Výsledky vyhledávání - "Harold F Coombs"

Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology

Autor: Son Yong Karst, Timothy C. Cox, Suhaib Borgeia, Roderick T. Bronson, Mohamed G. Hassan, Laura G. Reinholdt, Harold F Coombs, Stephen A. Murray, Michelle Curtain, David E. Bergstrom, Louise A Dionne, Heather Fairfield, Leah Rae Donahue, Kristina Palmer

Publikováno v: Developmental Biology. 415:216-227

Craniofacial abnormalities are among the most common features of human genetic syndromes and disorders. The etiology of these conditions is often complex, influenced by both genetic context and the environment. Frequently, craniofacial abnormalities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b01d2b9aeee8744661a9514c807537f
https://doi.org/10.1016/j.ydbio.2015.07.023

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Synthetic Peptide CK2.3 Enhances Bone Mineral Density in Senile Mice

Autor: Anja Nohe, Lora M Schell, John Nguyen, Saurabh Dharmadhikari, Randall L. Duncan, Liyun Wang, Linda Sequeira, Hilary Weidner, Ryan Kabrick, Harold F Coombs

Publikováno v: Journal of bone research

Background: Osteoporosis is a silent disease caused by low bone mineral density that results in bone fractures in 1 out of 2 women and 1 in 4 men over the age of 50. Although several treatments for osteopenia and osteoporosis are available, they have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e66ad6ffb0fa623a0e5438b70749914
https://doi.org/10.4172/2572-4916.1000190

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Systemic Injection of CK2.3, a Novel Peptide Acting Downstream of Bone Morphogenetic Protein Receptor BMPRIa, Leads to Increased Trabecular Bone Mass

Autor: Harold F Coombs, Beth Bragdon, Kristine E. Olli, Chris Bowen, Jeremy Bonor, Hemanth Akkiraju, Anja Nohe, Randall L. Duncan, Leah Rae Donahue

Publikováno v: Journal of Orthopaedic Research. 33:208-215

Bone Morphogenetic Protein 2 (BMP2) regulates bone integrity by driving both osteogenesis and osteoclastogenesis. However, BMP2 as a therapeutic has significant drawbacks. We have designed a novel peptide CK2.3 that blocks the interaction of Casein K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7052b05d799345ced32d335f655fd1c
https://doi.org/10.1002/jor.22752

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Multiple quantitative trait loci for cortical and trabecular bone regulation map to mid-distal mouse chromosome 4 that shares linkage homology to human chromosome 1p36

Autor: Lindsay G. Horton, Leah Rae Donahue, Wesley G. Beamer, Kathryn L. Shultz, Clifford J. Rosen, Harold F Coombs

Publikováno v: Journal of Bone and Mineral Research. 27:47-57

The mid-distal region of mouse chromosome 4 (Chr 4) is homologous with human Chr 1p36. Previously, we reported that mouse Chr 4 carries a quantitative trait locus (QTL) with strong regulatory effect on volumetric bone mineral density (vBMD). The inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0b1707a9d88de6ea1b6b924217fb2a
https://doi.org/10.1002/jbmr.515

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BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat

Autor: Wesley G. Beamer, Laura G. Reinholdt, Ernesto Canalis, Kathryn L. Shultz, Clifford J. Rosen, Victoria E. DeMambro, Leah Rae Donahue, Harold F Coombs, Cheryl L. Ackert-Bicknell

Publikováno v: Journal of Bone and Mineral Research

The distal end of mouse chromosome 1 (Chr 1) harbors quantitative trait loci (QTLs) that regulate bone mineral density (BMD) and share conserved synteny with human chromosome 1q. The objective of this article was to map this mouse distal Chr 1 region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7373e6f63585558b34f7c978a859a24
https://doi.org/10.1002/jbmr.200

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Gender- and Compartment-Specific Bone Loss in C57BL/6J Mice: Correlation to Season?

Autor: Harold F Coombs, Clifford J. Rosen, Krista M. Delahunty, K. L. Svenson, Michael F. Holick, Lindsay G. Horton, Wesley G. Beamer, K. L. Shultz, Michael A. Marion

Publikováno v: Journal of Clinical Densitometry. 12:89-94

Seasonal variation in bone mineral density (BMD) has been documented in humans, and has been attributed to changes in 25-hydroxyvitamin D [25(OH)D] synthesis. To test the hypothesis that seasonal changes in bone mass occur in laboratory mice, we meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f121e2e6f8ccd67531d3a0e0d922ecab
https://doi.org/10.1016/j.jocd.2008.10.008

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Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes

Autor: Lindsay G. Horton, Ernesto Canalis, Krista M. Delahunty, Kathryn L. Shultz, Leah Rae Donahue, Wesley G. Beamer, Cheryl L. Ackert-Bicknell, Harold F Coombs, Clifford J. Rosen

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 22(8)

Genetic analyses with mouse congenic strains for distal Chr1 have identified three closely linked QTLs regulating femoral vBMD, mid-diaphyseal cortical thickness, and trabecular microstructure in a sex-dependent fashion. The homologous relationship b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a460c8b68195fdfe299e636800bc48c4
https://pubmed.ncbi.nlm.nih.gov/17451375

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