Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Harold I. Saavedra"'
Autor:
Alexandra N. Aquino-Acevedo, Joel A. Orengo-Orengo, Melanie E. Cruz-Robles, Harold I. Saavedra
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract This review aims to outline mitotic kinase inhibitors’ roles as potential therapeutic targets and assess their suitability as a stand-alone clinical therapy or in combination with standard treatments for advanced-stage solid tumors, includ
Externí odkaz:
https://doaj.org/article/c0344e92c24549a4a58a5e3eb44a159c
Autor:
Shirley Jusino, Yainyrette Rivera-Rivera, Camille Chardón-Colón, Patricia C. Rodríguez-Rodríguez, Janeishly Román-González, Valeria S. Juliá-Hernández, Angel Isidro, Qianxing Mo, Harold I. Saavedra
Publikováno v:
Cell Division, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background Triple-negative breast cancer (TBNC) is an aggressive breast cancer subtype with a poor prognosis. Shugoshin-1 (SGO1) protects chromatids from early separation. Previous studies from our group have demonstrated that transient SGO1
Externí odkaz:
https://doaj.org/article/a3fd9f91da8f45a9944d91c1d16c0a87
Autor:
Yainyrette Rivera-Rivera, Geraldine Vargas, Neha Jaiswal, Angel Núñez-Marrero, Jiannong Li, Dung-Tsa Chen, Steven Eschrich, Marilin Rosa, Joseph O. Johnson, Julie Dutil, Srikumar P. Chellappan, Harold I. Saavedra
Publikováno v:
Cell Division, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Molecular epidemiology evidence indicates racial and ethnic differences in the aggressiveness and survival of breast cancer. Hispanics/Latinas (H/Ls) and non-Hispanic Black women (NHB) are at higher risk of breast cancer (BC)-related death r
Externí odkaz:
https://doaj.org/article/bc3caee0596a4f7ca187e7de2ddb60a7
Autor:
Yainyrette Rivera-Rivera, Mihaela Marina, Shirley Jusino, Miyoung Lee, Jaleisha Vélez Velázquez, Camille Chardón-Colón, Geraldine Vargas, Jaya Padmanabhan, Srikumar P. Chellappan, Harold I. Saavedra
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to centrosomes and kinetochores, controlling centrosome separation, chromosome attachments to kinetochores, and the spindle assembly checkpoint. These process
Externí odkaz:
https://doaj.org/article/349186be6236452795f3845aa7cf9050
E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer
Autor:
Shirley Jusino, Camille Chardón-Colón, Armando J Ruiz-Justiz, Margarita Bonilla-Claudio, Angel A. Isidro, Melanie E Cruz-Robles, Harold I. Saavedra, Guillermo N. Armaiz-Pena, Jaleisha Vélez-Velázquez, Yainyrette Rivera-Rivera
Publikováno v:
Exp Biol Med (Maywood)
E2F3 is a transcription factor that may initiate tumorigenesis if overexpressed. Previously, we demonstrated that E2F3 mRNA is overexpressed in breast cancer and that E2F3 overexpression results in centrosome amplification and unregulated mitosis, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29c03254a8ac07b9907c3ab52a17da4
https://doi.org/10.1177/15353702211035693
https://doi.org/10.1177/15353702211035693
Autor:
Shirley Jusino, Harold I. Saavedra
Publikováno v:
Experimental Biology and Medicine. 244:1419-1429
The epithelial-to-mesenchymal transition (EMT) is a complex cellular process in which epithelial cells acquire mesenchymal properties. EMT occurs in three biological settings: development, wound healing and fibrosis, and tumor progression. Despite oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed17c5bbef2f0d8a51144a2de4bd233c
https://doi.org/10.1177/1535370219881360
https://doi.org/10.1177/1535370219881360
Publikováno v:
Exp Biol Med (Maywood)
Biological therapies against breast cancer patients with tumors positive for the estrogen and progesterone hormone receptors and Her2 amplification have greatly improved their survival. However, to date, there are no effective biological therapies ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f37b969e992f555bf66f62c3d2986b
https://europepmc.org/articles/PMC8113731/
https://europepmc.org/articles/PMC8113731/
Autor:
Harold I. Saavedra, Philipp Kaldis, Hiroaki Kiyokawa, Mary K. Harrison, Xiangbin Zeng, Arsene M. Adon, Stacy Sannem
Publikováno v:
Molecular and cellular biology. 40(23)
The two mitotic centrosomes direct spindle bipolarity to maintain euploidy. Centrosome amplification—the acquisition of ≥3 centrosomes—generates multipolar mitoses, aneuploidy, and chromosome instability to promote cancer biogenesis. While much
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293ad366cc9e2815910c6de1adaad0c6
https://pubmed.ncbi.nlm.nih.gov/19933848
https://pubmed.ncbi.nlm.nih.gov/19933848
Autor:
Jaleisha Vélez Velázquez, Shirley Jusino, Jaya Padmanabhan, Srikumar Chellappan, Mihaela Marina, Miyoung Lee, Yainyrette Rivera-Rivera, Camille Chardón-Colón, Harold I. Saavedra, Geraldine Vargas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to centrosomes and kinetochores, controlling centrosome separation, chromosome attachments to kinetochores, and the spindle assembly checkpoint. These processes preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d2978e933d961c0c2bd8d4a8ba302c
https://pubmed.ncbi.nlm.nih.gov/33907253
https://pubmed.ncbi.nlm.nih.gov/33907253
Publikováno v:
Oncotarget
// Miyoung Lee 1 , Yainyrette Rivera-Rivera 3 , Carlos S. Moreno 2 and Harold I. Saavedra 3 1 Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA 2 Department of Patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e908762f00d570bcc4e6084130d92df
https://doi.org/10.18632/oncotarget.20765
https://doi.org/10.18632/oncotarget.20765