Zobrazeno 1 - 10 of 181 pro vyhledávání: '"Harold. J Jennings"'
1
Conjugation of Meningococcal Lipooligosaccharides Through Their Non-Reducing Terminus Results in Improved Induction a Protective Immune Response
Autor: Andrzej Gamian, Harold J. Jennings, Marek Drab, Małgorzata Mieszała
Publikováno v: Archivum Immunologiae et Therapiae Experimentalis
The present studies prove that conjugation of meningococcal lipooligosaccharides through their non-reducing terminus conserves their inner epitopes resulting in conjugates potent to induce a protective immune response. Four different oligosaccharides
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8675402ffd715ecbd0c93d4b1e47c2
https://doi.org/10.1007/s00005-019-00542-9
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3
Sialyltransferase inhibitors: consideration of molecular shape and charge/hydrophobic interactions
Autor: Rishi Kumar, Nam Huan Khieu, Milan Bhasin, Harold C. Jarrell, Wei Zou, Michel Gilbert, Margaret Hsieh, Harold J. Jennings, Ravindranath Nasi
Publikováno v: Carbohydrate Research. 378:45-55
In order to evaluate the importance of molecular shape of inhibitor molecules and the charge/H-bond and hydrophobic interactions, we synthesized three types of molecules and tested them against a sialyltransferase. The first type of compounds were de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e081e337033f4db78eee1bef814818a8
https://doi.org/10.1016/j.carres.2012.12.017
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4
Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci
Autor: Lauren E. Abrey, Lee M. Krug, Govind Ragupathi, Harold J. Jennings, Ronglai Shen, Chandra Hood, Constantine George, Philip O. Livingston, Feng Hong, Mark G. Kris
Publikováno v: Cancer Immunology, Immunotherapy. 61:9-18
Polysialic acid (polySA) is a polymer side chain bound to the neural cell adhesion molecule that is extensively expressed on the surface of small cell lung cancer (SCLC) cells. In our previous study, a robust antibody response was noted in patients w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bff6ae904086d2d8a71c2b4dd820cd
https://doi.org/10.1007/s00262-011-1083-6
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5
Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching
Autor: Lawrence C. Paoletti, Wojcieck Jachymek, Harold J. Jennings, Hilde-Kari Guttormsen, Dennis L. Kasper, Keith G. Mansfield
Publikováno v: Proceedings of the National Academy of Sciences. 105:5903-5908
Many pathogens are sheltered from host immunity by surface polysaccharides that would be ideal as vaccines except that they are too similar to host antigens to be immunogenic. The production of functional IgG is a desirable response to vaccines; beca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc0a33190a38b859c18ae126911b708
https://doi.org/10.1073/pnas.0710799105
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7
Synthesis of mono- and di-sialophospholipids via the H-phosphonate approach
Autor: Harold J Jennings, Hongbin Yan
Publikováno v: Canadian Journal of Chemistry. 84:540-545
To overcome their inherent instability, stable modified mono- and di-sialophospholipids of the group C meningococcal polysaccharide were synthesized. Stability was achieved by introducing a spacer between the sialic acid residue and the phospholipid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a53478e07fee168d6b88c08108c93199
https://doi.org/10.1139/v06-031
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8
Bioengineering of Surface GD3 Ganglioside for Immunotargeting Human Melanoma Cells
Autor: Michel Gilbert, Harold J. Jennings, Tianmin Liu, Wei Zou, Silvia Borrelli, Robert Pon
Publikováno v: Journal of Biological Chemistry. 279:25390-25399
N-Propionyl, N-butyryl (N-Bu), and N-benzoyl mannosamine, as precursors of sialic acid biosynthesis, were incubated with human melanoma SK-MEL-28 cells and resulted in the replacement of N-acetyl groups on the cell surface sialic acid residues, inclu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b62f650ad6440081006a5db321dac8
https://doi.org/10.1074/jbc.m402787200
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9
Serological and conformational properties ofE. coliK92 capsular polysaccharide and itsN-propionylated derivative both illustrate that induced antibody does not recognize extended epitopes of polysialic acid: Implications for a comprehensive conjugate vaccine against groups B and CN. meningitidis
Autor: Jean-Robert Brisson, Qingling Yang, Harold J. Jennings, Robert Pon, Nam Huan Khieu
Publikováno v: Canadian Journal of Chemistry. 80:1055-1063
The capsular polysaccharide of E. coli K92 (K92P) contains elements in common with the capsular polysaccharides of both groups B and C N. meningitidis, and may therefore form the basis of a bivalent vaccine. In an attempt to augment the cross-protect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3be47034af78894bed1b31c32adb273b
https://doi.org/10.1139/v02-141
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10
Biochemical Engineering of Surface α2–8 Polysialic Acid for Immunotargeting Tumor Cells
Autor: Zhongwu Guo, Tianmin Liu, Harold J. Jennings, Subash Sad, Qingling Yang
Publikováno v: Journal of Biological Chemistry. 275:32832-32836
To target tumor cells for immunotherapy, we evaluated the feasibility of altering the epitopes on the surface polysialic acid of tumor cells. A precursor (N-propionylmannosamine), when incubated with leukemic cells, RBL-2H3 and RMA, resulted in subst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938c5d65427b373d1df97b2a0e576bfb
https://doi.org/10.1074/jbc.c000573200
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