Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Harold A Spurgeon"'
Autor:
Oliver Monfredi, Larissa A Maltseva, Harold A Spurgeon, Mark R Boyett, Edward G Lakatta, Victor A Maltsev
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67247 (2013)
UNLABELLED:Spontaneous, submembrane local Ca(2+) releases (LCRs) generated by the sarcoplasmic reticulum in sinoatrial nodal cells, the cells of the primary cardiac pacemaker, activate inward Na(+)/Ca(2+)-exchange current to accelerate the diastolic
Externí odkaz:
https://doaj.org/article/ff061e47c6704d36906c88d7c89b15c6
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57079 (2013)
Ca(2+)-activated basal adenylate cyclase (AC) in rabbit sinoatrial node cells (SANC) guarantees, via basal cAMP/PKA-calmodulin/CaMKII-dependent protein phosphorylation, the occurrence of rhythmic, sarcoplasmic-reticulum generated, sub-membrane Ca(2+)
Externí odkaz:
https://doaj.org/article/83f283c5142440bbba387d25be563df8
Autor:
Yael Yaniv, Harold A Spurgeon, Alexey E Lyashkov, Dongmei Yang, Bruce D Ziman, Victor A Maltsev, Edward G Lakatta
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37582 (2012)
Mitochondria dynamically buffer cytosolic Ca(2+) in cardiac ventricular cells and this affects the Ca(2+) load of the sarcoplasmic reticulum (SR). In sinoatrial-node cells (SANC) the SR generates periodic local, subsarcolemmal Ca(2+) releases (LCRs)
Externí odkaz:
https://doaj.org/article/10ea9a5e79704baa86e55da61b95554f
Autor:
Yue Li, Syevda Sirenko, Harold A. Spurgeon, Dongmei Yang, Tatiana M. Vinogradova, Edward G. Lakatta, Daniel R. Riordon
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 311:H532-H544
Spontaneous beating of the heart pacemaker, the sinoatrial node, is generated by sinoatrial node cells (SANC) due to gradual change of the membrane potential called diastolic depolarization (DD). Spontaneous, submembrane local Ca2+ releases (LCR) fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffaa3b66c83a3c51bfa927c832ccda59
https://doi.org/10.1152/ajpheart.00765.2015
https://doi.org/10.1152/ajpheart.00765.2015
Autor:
Edward G. Lakatta, Harold A. Spurgeon, Victor A. Maltsev, Daniel Yaeger, Syevda Sirenko, Tatiana M. Vinogradova, Rostislav Bychkov, Yael Yaniv
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 311:H251-H267
Coupling of an intracellular Ca2+ clock to surface membrane ion channels, i.e., a “membrane clock, ” via coupling of electrochemical Na+ and Ca2+ gradients ( ENa and ECa, respectively) has been theorized to regulate sinoatrial nodal cell (SANC) n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee9dcb107ec91927405c8aa1d4a707d
https://doi.org/10.1152/ajpheart.00667.2015
https://doi.org/10.1152/ajpheart.00667.2015
Autor:
Edward G. Lakatta, Bruce D. Ziman, Yael Yaniv, Harold A. Spurgeon, Syevda Sirenko, Victor A. Maltsev
Publikováno v:
Journal of Molecular and Cellular Cardiology. 62:80-89
Beneficial clinical bradycardic effects of ivabradine (IVA) have been interpreted solely on the basis of If inhibition, because IVA specifically inhibits If in sinoatrial nodal pacemaker cells (SANC). However, it has been recently hypothesized that S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500fd63be539f7ba7cba78514fe4d572
https://doi.org/10.1016/j.yjmcc.2013.04.026
https://doi.org/10.1016/j.yjmcc.2013.04.026
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H1428-H1438
The spontaneous action potential (AP) firing rate of sinoatrial node cells (SANCs) involves high-throughput signaling via Ca2+-calmodulin activated adenylyl cyclases (AC), cAMP-mediated protein kinase A (PKA), and Ca2+/calmodulin-dependent protein ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d176cbeacbc6dfa046cabc25b352a47
https://doi.org/10.1152/ajpheart.00969.2012
https://doi.org/10.1152/ajpheart.00969.2012
Publikováno v:
Molecules (Basel, Switzerland)
Molecules; Volume 17; Issue 7; Pages: 8241-8254
Molecules; Volume 17; Issue 7; Pages: 8241-8254
Recent clinical trials have shown that ivabradine (IVA), a drug that inhibits the funny current (I(f)) in isolated sinoatrial nodal cells (SANC), decreases heart rate and reduces morbidity and mortality in patients with cardiovascular diseases. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f63cd3d0162413e06c7f6e0d8c3afa3
https://doi.org/10.3390/molecules17078241
https://doi.org/10.3390/molecules17078241
Publikováno v:
Molecules, Vol 17, Iss 7, Pp 8241-8254 (2012)
Recent clinical trials have shown that ivabradine (IVA), a drug that inhibits the funny current (If) in isolated sinoatrial nodal cells (SANC), decreases heart rate and reduces morbidity and mortality in patients with cardiovascular diseases. While I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::3e148626898b5f8481637f7fb481263d
http://www.mdpi.com/1420-3049/17/7/8241
http://www.mdpi.com/1420-3049/17/7/8241
Autor:
Harold A. Spurgeon, Ariel L. Escobar, Victor A. Maltsev, Michael D. Stern, Bruce D. Ziman, Edward G. Lakatta, Yael Yaniv
Publikováno v:
Journal of Molecular and Cellular Cardiology. 51:902-905
Whether intracellular Ca(2+) regulates sinoatrial node cell (SANC) action potential (AP) firing rate on a beat-to-beat basis is controversial. To directly test the hypothesis of beat-to-beat intracellular Ca(2+) regulation of the rate and rhythm of S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ca04b7212f58956471c65df9c9be29
https://doi.org/10.1016/j.yjmcc.2011.08.029
https://doi.org/10.1016/j.yjmcc.2011.08.029