Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Harold B. Brooks"'
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), and regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22628225105d10e01b1823421dc49781
https://doi.org/10.1158/1535-7163.c.6536578.v1
https://doi.org/10.1158/1535-7163.c.6536578.v1
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
PDF file - 43K, Effect of LY2228820 on MK2 phosphorylation in mouse peripheral blood mononuclear cells (PBMC) and from patients with multiple myeloma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22324d5e3fb3ac4e9a4d4c1e89f1bae3
https://doi.org/10.1158/1535-7163.22500817.v1
https://doi.org/10.1158/1535-7163.22500817.v1
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
PDF file - 86K, Supplemental Table 1. Kinases where LY2228820 shows >1000-fold selectivity in vitro (p38 MAPK vs. other kinase).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32264138e74601170f5f533f626867e
https://doi.org/10.1158/1535-7163.22500811.v1
https://doi.org/10.1158/1535-7163.22500811.v1
Autor:
Xiang S. Ye, Yong Wang, Juan A. Velasco, Courtney Tate, James J. Starling, Louis F. Stancato, Chuan Shih, Susan E. Pratt, Stephen H. Parsons, Songqing Na, Denis McCann, Mary Mader, Enrique Jambrina, Jeremy R. Graff, Raymond Gilmour, Alfonso De Dios, Edward M. Chan, Harold B. Brooks, Nathan A. Brooks, Bryan D. Anderson, Robert M. Campbell
PDF file - 90K, shRNA silencing of p38a MAPK in U-87MG glioma (Westerns and xenograft tumor growth data).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d956222196f28eb3db5494e81e7cc02
https://doi.org/10.1158/1535-7163.22500814.v1
https://doi.org/10.1158/1535-7163.22500814.v1
Autor:
Harold B. Brooks, Shuang Luo, Timothy I. Meier, Kwame Frimpong, Timothy B. Durham, Matthew Lee, Kevin Robert Fales, Kenneth Jeff Thrasher, Philip W. Iversen, Robert T. Foreman, Yu-Hua Hui, Charles D. Spencer, Sandaruwan Geeganage, Kenneth D. Roth, Alicia Torrado, Yong Wang, Chong Si, Jefferson R. Mc Cowan, Stefan Jon Thibodeaux, Zhipei Wu, Timothy Alan Shepherd, James Lee Toth, Tao Wang, Yue-Wei Qian, Robert Dean Dally, Njoroge F George, Susan A. Konicek
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
AICARFT is a folate dependent catalytic site within the ATIC gene, part of the purine biosynthetic pathway, a pathway frequently upregulated in cancers. LSN3213128 is a potent (16 nM) anti-folate inhibitor of AICARFT and selective relative to TS, SHM
Autor:
Anke Klippel, Rui Wang, Loredana Puca, Andrew Lee Faber, Weihua Shen, Shripad V. Bhagwat, Kannan Karukurichi, Feiyu Fred Zhang, Carmen Perez, Ramon Rama, Ana Ramos, Yi Zheng, Zahid Bonday, James Thomas, Harold B. Brooks, Lisa J. Kindler, Sarah M. Bogner, Parisa Zolfaghari, Mark Hicks II, Sophie Callies, Brian Mattioni, Laurie LeBrun, Jim Durbin, Erin Anderson, Chris Mayne, Edward Kesicki, Gabrielle Kolakowski, Steven W. Andrews, Barbara J. Brandhuber
Publikováno v:
Molecular Cancer Therapeutics. 20:P142-P142
Phosphoinositide 3-kinase alpha (PI3Kα) H1047R mutations are activating oncogenic events that occur in ~15% of advanced breast cancers. While there is one PI3Kα inhibitor FDA-approved for patients with PI3Kα-mutated breast cancer, and many others
Autor:
Alicia Torrado, Shane Atwell, Timothy B. Durham, Njoroge F George, Timothy I. Meier, Brandon J. Margolis, Stefan Jon Thibodeaux, Yu-Hua Hui, Robert Dean Dally, Kevin Robert Fales, Kenneth Jeff Thrasher, James Lee Toth, Jing Wang, Kwame Frimpong, Susan A. Konicek, Yong Wang, Chong Si, Kenneth D. Roth, Matthew Lee, Zhipei Wu, Jefferson R. Mc Cowan, Timothy Alan Shepherd, Sandaruwan Geeganage, Harold B. Brooks
Publikováno v:
Journal of Medicinal Chemistry. 60:9599-9616
A hallmark of cancer is unbridled proliferation that can result in increased demand for de novo synthesis of purine and pyrimidine bases required for DNA and RNA biosynthesis. These synthetic pathways are frequently upregulated in cancer and involve
Autor:
Courtney M. Tate, Enrique Jambrina, Harold B. Brooks, Raymond Gilmour, Yong Wang, Jeremy R. Graff, Bryan D. Anderson, Stephen Parsons, Juan A. Velasco, Susan E. Pratt, Edward M. Chan, Songqing Na, Mary M. Mader, James J. Starling, Nathan A. Brooks, Robert M. Campbell, Alfonso De Dios, Louis Stancato, Xiang S. Ye, Denis J. McCann, Chuan Shih
Publikováno v:
Molecular Cancer Therapeutics. 13:364-374
p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in response to environmental factors, oncogenic stress, radiation, and chemotherapy. p38α MAPK phosphorylates a number of substrates, including MAPKAP-K2 (MK2), and regulates
Autor:
Maria J. Barrero, Jacinto Sarmentero, Manuel Serrano, Harold B. Brooks, Osvaldo Graña, David G. Pisano, Robert M. Campbell, Verónica García-Carpizo, Bomie Han, Sergio Ruiz-Llorente
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports
Instituto de Salud Carlos III (ISCIII)
Scientific Reports
The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well understood. Here, we describe that NSD2 contributes to the proliferation of a subset of lung c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbda4f43193376984c873f6f90057a32
http://hdl.handle.net/20.500.12105/8572
http://hdl.handle.net/20.500.12105/8572
Autor:
Daniel H. Robertson, Boyu Zhong, Scott A. Watkins, Jose S. Mendoza, Harold B. Brooks, Charles D. Spencer, Elizabeth Collins, C. Jaramillo, José Eugenio de Diego, Bryan D. Anderson, Faming Zhang, Chafiq Hamdouchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1943-1947
Structure-based design approach was successfully used to guide the evolution of imidazopyridine scaffold yielding new structural class of highly selective inhibitors of cyclin dependent kinases that were able to form a new interaction with an identif