Paul Jennings, Bruce Seligmann, Mathieu Vinken, Gamze Ates, Alice Limonciel, Bob van de Water, Manfred Watzele, Joanne M. Yeakley, Peter J. Shepard, Giada Carta
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 92(8), 2517-2531. Springer Verlag
Archives of Toxicology, 92(8), 2517-2531
Limonciel, A, Ates, G, Carta, G, Wilmes, A, Watzele, M, Shepard, P J, VanSteenhouse, H C, Seligmann, B, Yeakley, J M, van de Water, B, Vinken, M & Jennings, P 2018, ' Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq ', Archives of Toxicology, vol. 92, no. 8, pp. 2517-2531 . https://doi.org/10.1007/s00204-018-2256-2
Archives of Toxicology, 92(8), 2517-2531. Springer Verlag
Archives of Toxicology, 92(8), 2517-2531
Limonciel, A, Ates, G, Carta, G, Wilmes, A, Watzele, M, Shepard, P J, VanSteenhouse, H C, Seligmann, B, Yeakley, J M, van de Water, B, Vinken, M & Jennings, P 2018, ' Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq ', Archives of Toxicology, vol. 92, no. 8, pp. 2517-2531 . https://doi.org/10.1007/s00204-018-2256-2
The utilisation of genome-wide transcriptomics has played a pivotal role in advancing the field of toxicology, allowing the mapping of transcriptional signatures to chemical exposures. These activities have uncovered several transcriptionally regulat