Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Harold L. James"'
Publikováno v:
Thrombosis Research. 106:71-79
The activation of factor X (fX) to factor Xa (fXa) marks the penultimate step in the coagulation cascade and modulating fXa activity may be effective for antithrombotic therapy. Even though fXa inhibitors are screened using in vitro inhibition of hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21da03a4a89aaf25b9954a9342169780
https://doi.org/10.1016/s0049-3848(02)00076-2
https://doi.org/10.1016/s0049-3848(02)00076-2
Publikováno v:
Thrombosis and Haemostasis. 78:1049-1054
SummaryMouse factor X was highly purified from plasma using barium ion precipitation and chromatography on anion-exchange and heparin- agarose affinity chromatography columns. Intact and reduced patterns of mouse factor X in SDS-PAGE were similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1df28ab4181d5cc95f9657aaf0233bd
https://doi.org/10.1055/s-0038-1657685
https://doi.org/10.1055/s-0038-1657685
Publikováno v:
Thrombosis and Haemostasis. 75:313-317
SummaryNaturally occurring plasma factor XFriuli (pFXFr) is marginally activated by both the extrinsic and intrinsic coagulation pathways and has impaired catalytic potential. These studies were initiated to obtain confirmation that this molecule is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cfd060b166c9fb53840132965f3e88d
https://doi.org/10.1055/s-0038-1650267
https://doi.org/10.1055/s-0038-1650267
Publikováno v:
Thrombosis Research. 80:363-366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d3db4b22e5f2c2db78582eee765cf1
https://doi.org/10.1016/0049-3848(95)00188-w
https://doi.org/10.1016/0049-3848(95)00188-w
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1271(2-3):327-334
Variant factor X in an individual with a mild bleeding tendency was suspected based on deficient procoagulant activity (10–20% of normal) and antigen (30–35% of normal) levels of plasma factor X. Heteroduplex analysis of factor X gene exons indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7510da588fee58c90a5dd3e8ce20eea
Autor:
Deog Joong Kim, Harold L James
Publikováno v:
Biotechnology Letters. 16:549-554
Human embryonic kidney cells (293) were transfected with a construct containing human factor X cDNA and selected for G418 resistance. The level of expression of recombinant factor X in serum-free medium was 4 to 5 μg/ml. Purified recombinant factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b6d203f7b5803bf10fbc74ee8467ef
https://doi.org/10.1007/bf00128598
https://doi.org/10.1007/bf00128598
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1172:301-305
This study addresses whether a mutation in the factor VIIPadua gene could explain the reduced activity of the inherited variant protein. All nine exons of the normal and Padua factor VII gene were amplified using the polymerase chain reaction, cloned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781ab87d737addb6dff457bebe9525e5
https://doi.org/10.1016/0167-4781(93)90217-2
https://doi.org/10.1016/0167-4781(93)90217-2
Autor:
Harold L. James, Karleen S. Callahan, Joe G.N. Garcia, Sarah Iriana, David E. Griffith, David Holiday
Publikováno v:
Chest. 101:392-397
The pathogenesis of oxygen toxicity remains unknown but may involve leukocyte mediated injury. The effects of hyperoxia on several lower respiratory tract parameters were examined in bronchoalveolar lavage fluid of normal nonsmoking subjects who inha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44c4ce63b6a6ffff62f82e3c12d060a5
https://doi.org/10.1378/chest.101.2.392
https://doi.org/10.1378/chest.101.2.392
Publikováno v:
Blood. 77:317-323
ACTOR X IS A SERINE protease zymogen that plays F a pivotal role in blood coagulation.’ It can be activated physiologically by the extrinsic (factor VIIa/tissue factor complex) and intrinsic (factor IXa/factor VIIIa complex) pathways in the presenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34541628eb8037faa9cdf8e060f1f78
https://doi.org/10.1182/blood.v77.2.317.317
https://doi.org/10.1182/blood.v77.2.317.317
Publikováno v:
Human Genetics. 95
To seek the possible molecular defect in a patient with deficient factor X plasma procoagulant activity, factor X gene exosn and splice junctions were subjected to heteroduplex analyses and sequencing. A mutation in exon 2 was confirmed as substituti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eff8ddfd1b6d2a11c1de17daacc4e09
https://doi.org/10.1007/bf00209404
https://doi.org/10.1007/bf00209404