Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Harold C. Smith"'
Autor:
Ryan P. Bennett, Elena N. Postnikova, Brett P. Eaton, Yingyun Cai, Shuiqing Yu, Charles O. Smith, Janie Liang, Huanying Zhou, Gregory A. Kocher, Michael J. Murphy, Harold C. Smith, Jens H. Kuhn
Publikováno v:
JCI Insight, Vol 7, Iss 1 (2022)
Sangivamycin is a nucleoside analog that is well tolerated by humans and broadly active against phylogenetically distinct viruses, including arenaviruses, filoviruses, and orthopoxviruses. Here, we show that sangivamycin is a potent antiviral against
Externí odkaz:
https://doaj.org/article/b37aa9b5a1a447c7b6e4a792bd43f84d
Autor:
Ryan P. Bennett, Courtney L. Finch, Elena N. Postnikova, Ryan A. Stewart, Yingyun Cai, Shuiqing Yu, Janie Liang, Julie Dyall, Jason D. Salter, Harold C. Smith, Jens H. Kuhn
Publikováno v:
Viruses, Vol 13, Iss 1, p 52 (2020)
Filoviruses, such as Ebola virus and Marburg virus, are of significant human health concern. From 2013 to 2016, Ebola virus caused 11,323 fatalities in Western Africa. Since 2018, two Ebola virus disease outbreaks in the Democratic Republic of the Co
Externí odkaz:
https://doaj.org/article/5945a79a982544e080a424c8503cb249
Publikováno v:
BioTechniques, Vol 34, Iss 3, Pp 524-530 (2003)
Recombinant mammalian proteins expressed in E. coli can be difficult to purify in high yield in a soluble and functional form. Various techniques have been described to prevent proteolysis of expressed proteins and/or their sequestering as insoluble
Externí odkaz:
https://doaj.org/article/af2beff7cf0c407d931e6b2aad30528c
Autor:
Jens H. Kuhn, Shuiqing Yu, Elena Postnikova, Ryan P. Bennett, Huanying Zhou, Charles O. Smith, Harold C. Smith, Michael J Murphy, Yíngyún Caì, Janie Liang, Brett P Eaton, Gregory Kocher
Publikováno v:
JCI Insight
Sangivamycin is a nucleoside analog that is well-tolerated by humans and broadly active against phylogenetically distinct viruses, including arenaviruses, filoviruses, and orthopoxviruses. Here, we show that sangivamycin is a potent antiviral against
Autor:
Claire Devine, Karen I. Lange, Zeljka Smit-McBride, Sharon L. Oltjen, Andy Golden, Harold C. Smith, Sofia Tsiropoulou, Oliver E. Blacque, Joanne A Matsubara, Natalie Acker, Andrew Gordus, Bruce E. Vogel
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly. Canonical disease models suggest that defective interactions between complement factor H (CFH) and cell surface heparan sulfate (HS) result in increased alterna
Publikováno v:
Cell Biology of Trauma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccd104817ae621dfce335528c612c026
https://doi.org/10.1201/9781003067801-18
https://doi.org/10.1201/9781003067801-18
Publikováno v:
Sub-cellular biochemistry. 93
The DNA mutagenic enzyme known as APOBEC3G (A3G) plays a critical role in innate immunity to Human Immunodeficiency Virus-1 (HIV-1 ). A3G is a zinc-dependent enzyme that mutates select deoxycytidines (dC) to deoxyuridine (dU) through deamination with
Publikováno v:
Trends Mol Med
The infectivity of the human immunodeficiency virus (HIV) depends on overcoming APOBEC3 (A3) innate immunity and does so predominantly through the expression of the viral protein, Vif, which induces A3 degradation in the proteasome. Disruption of the
Autor:
Harold C. Smith, Abhijith Saseendran, Joseph E. Wedekind, Ryan P. Bennett, Rudi Fasan, Rachel B. Bonn, Sai Shashank Chavali, Sachitanand M. Mali
Publikováno v:
J Biol Chem
RNA represents a potential target for new antiviral therapies, which are urgently needed to address public health threats such as the human immunodeficiency virus (HIV). We showed previously that the interaction between the viral Tat protein and the
Autor:
Alan E. Friedman, Ryan P. Bennett, Ryan A. Stewart, Rebecca Joseph, Bogdan Polevoda, Thareendra De Zoysa, Rebecca Greiner, Harold C. Smith
Publikováno v:
Journal of Biological Chemistry. 292:8642-8656
APOBEC3G (A3G) belongs to the AID/APOBEC protein family of cytidine deaminases (CDA) that bind to nucleic acids. A3G mutates the HIV genome by deamination of dC to dU, leading to accumulation of virus-inactivating mutations. Binding to cellular RNAs