Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Harold F. Hardman"'
Publikováno v:
General Pharmacology: The Vascular System. 12:199-204
1. 1. Two dihydropyridine calcium antagonists, nifedipine and FR 7534, produced a slow complete relaxation of potassium depolarized (40 mM) large coronary arteries obtained from dogs, cows and pigs. These effects were only partially reversed by incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73887b4f5b3a09a8e9ab8009f21bb08
https://doi.org/10.1016/0306-3623(81)90012-4
https://doi.org/10.1016/0306-3623(81)90012-4
Publikováno v:
Journal of Molecular and Cellular Cardiology. 10:249-261
The effects of adenosine on myocardial metabolism and oxygen consumption were examined in the isolated supported dog heart preparation (ISHP) perfused at a constant coronary blood flow. Heart rate was controlled by right atrial pacing. Coronary arter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ddfba15af806a967011edd51fb668b
https://doi.org/10.1016/0022-2828(78)90347-4
https://doi.org/10.1016/0022-2828(78)90347-4
Publikováno v:
Journal of Cardiovascular Pharmacology. 7:977-982
The purpose of this study was to compare the effects of nicorandil [SG-75; 2-nicotinamidoethyl nitrate (ester)] and nitroglycerin on the distribution of blood flow between subendocardium and subepicardium [endocardial/epicardial blood flow ration (en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c448dc0c75dc24663f2ba19ef4e3fe4
https://doi.org/10.1097/00005344-198509000-00026
https://doi.org/10.1097/00005344-198509000-00026
Publikováno v:
Basic Research in Cardiology. 74:494-508
Regional myocardial perfusion (assessed by 15 mu tracer microspheres) was determined at various levels of stenosis of the left circumflex coronary artery in anesthetized dogs. Measurements during control and at three levels of stenosis produced by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddce7fdb95841a681bedae70ad79530
https://doi.org/10.1007/bf01907643
https://doi.org/10.1007/bf01907643
Publikováno v:
The American Journal of Cardiology. 48:269-279
The effects of dopamine, dobutamine and isoproterenol on coronary hemodynamics, severity of stenosis, distal bed resistance and transmural myocardial perfusion gradients with radioactive microspheres were studied in dogs with a mild obstruction of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4824aa3ae9e9946b484e522ae9a2d89
https://doi.org/10.1016/0002-9149(81)90607-x
https://doi.org/10.1016/0002-9149(81)90607-x
Publikováno v:
European Journal of Pharmacology. 67:101-104
The direct effects of adenosine on cardiac oxygen balance, hemodynamics and regional myocardial perfusion were studied in isolated canine hearts. Intracoronary infusion of adenosine produced a dose-dependent shift in the transmural distribution of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf33f6afd651b2d5bc15769b7f951613
https://doi.org/10.1016/0014-2999(80)90014-x
https://doi.org/10.1016/0014-2999(80)90014-x
Publikováno v:
The American Journal of Cardiology. 63:J11-J17
The effect of the new antianginal drug, nicorandil, was studied in several models of myocardial ischemia in anesthetized dogs. In animals subjected to an acute or chronic coronary artery occlusion, nicorandil produced increases in collateral perfusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd1e831a5806a60ade1936e71bc454e
https://doi.org/10.1016/0002-9149(89)90199-9
https://doi.org/10.1016/0002-9149(89)90199-9
Publikováno v:
Life Sciences. 29:673-680
Δ 9 -Tetrahydrocannabinol (THC), the primary psychoactive component of marihuana produces pronounced effects on the cardiovascular system including bradycardia and hypotension. A decrease in sympathetic activity may contribute to these actions. In c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50710242f24a20de213323d29aa96c5b
https://doi.org/10.1016/0024-3205(81)90019-9
https://doi.org/10.1016/0024-3205(81)90019-9
Publikováno v:
European Journal of Pharmacology. 110:271-276
The positive inotropic effect of AP-A was studied in anesthetized dogs with a severe stenosis of the left anterior descending coronary artery. Peak positive dP/dt (mm Hg/s) and % segment shortening (%SS) were used as indices of contractile function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e9208d2df3ed0629c01e3e35a73499
https://doi.org/10.1016/0014-2999(85)90223-7
https://doi.org/10.1016/0014-2999(85)90223-7
Publikováno v:
British Journal of Pharmacology. 57:409-412
1 A 3 min intracoronary infusion of adenosine (50 mug/min) produced a significant decrease in coronary artery perfusion pressure, left ventricular systolic pressure and myocardial O2 consumption in the isolated supported heart preparation of the dog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2402ec0b76b77a8fa9657f9944a3701
https://doi.org/10.1111/j.1476-5381.1976.tb07681.x
https://doi.org/10.1111/j.1476-5381.1976.tb07681.x