Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Harold E. Layton"'
Autor:
Anita T Layton, Harold E Layton
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 2, p e1006108 (2019)
We have developed the first computational model of solute and water transport from Bowman space to the papillary tip of the nephron of a human kidney. The nephron is represented as a tubule lined by a layer of epithelial cells, with apical and basola
Externí odkaz:
https://doaj.org/article/b8bcbd6b228d48fd8132d82eced5bb49
The goal of this study is to investigate the functional implications of the sexual dimorphism in transporter patterns along the proximal tubule. To do so, we have developed sex-specific computational models of solute and water transport in the proxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c2dd014345ef232adfba46a0b5024d
https://europepmc.org/articles/PMC6172582/
https://europepmc.org/articles/PMC6172582/
Publikováno v:
Clinical Journal of the American Society of Nephrology. 9:1781-1789
The ability of mammals to produce urine hyperosmotic to plasma requires the generation of a gradient of increasing osmolality along the medulla from the corticomedullary junction to the papilla tip. Countercurrent multiplication apparently establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92b02f36742686442bc7ab383051eaa
https://doi.org/10.2215/cjn.08750812
https://doi.org/10.2215/cjn.08750812
Publikováno v:
American Journal of Physiology-Renal Physiology. 304:F653-F664
The thick ascending limb (TAL) is a major NaCl reabsorbing site in the nephron. Efficient reabsorption along that segment is thought to be a consequence of the establishment of a strong transepithelial potential that drives paracellular Na+uptake. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd67e0a2ce4f878109b7f290ace3f7c0
https://doi.org/10.1152/ajprenal.00101.2012
https://doi.org/10.1152/ajprenal.00101.2012
Publikováno v:
Mathematical Biosciences. 230:115-127
The tubuloglomerular feedback (TGF) system in the kidney, a key regulator of glomerular filtration rate, has been shown in physiologic experiments in rats to mediate oscillations in thick ascending limb (TAL) tubular fluid pressure, flow, and NaCl co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d3ab0abcd55758d80426596c8f18c6
https://doi.org/10.1016/j.mbs.2011.02.004
https://doi.org/10.1016/j.mbs.2011.02.004
Publikováno v:
Acta Physiologica. 202:361-378
The urine concentrating mechanism in the mammalian renal inner medulla (IM) is not understood, although it is generally considered to involve countercurrent flows in tubules and blood vessels. A possible role for the three-dimensional relationships o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adef1f956631a9e2e6844a31b919448a
https://doi.org/10.1111/j.1748-1716.2010.02214.x
https://doi.org/10.1111/j.1748-1716.2010.02214.x
Publikováno v:
American Journal of Physiology-Renal Physiology. 298:F973-F987
A new, region-based mathematical model of the urine concentrating mechanism of the rat renal inner medulla (IM) was used to investigate the significance of transport and structural properties revealed in recent studies that employed immunohistochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8c15aa58b80624350d141e2ad799f0
https://doi.org/10.1152/ajprenal.00249.2009
https://doi.org/10.1152/ajprenal.00249.2009
Publikováno v:
Bulletin of Mathematical Biology. 72:314-339
In a mathematical model of the urine concentrating mechanism of the inner medulla of the rat kidney, a nonlinear optimization technique was used to estimate parameter sets that maximize the urine-to-plasma osmolality ratio (U/P) while maintaining the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9745d7fe5a610b2e4408c2942f62ec7b
https://doi.org/10.1007/s11538-009-9448-0
https://doi.org/10.1007/s11538-009-9448-0
Publikováno v:
Physiology. 24:250-256
The urine concentrating mechanism of the mammalian kidney, which can produce a urine that is substantially more concentrated than blood plasma during periods of water deprivation, is one of the enduring mysteries in traditional physiology. Owing to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa76b20742e6b8a9e655ff62b0c0402
https://doi.org/10.1152/physiol.00013.2009
https://doi.org/10.1152/physiol.00013.2009
Autor:
Jeff M. Sands, Harold E. Layton
Publikováno v:
Seminars in Nephrology. 29:178-195
The renal medulla produces concentrated urine through the generation of an osmotic gradient extending from the cortico-medullary boundary to the inner medullary tip. This gradient is generated in the outer medulla by the countercurrent multiplication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958afa0da785b0e3d687fc52f928bb38
https://doi.org/10.1016/j.semnephrol.2009.03.008
https://doi.org/10.1016/j.semnephrol.2009.03.008