Výsledky vyhledávání - "Harold Phillip Koeffler"

Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status

Autor: Hélène Marijon, Harold Phillip Koeffler, Hua Chang, Aimery de Gramont, Sharon Shacham, Dhong Hyun Lee, Sigal Gery, Yosef Landesman

Publikováno v: Oncotarget, vol 12, iss 18
Oncotarget

Triple negative breast cancer (TNBC) is a deadly disease with limited treatment options. Selinexor is a selective inhibitor of nuclear export that binds covalently to exportin 1 thereby reactivating tumor suppressor proteins and downregulating expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e00f9d79c00e5aaf274811f9110633e
https://escholarship.org/uc/item/3hb126p3

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LAMC2 as a therapeutic target for cancers

Autor: Glenn D. Braunstein, Manoj Garg, Harold Phillip Koeffler

Publikováno v: Expert Opinion on Therapeutic Targets. 18:979-982

Cancer is the leading cause of morbidity and mortality in developed countries and the second major cause of death in developing countries. Laminins are crucial proteins in the basal lamina (one of the layers of the basement membrane), and these form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2d8dfd2fb548dfeeed73a2e9eec11f
https://doi.org/10.1517/14728222.2014.934814

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