Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Harold T. Smith"'
Publikováno v:
Bioanalysis. 4:1429-1443
Background: In support of a pilot clinical trial using acetaminophen as the model compound to assess dried blood spot (DBS) sampling as the method for clinical pharmacokinetic sample collection, a novel sensitive LC–MS/MS method was developed and v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc1aeb0c452281e1746a8e1636aaa13
https://doi.org/10.4155/bio.12.119
https://doi.org/10.4155/bio.12.119
Autor:
Rajesh Karan, Karin Meiser, Jingli Duan, Qi Yin, Gangadhar Sunkara, Harold T. Smith, Jin Chen
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 50:33-43
Objective The efficacy and safety of valsartan/amlodipine combination have been demonstrated for the treatment of hypertension. In China, where the prevalence of hypertension is increasing the pharmacokinetic study of valsartan, amlodipine assumes si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261de1b8b4a98c90aa410812194f5ac8
https://doi.org/10.5414/cp201601
https://doi.org/10.5414/cp201601
Publikováno v:
Bioanalysis. 3:967-972
Background: In this case study, urine samples were collected and transferred before the presence of a small degree of nonspecific binding was identified for the analyte of interest in human urine. The approach taken to address the issue was to use st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52b492929837c499ee5d3ad09ea8842
https://doi.org/10.4155/bio.11.65
https://doi.org/10.4155/bio.11.65
Publikováno v:
Journal of Chromatography B. 878:583-589
Analyte loss due to non-specific binding, especially container surface adsorption, is not uncommon in the quantitative analysis of urine samples. In developing a sensitive LC-MS/MS method for the determination of a drug candidate, BAF312, in human ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917e327cc09becaa3f1ba8f018fba35b
https://doi.org/10.1016/j.jchromb.2009.12.031
https://doi.org/10.1016/j.jchromb.2009.12.031
Publikováno v:
Toxicology. 213:1-12
Transplantation in nonhuman primates, in particular using solid organs from porcine donors, requires an efficacious induction immunosuppression. Besides biologicals, the low molecular weight drugs used include cyclophosphamide (CyP) and methotrexate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a22863f801aaaf146ac059e5cd2b9e
https://doi.org/10.1016/j.tox.2005.03.017
https://doi.org/10.1016/j.tox.2005.03.017
Autor:
Harold T. Smith, Henk-Jan Schuurman
Publikováno v:
Xenotransplantation. 12:72-75
Background: In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. Methods: These v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd9d97f320a05c3bbab9dd2fb7a5e25
https://doi.org/10.1111/j.1399-3089.2004.00186.x
https://doi.org/10.1111/j.1399-3089.2004.00186.x
Autor:
James F. McLeod, Harold T. Smith, Pratapa Prasad, Hilde Bigler, Gangadhar Sunkara, Yibin Wang, Monica Ligueros-Saylan
Publikováno v:
Current Medical Research and Opinion. 20:41-48
The potential for a drug interaction was investigated between nateglinide, an oral antidiabetic agent, and acenocoumarol, an oral anticoagulant, as these drugs are primarily metabolized via CYP2C9.A two-period, randomized, double-blind, two-way cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6382112ac64cf545cbf623472e5a1a
https://doi.org/10.1185/030079903125002685
https://doi.org/10.1185/030079903125002685
Autor:
James F. McLeod, James Lee, Harold T. Smith, Damayanthi Devineni, Pratapa Prasad, Yulia H. Walter
Publikováno v:
The Journal of Clinical Pharmacology. 43:163-170
Treatment of hyperglycemia in patients with diabetes mellitus and renal insufficiency is complicated by altered pharmacokinetics of hypoglycemic agents. This study evaluated the pharmacokinetic profile and safety of nateglinide, an amino acid derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913b48849ac3897b4942d09445ae82bd
https://doi.org/10.1177/0091270002239825
https://doi.org/10.1177/0091270002239825
Publikováno v:
Journal of Cardiovascular Pharmacology. 37:502-511
Fluvastatin sodium (Lescol, Novartis Pharmaceutical Corp., East Hanover, NJ, U.S.A.), a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG Co-A) reductase inhibitor that limits cholesterol biosynthesis, is available as a 40-mg immediate-release formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7bee762e98d40227d9a3a965d71b93
https://doi.org/10.1097/00005344-200105000-00002
https://doi.org/10.1097/00005344-200105000-00002
Autor:
Jordan M. Dunitz, Ramona L. Doyle, David Tudor, James E. Loyd, John M. Kovarik, Marshall I. Hertz, R. Wong, Lin Dou, Silke Appel-Dingemanse, Kimberly A Chappell, Arlene A. Stecenko, Harold T. Smith, Timothy R. Brazelton, Randall E. Morris
Publikováno v:
The Journal of Heart and Lung Transplantation. 20:330-339
Background RAD is a novel macrolide with potent immunosuppressive and antiproliferative activities. This study characterizes the safety, tolerability, and pharmacokinetics of two different single oral doses of RAD in stable lung and heart/lung transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24a40aa3e030043e781aef5811e897e
https://doi.org/10.1016/s1053-2498(00)00232-1
https://doi.org/10.1016/s1053-2498(00)00232-1