Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Harold A. Chapman"'
Autor:
David H. Peng, Bertha Leticia Rodriguez, Lixia Diao, Limo Chen, Jing Wang, Lauren A. Byers, Ying Wei, Harold A. Chapman, Mitsuo Yamauchi, Carmen Behrens, Gabriela Raso, Luisa Maren Solis Soto, Edwin Roger Parra Cuentes, Ignacio I. Wistuba, Jonathan M. Kurie, Don L. Gibbons
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream s
Externí odkaz:
https://doaj.org/article/219973ddbc6547bdba9bd0531b756cc7
Autor:
Maximilian Strunz, Lukas M. Simon, Meshal Ansari, Jaymin J. Kathiriya, Ilias Angelidis, Christoph H. Mayr, George Tsidiridis, Marius Lange, Laura F. Mattner, Min Yee, Paulina Ogar, Arunima Sengupta, Igor Kukhtevich, Robert Schneider, Zhongming Zhao, Carola Voss, Tobias Stoeger, Jens H. L. Neumann, Anne Hilgendorff, Jürgen Behr, Michael O’Reilly, Mareike Lehmann, Gerald Burgstaller, Melanie Königshoff, Harold A. Chapman, Fabian J. Theis, Herbert B. Schiller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell sta
Externí odkaz:
https://doaj.org/article/c56bf52cb142499c98ef8cc384553dbe
Autor:
Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J.A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, Jonathan M. Kurie
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109009- (2021)
Summary: Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneit
Externí odkaz:
https://doaj.org/article/2c651979e55c43638647e4def6c85ef2
Autor:
Donald M. McDonald, Dana T. Aftab, James G. Christensen, Harold A. Chapman, Weon-Kyoo You, Sebastien P. Tabruyn, Vikash Bhagwandin, Casey W. Williamson, Ryan M. Naylor, Ying Wei, Toshina Ishiguro-Oonuma, Barbara Sennino
PDF file - 2MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37233c8899853a83224e3321196dd35d
https://doi.org/10.1158/2159-8290.22532993.v1
https://doi.org/10.1158/2159-8290.22532993.v1
Autor:
Rachel Ettinger, David V. Serreze, Torrian Green, Zoë Bichler, Timothy J. Hines, Jeremy J. Racine, Brynn M Cairns, Laura C. Anderson, Abigail L. D. Tadenev, Rosalinda Doty, Jacqueline K. White, Robert W. Burgess, Janine M Wotton, Harold D. Chapman, Meaghan E Dyer
Publikováno v:
The Journal of Immunology. 205:2026-2038
It has become increasingly appreciated that autoimmune responses against neuronal components play an important role in type 1 diabetes (T1D) pathogenesis. In fact, a large proportion of islet-infiltrating B lymphocytes in the NOD mouse model of T1D p
Autor:
Jaymin J. Kathiriya, Chaoqun Wang, Minqi Zhou, Alexis Brumwell, Monica Cassandras, Claude Jourdan Le Saux, Max Cohen, Kostantinos-Dionysios Alysandratos, Bruce Wang, Paul Wolters, Michael Matthay, Darrell N. Kotton, Harold A. Chapman, Tien Peng
Publikováno v:
Nature cell biology, vol 24, iss 1
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we demonstrate that human alveolar type 2 cells (hAEC2s), unlike murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a23d5ce0833a4e930fbaf6763f481b
https://escholarship.org/uc/item/2qh206wf
https://escholarship.org/uc/item/2qh206wf
Autor:
Harold A. Chapman
Publikováno v:
The Journal of clinical investigation, vol 131, iss 19
J Clin Invest
J Clin Invest
Epithelial cells are charged with protection at barrier sites, but whether this normally beneficial response might sometimes become dysfunctional still needs definition. Here, we recognized a pattern of imbalance marked by basal epithelial cell growt
Autor:
Alexis Brumwell, Harold A. Chapman, Vincent C. Auyeung, Feroz R. Papa, Maike Thamsen, Michael S. Downey, Dean Sheppard, Bradley J. Backes, Jaymin J. Kathiriya, Talia A. Wenger
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive interstitial fibrosis, which leads to severe debilitation, respiratory failure, and death. In IPF, environmental exposures interact with genetic risk factors to engender critical patho-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aad9c1f7f0f13d4146f65458325184f8
https://doi.org/10.1101/2021.09.16.460705
https://doi.org/10.1101/2021.09.16.460705
Autor:
Jennifer R. Dwyer, Jeremy J. Racine, Harold D. Chapman, Anna Quinlan, Maximiliano Presa, Grace A. Stafford, Ingo Schmitz, David V. Serreze
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(2)
Type 1 diabetes (T1D) in both humans and NOD mice is caused by T cell–mediated autoimmune destruction of pancreatic β cells. Increased frequency or activity of autoreactive T cells and failures of regulatory T cells (Tregs) to control these pathog
Autor:
Angela L. Linderholm, Justin M. Oldham, Genevieve Montas, Claude Jourdan Le Saux, Nancy K. Hills, Scott M. Turner, Kirk D. Jones, Paul J. Wolters, Prerna Kotak, Jeffrey A. Golden, B. Trinh, Darren Leong, Ying Wei, Martin Decaris, Harold A. Chapman, Jin-Woo Song, Elena Foster
Publikováno v:
N Engl J Med
EGCG and Pulmonary Fibrosis Nine patients who were scheduled to undergo lung biopsy for pulmonary fibrosis were given epigallocatechin gallate (EGCG) for 2 weeks. Levels of fibrotic markers in lung...