Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Harold Monro Moody"'
Autor:
Remco Merkx, John A. W. Kruijtzer, Peter J. L. M. Quaedflieg, Harold Monro Moody, Theodorus J. G. M. van Dooren, Dirk T. S. Rijkers, Rob M. J. Liskamp, Timo Nuijens, Claudia Cusan
Publikováno v:
Advanced Synthesis & Catalysis. 352:2399-2404
Chemoenzymatic peptide synthesis is potentially the most cost-efficient technology for the synthesis of short and medium-sized peptides with some important advantages. For instance, stoichiometric amounts of expensive coupling reagents are not requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe948bab367c2eb733bccb91f4447fc
https://doi.org/10.1002/adsc.201000313
https://doi.org/10.1002/adsc.201000313
Autor:
Vytas K. Švedas, Wilhelmus H J Boosten, Alexander L Bukhanov, M. I. Youshko, Harold Monro Moody
Publikováno v:
Biotechnology and Bioengineering. 85:323-329
Advantages of performing penicillin acylase-catalyzed synthesis of new penicillins and cephalosporins by enzymatic acyl transfer to the beta-lactam antibiotic nuclei in the supersaturated solutions of substrates have been demonstrated. It has been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168923ec152165a19525363d84852c67
https://doi.org/10.1002/bit.10863
https://doi.org/10.1002/bit.10863
Publikováno v:
Tetrahedron: Asymmetry. 14:2613-2617
A new strategy for the biocatalytic resolution of (R,S)-phenylglycinonitrile, a crucial intermediate in the antibiotic industry, has been developed. While former techniques exploit nitrilases or combinations of nitrile hydratases and amidases, manipu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b28b8ac09883e295c46861b3db5cdd
https://doi.org/10.1016/s0957-4166(03)00523-8
https://doi.org/10.1016/s0957-4166(03)00523-8
Autor:
E.C. Roos, W. Berendsen, J.L. VanRoon, Johannes Tramper, C.B. Fretz, C.G.P.H. Schroën, P.J. Kroon, Harold Monro Moody, M. Strubel, Anja E.M. Janssen, V.H. DeBruin
Publikováno v:
Biotechnology and Bioengineering. 80:331-340
In this study the influence of diffusion limitation on enzymatic kinetically controlled cephalexin synthesis from phenylglycine amide and 7-aminodeacetoxycephalosporinic acid (7-ADCA) was investigated systematically. It was found that if diffusion li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d8898b1a9b2a8afa42708ceb298519
https://doi.org/10.1002/bit.10384
https://doi.org/10.1002/bit.10384
Autor:
Hendrik H. Beeftink, J. M. VanderLaan, P. S. Tjeerdsma, C.G.P.H. Schroën, E. DeVroom, Johannes Tramper, Harold Monro Moody, Vincent Nierstrasz, Anja E.M. Janssen, R. Bosma, P.J. Kroon
Publikováno v:
Biotechnology and Bioengineering. 80:144-155
Integrated process concepts for enzymatic cephalexin synthesis were investigated by our group, and this article focuses on the integration of reactions and product removal during the reactions. The last step in cephalexin production is the enzymatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612efda8ed53938abca515d38f041978
https://doi.org/10.1002/bit.10348
https://doi.org/10.1002/bit.10348
Autor:
R. Bosma, C.G.P.H. Schroën, M. J. Hoogschagen, Johannes Tramper, Hendrik H. Beeftink, P.J. Kroon, Anja E.M. Janssen, Vincent Nierstrasz, Harold Monro Moody
Publikováno v:
Biotechnology and Bioengineering. 73:171-178
During enzymatic kinetic synthesis of cephalexin, an activated phenylglycine derivative (phenylglycine amide or phenylglycine methyl ester) is coupled to the nucleus 7-aminodeacetoxycephalosporanic acid (7-ADCA). Simultaneously, hydrolysis of phenylg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::477c84489d0dc4c8896cc14308bdd3ba
https://doi.org/10.1002/bit.1049
https://doi.org/10.1002/bit.1049
Autor:
M. I. Youshko, Luuk M. van Langen, Vytas K. Švedas, Fred van Rantwijk, Harold Monro Moody, Erik de Vroom, Roger A. Sheldon
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 10:509-515
Penicillin acylase-catalyzed ampicillin synthesis via acyl group transfer in aqueous solution is highly dependent on the initial substrate concentration. The solubility of one substrate, 6-aminopenicillanic acid (6-APA), can be advantageously enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5145e0ea4481a88f0f06e4bffc0e94e
https://doi.org/10.1016/s1381-1177(00)00091-6
https://doi.org/10.1016/s1381-1177(00)00091-6
Autor:
Quirinus B. Broxterman, Bernard Kaptein, Harold Monro Moody, Johan Kamphuis, Wilhelmus H. J. Boesten
Publikováno v:
Tetrahedron Letters. 35:1777-1780
Enantiomerically pure 2,2-disubstituted 2-amino-ethanols are prepared in 65 – 99% yield by reduction of a , a -disubstituted amino acid amides using liquid sodium metal in refluxing 1-propanol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bfa44e7ca333fa439ce5c1ee7f593e2
https://doi.org/10.1016/0040-4039(94)88344-0
https://doi.org/10.1016/0040-4039(94)88344-0
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8226d67a4ec16c9487f819bcbcba0fcb
https://doi.org/10.1002/chin.199434089
https://doi.org/10.1002/chin.199434089
Publikováno v:
ChemInform. 25
The synthesis of (S)-(+)-cericlamine (S)-1 and related disubstituted amino alcohols is described as an example of the stereoselective synthesis of amino alcohols from disubstituted amino acids and their corresponding amides. Thus, the amino alcohols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48e2ab80198f55ad6e55be3134248a1a
https://doi.org/10.1002/chin.199441226
https://doi.org/10.1002/chin.199441226