Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Harold L, Atwood"'
Autor:
Harold L. Atwood
Publikováno v:
Journal of Neurogenetics. 35:107-109
Marla Sokolowski's scientific achievements established her as an internationally recognized leader in behavioural genetics. As a graduate student, she made a significant discovery while observing natural populations of the fruit fly, Drosophila melan
Autor:
Leo Marin, Oressia Zalucki, Shanker Karunanithi, Nickolas A. Lavidis, Deniz Ertekin, Bruno van Swinderen, Harold L. Atwood, Drew Cylinder
Publikováno v:
eNeuro
Visual Abstract
Propofol is the most common general anesthetic used for surgery in humans, yet its complete mechanism of action remains elusive. In addition to potentiating inhibitory synapses in the brain, propofol also impairs excitatory neuro
Propofol is the most common general anesthetic used for surgery in humans, yet its complete mechanism of action remains elusive. In addition to potentiating inhibitory synapses in the brain, propofol also impairs excitatory neuro
Autor:
N. Akhtar-Danesh, K. M. Vandamme, Balaji G. Iyengar, C. Jennifer Chou, X. Zhao, Markus K. Klose, Harold L. Atwood, A. R. Campos
Publikováno v:
Genes, Brain and Behavior. 10:883-900
Genetic manipulation of individual neurons provides a powerful approach toward understanding their contribution to stereotypic behaviors. We describe and evaluate a method for identifying candidate interneurons and associated neuropile compartments t
Publikováno v:
European Journal of Neuroscience. 26:2428-2443
Frequenin (Frq) and its mammalian homologue, neuronal calcium sensor 1 (NCS-1), are important calcium-binding proteins which enhance neurotransmitter release and facilitation. Here, we report the discovery of a second Frq-encoding gene (frq2 )i nDros
Autor:
Scott J. Neal, Anthony K.-C. So, J. Timothy Westwood, Robert M. Tanguay, Harold L. Atwood, Shanker Karunanithi, Adrienne Best
Publikováno v:
Physiological Genomics. 25:493-501
In Drosophila larvae, acquired synaptic thermotolerance after heat shock has previously been shown to correlate with the induction of heat shock proteins (Hsps) including HSP70. We tested the hypothesis that synaptic thermotolerance would be signific
Publikováno v:
Journal of Neurobiology. 66:273-280
cAMP analogs and activation of adenylyl cyclase by forskolin strongly potentiate synaptic transmission at the Drosophila neuromuscular junction. These effects are generally attributed to activation of cAMP-dependent protein kinase. Recent reports on
Publikováno v:
The Journal of Comparative Neurology. 499:583-602
Elucidating how neuronal networks process information requires identification of critical individual neurons and their connectivity patterns. For this purpose, we used the third-instar Drosophila larval brain and applied reverse-genetic tools, immuno
Autor:
Yong-Qi Lin, Konrad E. Zinsmaier, Shanker Karunanithi, Leo Marin, Jinhui Zhang, Jane Anne Horne, Harold L. Atwood, Ian A. Meinertzhagen, Ken Dawson-Scully, Mays Imad
Publikováno v:
Synapse. 61:1-16
The synaptic vesicle-associated cysteine string protein (CSP) is critical for neurotransmitter release at the neuromuscular junction (NMJ) of Drosophila, where the approximately 4% of mutant flies lacking CSP that survive to adulthood exhibit spastic
Autor:
Gregory T. Macleod, Hong Bao, Harold L. Atwood, Bing Zhang, Richard W. Daniels, Milton P. Charlton
Publikováno v:
Journal of Neurophysiology. 94:1888-1903
AP180 plays an important role in clathrin-mediated endocytosis of synaptic vesicles (SVs) and has also been implicated in retrieving SV proteins. In Drosophila, deletion of its homologue, Like-AP180 (LAP), has been shown to increase the size of SVs b
Autor:
Sarvari Panchumarthi, Miriam Schoenfield, Milton P. Charlton, Harold L. Atwood, Leo Marin, Andrea Wellington, Fangle Hu, Xiufang Guo, Konrad E. Zinsmaier, Greg T. Macleod
Publikováno v:
Neuron. 47(3):379-393
SummaryWe have identified EMS-induced mutations in Drosophila Miro (dMiro), an atypical mitochondrial GTPase that is orthologous to human Miro (hMiro). Mutant dmiro animals exhibit defects in locomotion and die prematurely. Mitochondria in dmiro muta