Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Harold Malone"'
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Supplementary Tables 1-3, Figure Legends 1-6 from Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f909ef46a03d1570a27d99c5261e2b
https://doi.org/10.1158/1078-0432.22441917.v1
https://doi.org/10.1158/1078-0432.22441917.v1
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Purpose: The extensive involvement of the HER kinases in epithelial cancer suggests that kinase inhibitors targeting this receptor family have the potential for broad spectrum antitumor activity. BMS-690514 potently inhibits all three HER kinases, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33f1ae66761ffc51c82294bcb244134
https://doi.org/10.1158/1078-0432.c.6518787
https://doi.org/10.1158/1078-0432.c.6518787
Autor:
Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
Supplementary Figures 1-6 from Antitumor and Antiangiogenic Activities of BMS-690514, an Inhibitor of Human EGF and VEGF Receptor Kinase Families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10077e61e239f1a813c40834f158a23d
https://doi.org/10.1158/1078-0432.22441920
https://doi.org/10.1158/1078-0432.22441920
Autor:
Kurex Sidik, Matthew Fronheiser, Yu-Wen Li, Adrienne Pena, Feng Luo, Linda J. Bristow, Patrick L Chow, Haiying Tang, Rick L. Pieschl, Daniel W. Kukral, Gabriel Tobon, Harold Malone, Wendy Hayes
Publikováno v:
Journal of Psychopharmacology. 32:146-155
Major depressive disorder is a leading cause of disability globally. Improvements in the efficacy of antidepressant therapy are needed as a high proportion (>40%) of individuals with major depressive disorder fail to respond adequately to current tre
Autor:
Lisa Salvador, Richard Martin, Raju Mohan, Philip Wastall, Zhaoqing Wang, John A. Lupisella, Kamelia Behnia, Paul G. Sleph, Todd G. Kirchgessner, Petia Shipkova, Gayani Fernando, Jane Zhang, Carol S. Ryan, Rongan Zhang, Shuyan Du, Tong Li, Harold Malone, Ellen K. Kick, Glenn H. Cantor, Jun Zhu, Yu Chen Barrett, Jacek Ostrowski, Long Yuan, Denise Grimm, Aiqing He, John S. Lee, Robert J.A. Frost, Mohit D. Gandhi, Ricardo Garcia, Robert J. Garmise, Xiaoqin Liu
Publikováno v:
Cell Metabolism. 24:223-233
The development of LXR agonists for the treatment of coronary artery disease has been challenged by undesirable properties in animal models. Here we show the effects of an LXR agonist on lipid and lipoprotein metabolism and neutrophils in human subje
Autor:
Rajeev S. Bhide, Daniel W. Kukral, Harold Malone, Barri Wautlet, John T. Hunt, Anne Lewin, Joel C. Barrish, Bala Krishnan, Steven Mortillo, Joseph Fargnoli, Zhen-Wei Cai, Louis J. Lombardo, Benjamin J. Henley, Susan Galbraith, Robert Jeyaseelan
Publikováno v:
Molecular Cancer Therapeutics. 9:369-378
Tumor angiogenesis is a complex and tightly regulated network mediated by various proangiogenic factors. The fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) family of growth factors, and associated tyrosine kinase recepto
Autor:
Benjamin J. Henley, Bala Krishnan, Amy Hammell, Daniel W. Kukral, John T. Hunt, Joseph Fargnoli, Brian E. Fink, Derek J. Norris, Francis Y.F. Lee, Chiang Yu, Tai Wai Wong, Christine Hilt, Gregory D. Vite, Harold Malone, Ashvinikumar V. Gavai, Craig R. Fairchild, Stuart Emanuel, Anne Lewin, Simone Oppenheimer
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(12)
Purpose: The extensive involvement of the HER kinases in epithelial cancer suggests that kinase inhibitors targeting this receptor family have the potential for broad spectrum antitumor activity. BMS-690514 potently inhibits all three HER kinases, an
Glyburide-reversible cardioprotective effects of BMS-180448: functional and energetic considerations
Publikováno v:
Journal of cardiovascular pharmacology. 29(1)
Adenosine triphosphate (ATP)-sensitive potassium channel openers as a class exert cardioprotective effects, and we can separate vasodilator from glyburide-reversible cardioprotective activity in cromakalim analogs (e.g., BMS-180448). The purpose of t
Autor:
Ronald W. Behling, Harold Malone
Publikováno v:
Journal of molecular and cellular cardiology. 27(9)
There is ample evidence that potassium channel openers protect the ischaemic myocardium. Although the protective mechanism is unknown. indirect evidence suggests that potassium channel openers reduce calcium influx during ischaemia which may explain