Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Harold L. Schwartz"'
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:2299-2303
Previous studies have shown that, in patients with primary alterations in thyroid hormone secretion, the level of the natural logarithm of serum TSH (lnTSH) is negatively related to the level of free T4. Because such patients can generally be assumed
Autor:
Grant W. Anderson, Charles R. Sandhofer, Harold L. Schwartz, Daniel R. Oas, Cary N. Mariash, Jack H. Oppenheimer, Ruby J. Larson
Publikováno v:
Journal of Biological Chemistry. 273:16391-16399
The cerebellar Purkinje cell-specific PCP-2 gene is transcriptionally activated by thyroid hormone during the 2nd and 3rd weeks of postnatal life in the rat. In contrast, thyroid hormone has no detectable effects on PCP-2 expression in the fetal rat.
Autor:
Harold L. Schwartz, Jack H. Oppenheimer, Charles R. Sandhofer, Cary N. Mariash, Douglas Forrest
Publikováno v:
Molecular and Cellular Endocrinology. 137:109-115
In rat pups, thyroid hormone dependent brain development coincides with the appearance of the thyroid hormone receptor (TR)beta1 isoform. This finding led to the suggestion that TRbeta1 plays an essential role in brain development. The recent availab
Publikováno v:
Endocrine Reviews. 18:462-475
I. Introduction II. Developmental Schedules A. Species specificity B. Developmental studies in the rat III. Thyroid Hormone Action A. Sources of T4 and T3 B. The role of maternal thyroid hormone in fetal brain development: direct or indirect? C. Intr
Publikováno v:
Endocrinology. 138:3119-3124
Studies were undertaken to test whether alterations in fetal brain thyroid hormone levels during the final week of gestation can prematurely induce gene expression in brain or affect cerebellar morphogenesis. Pregnant dams were treated either by admi
Publikováno v:
Endocrinology. 137:911-917
Immunohistochemical studies previously reported from this laboratory showed that astrocytes in adult rat brain appear devoid of all thyroid hormone receptor (TR) isoforms. These findings, however, contrast with reports of measurable nuclear T3 bindin
Publikováno v:
Endocrinology. 135:1831-1836
The three currently recognized T3 binding thyroid hormone receptor (TR) isoforms, TR alpha 1, TR beta 1, and TR beta 2, arise from two distinct genes (alpha and beta), whereas two closely related non-T3-binding receptor variants, collectively designa
Publikováno v:
Journal of Biological Chemistry. 269:24777-24782
Messenger RNA for thyroid hormone receptor (TR) isoforms alpha 1 and beta 1 are widely distributed in rat tissues. Until recently, TR beta 2 mRNA was believed to be limited to the pituitary and the assumption was made that TR beta 2 protein was simil
Publikováno v:
Clinics in Laboratory Medicine. 13:543-561
This article reviews the major action that thyroid hormone exerts at the nuclear level by regulating the level of mRNAs of specific genes. There are at least three thyroid hormone receptor isoforms that mediate hormonal effects at the tissue level. R
Autor:
Thomas J. Berrodin, Ronald M. Lechan, Kelly D. Davis, Yanping Qi, Kevin A. Strait, Mitchell A. Lazar, Harold L. Schwartz, Jack H. Oppenheimer
Publikováno v:
Endocrinology. 132:2461-2469
The thyroid hormone receptors (TR) are nuclear proteins that include TR alpha and TR beta subtypes, each encoded by a separate gene. Both TR alpha and TR beta give rise to several isoforms of which three, TR alpha 1, TR beta 1, and TR beta 2 bind T3