Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Harold B. Hartman"'
Autor:
Jidong Cai, Sathapana Kongsamut, Lei Tang, Lisa L. Kerman, Joachim E. Roehr, Anthony Sandrasagra, Paul Weissensee, Harold B. Hartman
Publikováno v:
European Journal of Pharmacology. 317:417-423
Iloperidone (HP 873; 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone) is a compound currently in clinical trials for the treatment of schizophrenia. Iloperidone displays affinity for dopamine D 2 receptors
Autor:
Sam Kongsamut, Deborah E. Bregna, Lisa L. Kerman, Joachim E. Roehr, ‡ and Ann T. Woods-Kettelberger, Mark R. Szewczak, Harold B. Hartman, Jurcak John G, Roy Corbett, Hrib Nicholas J, Kendra L. Burgher, Sharon H. Kafka
Publikováno v:
Journal of Medicinal Chemistry. 39:4044-4057
HP-236 (3-[4-[4-(6-Fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate; P-9236) (54) displayed a pharmacological profile indicative of potential atypical antipsychotic activity. A series of piperazinyl butyl thiaz
Autor:
Edward J. Glamkowski, Roy Corbett, Paul G. Conway, Yulin Chiang, Bordeau Kenneth J, Harold B. Hartman, Joseph T. Strupczewski, Mark R. Szewczak, Helsley Grover C, Carole A. Wilmot
Publikováno v:
Journal of Medicinal Chemistry. 38:1119-1131
A series of 3-[[(aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles was synthesized and evaluated as potential antipsychotic D2/5-HT2 antagonists. Most of these compounds showed potent antipsychotic-like activity in an apomorphine-induced climbing mouse p
Autor:
Paul G. Conway, Joachim E. Roehr, Kendra L. Burgher, Jurcak John G, L. L. Kerman, Harold B. Hartman, Hrib Nicholas J, Woods Ann Theresa
Publikováno v:
Journal of Medicinal Chemistry. 37:2308-2314
A series of benzisoxaazole- and benzisothiazole-3-carboxamides has been prepared and tested for potential antipsychotic activity. In general, the compounds showed an affinity for dopamine D 2 and serotonin 5HT 2A and 5HT 1A receptors. Several members
Autor:
Paul G. Conway, Joachim E. Roehr, Hrib Nicholas J, L. L. Kerman, Kendra L. Burgher, Jurcak John G, Woods Ann Theresa, Harold B. Hartman
Publikováno v:
ChemInform. 25
A series of benzisoxaazole- and benzisothiazole-3-carboxamides has been prepared and tested for potential antipsychotic activity. In general, the compounds showed an affinity for dopamine D 2 and serotonin 5HT 2A and 5HT 1A receptors. Several members
Publikováno v:
Physiologybehavior. 65(3)
Alterations of monoamine metabolites in CSF and behavioral abnormalities were studied in rats with neonatal hippocampal lesions and controls. Lesions of the ventral hippocampus were produced bilaterally by ibotenic acid on postnatal day 7. Lesion-ind
Autor:
Harold B. Hartman, Joachim E. Roehr, Raymond W. Kosley, Wayne W. Petko, Bernard L. Kotyuk, Paul G. Conway, Robert J. Cherill
Publikováno v:
Drug Development Research. 12:197-209
Various studies suggest that the 7-dihydroxypropionyl derivative of forskolin, HP 663, effectively lowers intraocular pressure (IOP) by a novel mechanism. Biochemically, HP 663 stimulates rat striatal adenylate cyclase and displays an affinity for fo