Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Harold M. Wright"'
Autor:
Michael J. Overman, Ramzi Melhem, Mariela A. Blum-Murphy, Claudia Ramos, Lina Petrosyan, Jack Li, Jessica K Perer, Hui Zou, Ming Wang, Harold M Wright
Publikováno v:
Journal of Clinical Oncology. 41:TPS765-TPS765
TPS765 Background: PT886 is a novel bispecific antibody that targets Claudin 18.2 (CLDN18.2) and CD47. CLDN18.2 is overexpressed in a significant proportion of gastric and pancreatic adenocarcinomas and its restricted expression makes it a promising
Autor:
Adrian Liew, David C. Wheeler, Kate Chong, Marvin Sinsakul, Mary Beaucage, Mototsugu Tanaka, Jonathan Barratt, Maarten W. Taal, Aminu K. Bello, Charu Malik, Glenda V. Roberts, Hiddo J.L. Heerspink, Yoshihisa Yamada, Laura Sola, Charlotte Jones-Burton, Thomas F. Hiemstra, Reiko Nakashima, Katherine R. Tuttle, Shuchi Anand, Benjamin O. Wolthers, Jo Ann Donner, Takayuki Hamano, Debasish Banerjee, Rajiv Agarwal, Jennifer B. Rose, Ifeoma Ulasi, Masaomi Nangaku, Duane Sunwold, Vlado Perkovic, NB Argent, Robert Lawatscheck, Vivekanand Jha, Richard Haynes, Dick de Zeeuw, Fergus Caskey, Amer Joseph, Madeleine Warren, Michele Trask, Christoph Wanner, Robert D. Toto, Ian H. de Boer, Kenneth W. Mahaffey, Harold M. Wright, Meg Jardine, Hans Vorster, William Canovatchel, Adeera Levin, Kai-Uwe Eckardt, Marcello Tonelli, Noah L. Rosenberg, Hrefna Gudmundsdottir, Rhys Evans, Agnes B. Fogo, David Harris, Thomas Idorn, Amy R. Sood, Sandrine Damster, A. A. Bernardo, David W. Johnson, Saraladevi Naicker, Julie H. Ishida, William E. Smoyer, Roberto Pecoits Filho, Elena Zakharova, William G. Herrington, Shahnaz Shahinfar, Aliza Thompson, Lesley A. Inker, Matthias Kretzler, Allison Tong, Harold I. Feldman, Louise Moist, Josef Coresh, Elena Babak, Sibylle J. Hauske, Jaime D. Blais, Charles A. Herzog, Uptal D. Patel, Johannes F.E. Mann, Audrey Koitka-Weber, Bénédicte Stengel
Publikováno v:
Kidney International, 98(4), 849-859. ELSEVIER SCIENCE INC
Kidney failure is an important outcome for patients, clinicians, researchers, healthcare systems, payers, and regulators. However, no harmonized international consensus definitions of kidney failure and key surrogates of progression to kidney failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ecbac2a0f27c539402b549d8f4ac63
https://research.rug.nl/en/publications/5984117f-7546-4144-a885-57da66d2520c
https://research.rug.nl/en/publications/5984117f-7546-4144-a885-57da66d2520c
Publikováno v:
Journal of Hypertension
To treat hypertension, combining two or more antihypertensive drugs from different classes is often necessary. β-Blockers and renin-angiotensin-aldosterone system inhibitors, when combined, have been deemed 'less effective' based on partially overla
Autor:
Majid Kerolous, Stephan Ortiz, Chun Lin Chen, Harold M. Wright, Parviz Ghahramani, Daksha Desai-Krieger
Publikováno v:
American Journal of Therapeutics
Combining different classes of antihypertensives is more effective for reducing blood pressure (BP) than increasing the dose of monotherapies. The aims of this phase I study were to investigate pharmacokinetic and pharmacodynamic interactions between
Autor:
Pedro Cuevas, José M. La Fuente, Javier C. Angulo, Harold M. Wright, Juan Ignacio Martínez-Salamanca, Argentina Fernández, José Cardoso
Publikováno v:
The Journal of Sexual Medicine. 11:1182-1192
Introduction The efficacy of oral pharmacotherapy for erectile dysfunction (ED) (i.e., type 5 phosphodiesterase [PDE5] inhibitors) is significantly reduced in diabetic patients. Nebivolol is a selective β 1 ‐blocker used for treating hypertension
Autor:
D. Bennett Grinsfelder, David J. Lefer, Lili A. Barouch, Sandeep Patel, Marah E. Condit, Madhav Lavu, Saurabh Jha, Harold M. Wright, Shashi Bhushan, Juan Pablo Aragon, Susheel Gundewar, Benjamin L. Predmore, John W. Calvert
Publikováno v:
Journal of the American College of Cardiology. 58:2683-2691
This paper examined whether nebivolol protects the heart via nitric oxide (NO) synthase and NO-dependent signaling in an in vivo model of acute myocardial infarction.Beta(3)-adrenergic receptor (AR) activation promotes endothelial nitric oxide syntha
Autor:
Javier C. Angulo, Sandeep Gupta, José M. La Fuente, Iñigo Saenz De Tejada, Harold M. Wright, Pedro Cuevas, Argentina Fernández, Rocío González-Corrochano, Begoña Cuevas
Publikováno v:
The Journal of Sexual Medicine. 7:2681-2697
Introduction Traditional beta-blockers have sometimes been associated with erectile dysfunction (ED). Nebivolol is a cardioselective β 1 -adrenoceptor antagonist that promotes vasodilation through a nitric oxide (NO)-dependent mechanism. Aim We eval
Publikováno v:
Circulation. 130
Introduction: Combining different classes of antihypertensive drugs is more effective for achieving blood pressure (BP) control than increasing the dose of monotherapies. An aim of this study was to investigate pharmacodynamic (PD) interactions betwe
Autor:
Pasha Sarraf, Wendy M. Smith, Jennifer B. Kum, Charis Eng, Lauri A. Aaltonen, Bruce M. Spiegelman, Albert de la Chapelle, Elisabetta Mueller, Harold M. Wright
Publikováno v:
Molecular Cell. 3:799-804
The gamma isoform of the peroxisome proliferator-activated receptor, PPAR gamma, regulates adipocyte differentiation and has recently been shown to be expressed in neoplasia of the colon and other tissues. We have found four somatic PPAR gamma mutati
Publikováno v:
Proceedings of the National Academy of Sciences. 95:4333-4337
Adipose differentiation is an important part of the energy homeostasis system of higher organisms. Recent data have suggested that this process is controlled by an interplay of transcription factors including PPARgamma, the C/EBPs, and ADD1/SREBP1. A