Výsledky vyhledávání - "Harold L. Howes"

Pyrantel tartrate, a new anthelmintic effective against infections of domestic animals

Autor: John C. Danilewicz, W. Courtney, William C Austin, James W. McFarland, J. E. Lynch, Lloyd H Conover, R. L. Cornwell, V. J. Theodorides, Harold L. Howes, D. H. Morgan

Publikováno v: Nature. 212(5067)

THIS communication reports the discovery of a new series of highly active anthelmintic compounds which exhibit a broad spectrum of activity against both adult and immature worm infections of domestic animals. One of them, pyrantel tartrate (Fig. 1, V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0290011e03450c1482ec89083220ddd
https://pubmed.ncbi.nlm.nih.gov/21105312

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Anticoccidial derivatives of 6-azauracil. 1. Enhancement of activity by benzylation of nitrogen-1. Observations on the design of nucleotide analogs in chemotherapy

Autor: Max W Miller, Harold L. Howes, Richard C. Koch, J. E. Lynch, Banavara L. Mylari, Sanford K. Figdor

Publikováno v: Journal of Medicinal Chemistry. 20:475-483

Benzylation of 6-azauracil at N-1 (which corresponds to the point of attachment of the ribose phosphate unit in pyrimidine nucleotides) has been found to augment its anticoccidial activity fourfold. The high potency of 1-benzyl-6-azauracil is ascribe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9327bebfd0e6fdd2c5493c7a2762a419
https://doi.org/10.1021/jm00214a003

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Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains

Autor: Shyam K. Gupta, J. E. Lynch, Larry R. Chappel, Sanford K. Figdor, Richard C. Koch, Banavara L. Mylari, Martin J. Lynch, Harold L. Howes, Max W Miller

Publikováno v: Journal of Medicinal Chemistry. 24:1337-1342

We report further progress in exploiting our earlier discovery that the anticoccidial activity of 6-azauracil increases markedly when appropriately substituted benzyl or phenyl groups are attached at N-1. With guidance from previous structure-activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd462e9bc37d1a051c253354c3830837
https://doi.org/10.1021/jm00143a015

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Anticoccidial derivatives of 6-azauracil. 5. Potentiation by benzophenone side chains

Autor: Shyam K. Gupta, Jay J. Rash, Martin J. Lynch, J. E. Lynch, Harold L. Howes, Max W Miller, Richard C. Koch, Larry R. Chappel, Ronnie D. Carroll, Banavara L. Mylari

Publikováno v: Journal of Medicinal Chemistry. 26:96-100

Attachment of p-benzophenone side chains at N1 was found to be one of the most effective modifications for enhancing the potency of 6-azauracil against a broad spectrum of coccidia in chickens. Compound 20 was about 1000-fold more potent than 6-azaur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61477db9a71e7b8800eb361845ac240c
https://doi.org/10.1021/jm00355a019

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Anticoccidial derivatives of 6-azauracil. 2. High potency and long plasma life of N1-phenyl structures

Autor: Banavara L. Mylari, Richard C. Koch, Martin J. Lynch, Harold L. Howes, Max W Miller, J. E. Lynch

Publikováno v: Journal of Medicinal Chemistry. 22:1483-1487

Attachment of substituted phenyl side chains at N1 of 6-azauracil caused striking increases in plasma life and anticoccidial potency. The increases were related in part to the acidity of the imide hydrogen. Maximum effects were shown by phenyl rings

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd9f32a8a64e01409caf65a22ea81e0
https://doi.org/10.1021/jm00198a010

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Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents

Autor: Banavara L. Mylari, Martin J. Lynch, Max W Miller, Sanford K. Figdor, J. E. Lynch, Harold L. Howes, Richard C. Koch

Publikováno v: Journal of medicinal chemistry. 23(10)

A series of 1-phenyl-6-azauracils containing sulfonamide substituents was prepared. In contrast to previous 1-phenyl-6-azauracils, some of these sulfonamides combine high activity against Eimeria tenella infections in chickens with a very rapid rate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df20885552c5599bd3781c13009add8
https://pubmed.ncbi.nlm.nih.gov/6893468

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