Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Harold H. Wolf"'
Autor:
James P. Stables, H. Steve White, Michael R. Franklin, Markus Schmutz, Harvey J. Kupferberg, Harold H. Wolf
Publikováno v:
Epilepsia. 49:1213-1220
Summary Purpose: To evaluate the anticonvulsant profile and behavioral toxicity of rufinamide in animal seizure models compared to the established antiepileptic drugs (AEDs): phenytoin, phenobarbital, valproate, and ethosuximide, or vehicle. Methods:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b54c02d76a3d0cadeb6b030126b8e42
https://doi.org/10.1111/j.1528-1167.2008.01552.x
https://doi.org/10.1111/j.1528-1167.2008.01552.x
Autor:
Harold H. Wolf, Gregory S. Shen, R. Tyler McCabe, Huiling Lian, Jose H. Woodhead, Solomon S. Steiner, Christopher A. Rhodes, H. Steve White, R. Duane Sofia
Publikováno v:
Journal of Pharmaceutical Sciences. 89:867-875
Felbamate (FBM) is a novel antiepileptic drug (AED) and neuroprotectant (NP) compound that interacts with strychnine‐insensitive (SI) glycine receptors in brain (IC 50 = 374 μM). FBM concentrations required to interact with SI glycine receptors ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58e9544d246aaa252c6e7c51a23b78b
https://doi.org/10.1002/1520-6017(200007)89:7<867::aid-jps3>3.0.co
https://doi.org/10.1002/1520-6017(200007)89:7<867::aid-jps3>3.0.co
Publikováno v:
Epilepsia. 41:17-20
Summary: Purpose: These studies further investigate the ability of topiramate (TPM) to enhance γ-aminobutyric acid (GABA)-mediated inhibition through a benzodiazepine-insensitive pathway. Methods: Topiramate (30 and 100 μM) enhancement of GABA (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3efa9662892f093ed6900eb6b8a0ee15
https://doi.org/10.1111/j.1528-1157.2000.tb02165.x
https://doi.org/10.1111/j.1528-1157.2000.tb02165.x
Publikováno v:
Epilepsy Research. 28:167-179
The anticonvulsant topiramate is effective in laboratory animals against maximal electroshock seizures, amygdala kindling, and spike-wave discharges and has demonstrated efficacy in humans for the treatment of complex partial seizures. However, its m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6079d705b508c5da3f15d0537d06cc
https://doi.org/10.1016/s0920-1211(97)00045-4
https://doi.org/10.1016/s0920-1211(97)00045-4
Autor:
H. Steve White, Tober Christine, Harold H. Wolf, Rostock Angelika, Reni Bartsch, Chris Rundfeldt, Jürgen Engel, Klaus Unverferth
Publikováno v:
Epilepsy Research. 28:17-28
The anticonvulsant activity of the novel drug AWD 140-190 (4-(p-bromophenyl)-3-morpholino-1H-pyrrole-2-carboxylic acid methyl ester) was evaluated in animal models of epileptic seizures. AWD 140-190 was active at nontoxic doses after oral and intrape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae12a14cf425dbdd52357ae3c5bee15
https://doi.org/10.1016/s0920-1211(97)00023-5
https://doi.org/10.1016/s0920-1211(97)00023-5
Publikováno v:
The Italian Journal of Neurological Sciences. 16:73-77
A number of widely different animal seizure models have been employed in the search for new and novel anticonvulsant drugs useful for the treatment of human epilepsy. At present, no single laboratory test will, in itself, establish the presence or ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79d1bdc1acabbc2e9d3adae1134160c
https://doi.org/10.1007/bf02229077
https://doi.org/10.1007/bf02229077
Autor:
Timothy E Albertson, Schwe Fang Pong, Eugene G. Drust, Steve H. White, Gwen A. Skeen, Harold H. Wolf, L. G. Stark, Ewart A. Swinyard
Publikováno v:
Epilepsy Research. 15:35-45
The anticonvulsant properties of F-721(3-diethylamino-2,2-dimethylpropyl 5[p-trifluoromethylphenyl]-2furoate hydrochloride) were investigated in a battery of in vivo and in vitro anticonvulsant model systems. After intraperitoneal (ip) administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635eada05d5223e295362e831780b8b1
https://doi.org/10.1016/0920-1211(93)90007-t
https://doi.org/10.1016/0920-1211(93)90007-t
Autor:
Harold H. Wolf
Publikováno v:
Encyclopedia of Clinical Pharmacy ISBN: 0824706080
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9404561994a4080ac4430a97ecd4d5d
https://doi.org/10.3109/9780824706081.039
https://doi.org/10.3109/9780824706081.039
Autor:
Dagmar Hönack, Bernhard Kutscher, Rostock Angelika, Jürgen Engel, Harold H. Wolf, Wolfgang Löscher, H. Steve White, Tober Christine, Emanuele E. Polymeropoulos, Chris Rundfeldt, Reni Bartsch
Publikováno v:
Epilepsy research. 23(3)
The anticonvulsant activity of the novel drug D-23129 ( N -(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester) was evaluated in animal models of epileptic seizures. D-23129 was active after oral and intraperitoneal administration in rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e57fdbf2a71ccdc765ba9cca982d018
https://pubmed.ncbi.nlm.nih.gov/8739124
https://pubmed.ncbi.nlm.nih.gov/8739124
Publikováno v:
Epilepsy research. 20(1)
Felbamate (2-phenyl-1,3-propanediol dicarbamate) is a novel anticonvulsant substance whose mechanism of action is not clearly understood. The present investigation examined its ability to modulate the strychnine-insensitive glycine receptor associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08595cf7958a60790892486bffd51ce
https://pubmed.ncbi.nlm.nih.gov/7713059
https://pubmed.ncbi.nlm.nih.gov/7713059